estimation of placenta function using t 2 measurements during hyper and normoxia
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Mother w/o mask. Mother + O 2 mask. Estimation of placenta function using T 2* measurements during hyper- and normoxia. 0 . 10 . 2 0 . 30 . 40 . 50 . 6 0 . 70 . 8 0 . 90 . 100 . 4142. May 9 th , 12 am, Computer no 73. David Alberg Peters

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estimation of placenta function using t 2 measurements during hyper and normoxia

Mother w/o mask

Mother + O2 mask

Estimation of placenta function using T2*measurements during hyper- and normoxia

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4142

May 9th, 12 am, Computer no 73

estimation of placenta function using t 2 measurements during hyper and normoxia1

David AlbergPeters

    • Department of Clinical Engineering, Central Denmark Region, Aarhus, Denmark
    • [email protected]
  • Anne Sørensen
    • Department of Obstetrics and Gynecology, Aarhus University, Aalborg Hospital, Denmark
  • TorbenFründ
    • Department of Radiology, Aarhus University, Aalborg Hospital, Denmark
  • Ole BjarneChristiansen
      • Department of Obstetrics and Gynecology, Aarhus University, Aalborg Hospital, Denmark
  • NielsUldbjerg
    • Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark.

Estimation of placenta function using T2*measurements during hyper- and normoxia

4142

May 9th, 12 am, Computer no 73

materials
Materials

6 x

g.w.

28-35

MATLAB

protocol
Protocol
  • Bold imaging (separate study)
  • Multi Echo GE
  • Multi Echo GE

Localizer

10 min

Normoxia (21% O2)

Hyperoxia (100% O2)

  • Multi Echo GE
    • TR=70.9ms, TE=3.02 to 67.5 ms – step 4.3 ms.
    • FOV 350x350 mm, Matrix 256 x 128, Three 8 mm slices
acquisition
Acquisition

Placenta ROI

Multi Echo GE sequence - Increasing TE

processing
Processing
  • T2* fitted (Levenberg Marquardt implemented in MATLAB)
    • Fitted either Pixel by pixel or in a region of interest (ROI)
results roi based fitting
Results (ROI based fitting)

Subject 1

Subject 2

Mean change (P<0.01)

Subject 3

Subject 4-5-6

results pixel by pixel fitting
Results (Pixel by pixel fitting)

Normoxic

Hyperoxic

T2* (ms)

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90

100

conclusion
Conclusion
  • T2* increases significantly in the placenta when the mother breathes oxygen
  • The change in T2*is inhomogeneously distributed in the placenta
  • The change in T2* is most likely caused by a change in the pO2 of the blood in placenta
placenta structure
Placenta structure

Fetal placenta

Maternal placenta

discussion
Discussion

Same?

Same?

Correspondance between “blue” areas in pre oxygen T2* map and fetal side of placenta?

discussion1
Discussion
  • Is the difference between hyperoxic and normoxic placenta T2* value an indicator of placenta function?
  • Is a reduced response sign of a poorly functioning placenta?
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