1 / 37

Development of urogenital system

Development of urogenital system. 1. Development of kidney and ureter 2. Development of urinary bladder and urethra 3. Abnormality in urinary system 4. Development of gonad 5. Development of reproductive tracts 6. Abnormality in reproductive system. Urinary system,

matteo
Download Presentation

Development of urogenital system

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Development of urogenital system 1. Development of kidney and ureter 2. Development of urinary bladder and urethra 3. Abnormality in urinary system 4. Development of gonad 5. Development of reproductive tracts 6. Abnormality in reproductive system

  2. Urinary system, genital excurrent duts Mesoneohric ridge Gonadal ridge Gonad Intermediate mesoderm 3rd week Urogenital ridge Nephrogenic cord Intermediate mesoderm ───→ ─────→ Primordium of urogenital system ─── Intermediate mesoderm

  3. Head (segmentation)→ Nephrotome →Pronephros Other (migration, proliferation)→ Nephrogenic cord → Mesonephros and Metanephros Urogenital ridge

  4. Mesonephric ridge Gonadal ridge

  5. Mesonephric ridge Gonadal ridge

  6. Pronephric duct Pronephric tubule Degeneration in 1 week Mesonephric duct Development of kidney and ureter 1. Pronephros 4th week, no function Pronephric tubule Nephrotome (7-14th somite) Pronephric duct

  7. 2. Mesonephros 14-18th somite Time： end of 4th week Function: transient urinary Destiny: Most degeneration, Small part form male excurrent duct Mesonephric duct Mesonephric tubule

  8. Middle part of nephrogenic cord 80 transverse S-shaped tubule Mesonephric tubule Mesonephric duct Continus to pronephric duct Inner part form renal capsule Outer end bind to mesonephric duct End bind to colaca

  9. 3.Metanephros Source one: Ureteric bud Source two: Metanephrogenic blastema Time： begin at 5th week, exist forever Function： begin at 3th month, urinary function Position： rise gradually Mesonephric duct Mesonephric tubule Metanephros

  10. End of mesonephric duct (adjacent to colaca) Source one Ureteric bud Prolong Ureter Enbranchment＞12 Renal pelvis, renal calyce (The end branched as T) Collecting tube

  11. Source two Cap-shaped cell cluster S-shaped tubule Connect with collecting tubule Renal capsule Glomerulus Renal tubule Renal corpuscle Nephron ＋ Metanephrogenic blastema (Mesoderm of the mesonephric ridge) Metanephric tubule

  12. Collecting tubule Mesonephric tubule Metanephrogenic blastema Ureteric bud Renal pelvis Renal calyce

  13. From its original location (adjacent to the developing baldder) to its mature location (in the retroperitoneum just caudal to the diaphragm)

  14. Male Female Upper part Urinary bladder Urinary bladder Upper part of urethra Urogenital sinus Middle part Urethra 4-7th week Lower part Lower part of urethra Vestibula of vagina Ureorectal septum Anorectal canal Development of urinary bladder and urethra Colaca

  15. A B E D C

  16. Ureter Mesonephric duct

  17. Abnormality in urinary system 2. Horseshoe kidney 1. Polycystic kidney

  18. 3. Single kidney Right single kidney Left single kidney

  19. 5. Ectopic kidney 4. Double ureter

  20. 7. Exstrophy of bladder 6. Urachal fistula

  21. Development of gonad Gonad differentiation at 7th week Developmental stage： Sex undifferentiated stage → Sex differentiated stage Reproductive tracts：２ → 1 Proper current： → Feamle Testis determining factor, TDF TDF determine the differentiation to testis. The gene of TDF located at sex determining region of the Y (SRY).

  22. Endoderm cell of yolk sac Proliferation differentiation 3rd to 4th week Promordial germ cells Migration in 1 week 6th week 6th week Gonadal ridge Primitive sex cord Superfacail epithelium →cell cord • Development of • undifferentiated gonad

  23. Promordial germ cells Large and round endoderm cells in yolk sac

  24. Dorsal mesentary of the gut Migration of promordial germ cells

  25. Seperated from surface 7th week Seminiferous tubule Mesenchymal cells Cells of sex cord Promordial germ cells ＋ ＋ Spermatogonium Interstitial cells Sustantacular cells Testis 2. Development of testis Primary sex cord(TDF)

  26. Superfacial epithelium No TDF Primary sex cord After 8 weeks Secondary sex cord (Cortical cord） 16th week Degeneration Mesenchymal cells Primordial follicel Primordial germ cells Cells of sex cord Ooginum Stroma ＋ Follicular cells ＋ Ovary 3. Development of ovary

  27. Ovary Testis Rete testis Tubule rectus Follicle Seminiferous tubule Spermatogonium Primary oocyte Sustantacular cell Follicular cell Follicle Seminiferous tubule

  28. ４. Descend of testis and ovary

  29. Development of reproductive tracts 1. Undifferentiated stage

  30. 2. Differentiation of male reproductive tract Proximal part ── epididymal duct Distal part── ductus deferens and ejaculatory duct Mesonephric duct Most of ── degeneration Some of ── efferent ducts Mesonephric tubule Paramesonephric duct Regression ──

  31. 3. Differentiation of female reproductive tract Upper and middle segment：oviduct Lower segment: uterus Paramesonephric duct Vagina Sinus tubercle： Vaginal plate Mesonephric duct and tubule regression

  32. Abnormality of reproductive system 1. Cryptorchidism

  33. 2. Congenital inguinal hernia 3. Double uterus

  34. 4. Vaginal atresia 5. Hypospadias

  35. 6. Hermaphroditism

More Related