Parental occupation in farming and childhood cancer risk in i4c
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Parental occupation in farming and childhood cancer risk in I4C. Ann Olsson & Joachim Schüz. Rational. Majority of case-control studies show an association Stronger associations with indoor pesticide exposure Internal inconsistencies, e.g. lack of dose-response

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Parental occupation in farming and childhood cancer risk in i4c

Parental occupation in farming andchildhood cancer risk in I4C

Ann Olsson & Joachim Schüz


Rational

  • Majority of case-control studies show an association

  • Stronger associations with indoor pesticide exposure

  • Internal inconsistencies, e.g. lack of dose-response

  • Few cohorts show no or weaker association

Case-control studies are prone to bias!


Information bias

Recall differences regarding maternaloccupational exposureto pesticides prior to conception

Years between the date of birth and the date of the interview

 cases  controls

[Schüz et al., Am J Epi, 2003]


Selection bias

Typical pattern:

Social gradient

among controls

[Law, Br J Cancer, 2002]


I4cfarm
I4Cfarm

  • Design: Pool prospective cohorts

  • Benefits:

    • Data collected prior to diagnosis

    • Data collected closer after occurrence

    • Increased power to study “rare events”


Farming around the world

Proportion of workersemployed in agriculture

Global pesticide production


I4cfarm objectives
I4Cfarm - objectives

  • Investigate if parental occupations in different types of farming is associated with increased risk of cancer in their offspring

  • Evaluate the risk of childhood cancer associated with self reported parental use of pesticides during pregnancy

    • Compare type and frequency reported in case-control studies

  • If possible assess whether the risk of childhood cancer associated with parental exposure to occupation as a farmer and pesticides vary by exposure time-windows (preconception, prenatal, and postnatal)


I4cfarm study team
I4Cfarm – study team

  • IARC (Ann Olsson, Joachim Schüz, Kurt Straif)

  • INSERM (Jacqueline Clavel)

  • MCRI (Gabriella Tikellis)

  • NCI (Martha Linet)

  • CREAL (Martine Vrijheid)

  • Eligible cohorts (PI’s)

    • MoBa, DNBC, ALSPAC, THIS, ?...



Next steps
Next steps

  • Eligibility of further cohorts?

  • Transfer of data to MCRI (Gabriella)

  • Harmonization of disease data (Martha) and occupational data (Ann & Martine)

  • Data analyses (at IARC)

  • Manuscripts (Study team)


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