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STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS - Update of the INTRASTENT registry -. W. Kurre Klinik für Neuroradiologie - Alfried Krupp Krankenhaus Essen J. Berkefeld Institut für Neuroradiologie - Goethe Universität Frankfurt FOR THE INTRASTENT STUDY GROUP 07.10.2010. COINVESTIGATORS.

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slide1

STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS

- Update of the INTRASTENT registry -

W. Kurre

Klinik für Neuroradiologie - Alfried Krupp Krankenhaus Essen

J. Berkefeld

Institut für Neuroradiologie - Goethe Universität Frankfurt

FOR THE INTRASTENT STUDY GROUP

07.10.2010

slide2

COINVESTIGATORS

Universitätsklinik Kiel O. Jansen / M. Tietke

AK Altona Hamburg B. Eckert

Universitätsklinik Hamburg O. Wittkugel / J. Fiehler

University of Oxford W. Küker

Universitätsklinik Göttingen M. Knauth / S. Pilgram / R. Schramm

Universitätsklinik Düsseldorf B. Turowski

Wedau Kliniken Duisburg F. Brassel / S. Schotes / D. Meila

Helios Klinikum Erfurt J. Klisch / V. Sychra

Universitätsklinik Dresden R. v. Kummer / D. Mucha

Universitätsklinik Frankfurt J. Berkefeld / W. Kurre/ S. Kamek

Universitätsklinik Mainz W. Müller-Forell

München Rechts der Isar Th. Liebig / F. Dorn

Military Hosptial Prague J. Maskova / H. Parobkova

Landesnervenklinik Wagner-Jauregg Linz J. Trenkler / H. Haring

Universitätsklinik Graz G. Klein / K. Niederkorn

Papanikolaou General Hospital Greece V. Katsaridis

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TECHNICAL SUCCESS

OVERALL SUCCESS: 89.7%

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MORBIDITY / MORTALITY

% as per procedure

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HEMORRHAGE

Significantlymorehemorrhagesfor M1 stenosescompared to otherlocations!

slide8

ISCHAEMIA

Moreperforatorstrokes in posteriorcirculation

location of stenosis1
LOCATION OF STENOSIS

Differences NOT statisticallysignificant

devices used
DEVICES USED

Significantlymore SE in dICA and M1

Moreprospectivedatafor SE

complications device
COMPLICATIONS - DEVICE
  • datanotrandomized
  • significantlymore SE in dICA and M1
  • - moreprospectivedatafor SE
  • p = 0.054 fordisabelingstroke and death
complications device1
COMPLICATIONS - DEVICE
  • datanotrandomized
  • - moreprospectivedatafor SE
  • p = 0.23 and 0.2 forintra- and extradural BE vs. SE
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CLINICAL FOLLOW UP

FU rate 68.5%

median FU 312 Tage

slide15

ANGIOGRAFIC FOLLOW UP

22.6% control angiography

selected patients!

summary
SUMMARY
  • disabeling stroke and death 6.4%
  • TIA and nondisabeling stroke 4.9%
    • Increasing complication rates in intradural locations (n.s.)
    • significantly more hemorrhages in treatment of M1 stenoses
    • complication rates for SES higher for intra- and extradural locations (n.s., bias!)
  • ipsilateral stroke rate FU 3%
  • (CAVE: 68.5% follow up, median 312 days)
  • rate of restenosis 32.1%
  • (CAVE: 22.6% follow up)
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