STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS
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STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS - Update of the INTRASTENT registry -. W. Kurre Klinik für Neuroradiologie - Alfried Krupp Krankenhaus Essen J. Berkefeld Institut für Neuroradiologie - Goethe Universität Frankfurt FOR THE INTRASTENT STUDY GROUP 07.10.2010. COINVESTIGATORS.

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STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS - Update of the INTRASTENT registry -

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STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS

- Update of the INTRASTENT registry -

W. Kurre

Klinik für Neuroradiologie - Alfried Krupp Krankenhaus Essen

J. Berkefeld

Institut für Neuroradiologie - Goethe Universität Frankfurt

FOR THE INTRASTENT STUDY GROUP

07.10.2010


COINVESTIGATORS

Universitätsklinik KielO. Jansen / M. Tietke

AK Altona HamburgB. Eckert

Universitätsklinik HamburgO. Wittkugel / J. Fiehler

University of OxfordW. Küker

Universitätsklinik GöttingenM. Knauth / S. Pilgram/ R. Schramm

Universitätsklinik DüsseldorfB. Turowski

Wedau Kliniken DuisburgF. Brassel / S. Schotes / D. Meila

Helios Klinikum ErfurtJ. Klisch / V. Sychra

Universitätsklinik DresdenR. v. Kummer / D. Mucha

Universitätsklinik FrankfurtJ. Berkefeld / W. Kurre/ S. Kamek

Universitätsklinik MainzW. Müller-Forell

München Rechts der IsarTh. Liebig / F. Dorn

Military Hosptial PragueJ. Maskova/ H. Parobkova

Landesnervenklinik Wagner-Jauregg LinzJ. Trenkler / H. Haring

Universitätsklinik GrazG. Klein / K. Niederkorn

Papanikolaou General Hospital GreeceV. Katsaridis


INCLUSION CRITERIA


LOCATION OF STENOSIS


TECHNICAL SUCCESS

OVERALL SUCCESS: 89.7%


MORBIDITY / MORTALITY

% as per procedure


HEMORRHAGE

Significantlymorehemorrhagesfor M1 stenosescompared to otherlocations!


ISCHAEMIA

Moreperforatorstrokes in posteriorcirculation


OTHER


LOCATION OF STENOSIS

Differences NOT statisticallysignificant


DEVICES USED

Significantlymore SE in dICA and M1

Moreprospectivedatafor SE


COMPLICATIONS - DEVICE

  • datanotrandomized

  • significantlymore SE in dICA and M1

  • - moreprospectivedatafor SE

  • p = 0.054 fordisabelingstroke and death


COMPLICATIONS - DEVICE

  • datanotrandomized

  • - moreprospectivedatafor SE

  • p = 0.23 and 0.2 forintra- and extradural BE vs. SE


CLINICAL FOLLOW UP

FU rate 68.5%

median FU 312 Tage


ANGIOGRAFIC FOLLOW UP

22.6% control angiography

selected patients!


SUMMARY

  • disabeling stroke and death6.4%

  • TIA and nondisabeling stroke4.9%

    • Increasing complication rates in intradural locations (n.s.)

    • significantly more hemorrhages in treatment of M1 stenoses

    • complication rates for SES higher for intra- and extradural locations (n.s., bias!)

  • ipsilateral stroke rate FU3%

  • (CAVE: 68.5% follow up, median 312 days)

  • rate of restenosis32.1%

  • (CAVE: 22.6% follow up)


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