Development of urogenital system
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Development of urogenital system. 1. Development of kidney and ureter 2. Development of urinary bladder and urethra 3. Abnormality in urinary system 4. Development of gonad 5. Development of reproductive tracts 6. Abnormality in reproductive system. Urinary system,

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Development of urogenital system

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Development of urogenital system

Development of urogenital system

1. Development of kidney and ureter

2. Development of urinary bladder and

urethra

3. Abnormality in urinary system

4. Development of gonad

5. Development of reproductive tracts

6. Abnormality in reproductive system


Development of urogenital system

Urinary system,

genital excurrent duts

Mesoneohric ridge

Gonadal ridge

Gonad

Intermediate mesoderm

3rd week

Urogenital ridge

Nephrogenic cord

Intermediate mesoderm

───→

─────→

Primordium of urogenital system

───

Intermediate mesoderm


Development of urogenital system

Head (segmentation)→ Nephrotome →Pronephros

Other (migration, proliferation)→ Nephrogenic cord →

Mesonephros and Metanephros

Urogenital ridge


Development of urogenital system

Mesonephric ridge

Gonadal ridge


Development of urogenital system

Mesonephric ridge

Gonadal ridge


Development of urogenital system

Pronephric duct

Pronephric tubule

Degeneration in 1 week

Mesonephric duct

Development of kidney and ureter

1. Pronephros

4th week, no function

Pronephric

tubule

Nephrotome (7-14th somite)

Pronephric

duct


Development of urogenital system

2. Mesonephros

14-18th somite

Time:

end of 4th week

Function:

transient urinary

Destiny:

Most degeneration,

Small part form male

excurrent duct

Mesonephric duct

Mesonephric tubule


Development of urogenital system

Middle part of nephrogenic cord

80 transverse S-shaped tubule

Mesonephric tubule

Mesonephric duct

Continus to pronephric duct

Inner part form renal capsule

Outer end bind to mesonephric duct

End bind to colaca


Development of urogenital system

3.Metanephros

Source one:

Ureteric bud

Source two:

Metanephrogenic

blastema

Time:

begin at 5th week,

exist forever

Function:

begin at 3th month,

urinary function

Position:

rise gradually

Mesonephric duct

Mesonephric tubule

Metanephros


Development of urogenital system

End of mesonephric duct

(adjacent to colaca)

Source one

Ureteric bud

Prolong

Ureter

Enbranchment>12

Renal pelvis, renal calyce

(The end branched as T)

Collecting tube


Development of urogenital system

Source two

Cap-shaped cell cluster

S-shaped tubule

Connect with collecting tubule

Renal capsule

Glomerulus

Renal tubule

Renal corpuscle

Nephron

Metanephrogenic blastema

(Mesoderm of the mesonephric ridge)

Metanephric tubule


Development of urogenital system

Collecting tubule

Mesonephric tubule

Metanephrogenic blastema

Ureteric bud

Renal pelvis

Renal calyce


Development of urogenital system

From its original location (adjacent to the developing baldder) to its mature location (in the retroperitoneum just caudal to the diaphragm)


Development of urogenital system

Male

Female

Upper part

Urinary bladder

Urinary bladder

Upper part of urethra

Urogenital sinus

Middle part

Urethra

4-7th week

Lower part

Lower part of urethra

Vestibula of vagina

Ureorectal septum

Anorectal canal

Development of

urinary bladder and urethra

Colaca


Development of urogenital system

A

B

E

D

C


Development of urogenital system

Ureter

Mesonephric duct


Development of urogenital system

Abnormality in urinary system

2. Horseshoe kidney

1. Polycystic kidney


Development of urogenital system

3. Single kidney

Right single kidney

Left single kidney


Development of urogenital system

5. Ectopic kidney

4. Double ureter


Development of urogenital system

7. Exstrophy of bladder

6. Urachal fistula


Development of urogenital system

Development of gonad

Gonad differentiation at 7th week

Developmental stage:

Sex undifferentiated stage → Sex differentiated stage

Reproductive tracts:2 → 1

Proper current: → Feamle

Testis determining factor, TDF

TDF determine the differentiation to testis.

The gene of TDF located at sex determining region of the Y (SRY).


Development of urogenital system

Endoderm cell of yolk sac

Proliferation differentiation

3rd to 4th week

Promordial germ cells

Migration in 1 week

6th week

6th week

Gonadal ridge

Primitive sex cord

Superfacail epithelium →cell cord

  • Development of

  • undifferentiated gonad


Development of urogenital system

Promordial germ cells

Large and round endoderm cells in yolk sac


Development of urogenital system

Dorsal mesentary of the gut

Migration of promordial germ cells


Development of urogenital system

Seperated from surface

7th week

Seminiferous tubule

Mesenchymal cells

Cells of sex cord

Promordial germ cells

Spermatogonium

Interstitial cells

Sustantacular cells

Testis

2. Development of testis

Primary sex cord(TDF)


Development of urogenital system

Superfacial epithelium

No TDF

Primary sex cord

After 8 weeks

Secondary sex cord (Cortical cord)

16th week

Degeneration

Mesenchymal cells

Primordial follicel

Primordial germ cells

Cells of sex cord

Ooginum

Stroma

Follicular cells

Ovary

3. Development of ovary


Development of urogenital system

Ovary

Testis

Rete testis

Tubule rectus

Follicle

Seminiferous tubule

Spermatogonium

Primary oocyte

Sustantacular cell

Follicular cell

Follicle

Seminiferous tubule


Development of urogenital system

4. Descend of testis and ovary


Development of urogenital system

Development of reproductive tracts

1. Undifferentiated stage


Development of urogenital system

2. Differentiation of male reproductive tract

Proximal part ── epididymal duct

Distal part── ductus deferens and ejaculatory duct

Mesonephric duct

Most of ── degeneration

Some of ── efferent ducts

Mesonephric tubule

Paramesonephric duct

Regression

──


Development of urogenital system

3. Differentiation of female reproductive tract

Upper and middle segment:oviduct

Lower segment: uterus

Paramesonephric duct

Vagina

Sinus tubercle:

Vaginal plate

Mesonephric duct and tubule

regression


Development of urogenital system

Abnormality of reproductive system

1. Cryptorchidism


Development of urogenital system

2. Congenital inguinal

hernia

3. Double uterus


Development of urogenital system

4. Vaginal atresia

5. Hypospadias


Development of urogenital system

6. Hermaphroditism


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