Estimation of placenta function using t 2 measurements during hyper and normoxia
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Mother w/o mask. Mother + O 2 mask. Estimation of placenta function using T 2* measurements during hyper- and normoxia. 0. 10. 2 0. 30. 40. 50. 6 0. 70. 8 0. 90. 100. 4142. May 9 th , 12 am, Computer no 73. David Alberg Peters

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Estimation of placenta function using T 2* measurements during hyper- and normoxia

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Estimation of placenta function using t 2 measurements during hyper and normoxia

Mother w/o mask

Mother + O2 mask

Estimation of placenta function using T2*measurements during hyper- and normoxia

0

10

20

30

40

50

60

70

80

90

100

4142

May 9th, 12 am, Computer no 73


Estimation of placenta function using t 2 measurements during hyper and normoxia1

  • David AlbergPeters

    • Department of Clinical Engineering, Central Denmark Region, Aarhus, Denmark

    • [email protected]

  • Anne Sørensen

    • Department of Obstetrics and Gynecology, Aarhus University, Aalborg Hospital, Denmark

  • TorbenFründ

    • Department of Radiology, Aarhus University, Aalborg Hospital, Denmark

  • Ole BjarneChristiansen

    • Department of Obstetrics and Gynecology, Aarhus University, Aalborg Hospital, Denmark

  • NielsUldbjerg

    • Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark.

  • Estimation of placenta function using T2*measurements during hyper- and normoxia

    4142

    May 9th, 12 am, Computer no 73


    Materials

    Materials

    6 x

    g.w.

    28-35

    MATLAB


    Protocol

    Protocol

    • Bold imaging (separate study)

    • Multi Echo GE

    • Multi Echo GE

    Localizer

    10 min

    Normoxia (21% O2)

    Hyperoxia (100% O2)

    • Multi Echo GE

      • TR=70.9ms, TE=3.02 to 67.5 ms – step 4.3 ms.

      • FOV 350x350 mm, Matrix 256 x 128, Three 8 mm slices


    Acquisition

    Acquisition

    Placenta ROI

    Multi Echo GE sequence - Increasing TE


    Processing

    Processing

    • T2* fitted (Levenberg Marquardt implemented in MATLAB)

      • Fitted either Pixel by pixel or in a region of interest (ROI)


    Results roi based fitting

    Results (ROI based fitting)

    Subject 1

    Subject 2

    Mean change (P<0.01)

    Subject 3

    Subject 4-5-6


    Results pixel by pixel fitting

    Results (Pixel by pixel fitting)

    Normoxic

    Hyperoxic

    T2* (ms)

    0

    10

    20

    30

    40

    50

    60

    70

    80

    90

    100


    Conclusion

    Conclusion

    • T2* increases significantly in the placenta when the mother breathes oxygen

    • The change in T2*is inhomogeneously distributed in the placenta

    • The change in T2* is most likely caused by a change in the pO2 of the blood in placenta


    Placenta structure

    Placenta structure

    Fetal placenta

    Maternal placenta


    Discussion

    Discussion

    Same?

    Same?

    Correspondance between “blue” areas in pre oxygen T2* map and fetal side of placenta?


    Discussion1

    Discussion

    • Is the difference between hyperoxic and normoxic placenta T2* value an indicator of placenta function?

    • Is a reduced response sign of a poorly functioning placenta?


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