STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS
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STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS - Update of the INTRASTENT registry -. W. Kurre Klinik für Neuroradiologie - Alfried Krupp Krankenhaus Essen J. Berkefeld Institut für Neuroradiologie - Goethe Universität Frankfurt FOR THE INTRASTENT STUDY GROUP 07.10.2010. COINVESTIGATORS.

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STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS - Update of the INTRASTENT registry -

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Stent treatment of intracranial atherosclerosis update of the intrastent registry

STENT TREATMENT OF INTRACRANIAL ATHEROSCLEROSIS

- Update of the INTRASTENT registry -

W. Kurre

Klinik für Neuroradiologie - Alfried Krupp Krankenhaus Essen

J. Berkefeld

Institut für Neuroradiologie - Goethe Universität Frankfurt

FOR THE INTRASTENT STUDY GROUP

07.10.2010


Stent treatment of intracranial atherosclerosis update of the intrastent registry

COINVESTIGATORS

Universitätsklinik KielO. Jansen / M. Tietke

AK Altona HamburgB. Eckert

Universitätsklinik HamburgO. Wittkugel / J. Fiehler

University of OxfordW. Küker

Universitätsklinik GöttingenM. Knauth / S. Pilgram/ R. Schramm

Universitätsklinik DüsseldorfB. Turowski

Wedau Kliniken DuisburgF. Brassel / S. Schotes / D. Meila

Helios Klinikum ErfurtJ. Klisch / V. Sychra

Universitätsklinik DresdenR. v. Kummer / D. Mucha

Universitätsklinik FrankfurtJ. Berkefeld / W. Kurre/ S. Kamek

Universitätsklinik MainzW. Müller-Forell

München Rechts der IsarTh. Liebig / F. Dorn

Military Hosptial PragueJ. Maskova/ H. Parobkova

Landesnervenklinik Wagner-Jauregg LinzJ. Trenkler / H. Haring

Universitätsklinik GrazG. Klein / K. Niederkorn

Papanikolaou General Hospital GreeceV. Katsaridis


Inclusion criteria

INCLUSION CRITERIA


Location of stenosis

LOCATION OF STENOSIS


Stent treatment of intracranial atherosclerosis update of the intrastent registry

TECHNICAL SUCCESS

OVERALL SUCCESS: 89.7%


Stent treatment of intracranial atherosclerosis update of the intrastent registry

MORBIDITY / MORTALITY

% as per procedure


Stent treatment of intracranial atherosclerosis update of the intrastent registry

HEMORRHAGE

Significantlymorehemorrhagesfor M1 stenosescompared to otherlocations!


Stent treatment of intracranial atherosclerosis update of the intrastent registry

ISCHAEMIA

Moreperforatorstrokes in posteriorcirculation


Stent treatment of intracranial atherosclerosis update of the intrastent registry

OTHER


Location of stenosis1

LOCATION OF STENOSIS

Differences NOT statisticallysignificant


Devices used

DEVICES USED

Significantlymore SE in dICA and M1

Moreprospectivedatafor SE


Complications device

COMPLICATIONS - DEVICE

  • datanotrandomized

  • significantlymore SE in dICA and M1

  • - moreprospectivedatafor SE

  • p = 0.054 fordisabelingstroke and death


Complications device1

COMPLICATIONS - DEVICE

  • datanotrandomized

  • - moreprospectivedatafor SE

  • p = 0.23 and 0.2 forintra- and extradural BE vs. SE


Stent treatment of intracranial atherosclerosis update of the intrastent registry

CLINICAL FOLLOW UP

FU rate 68.5%

median FU 312 Tage


Stent treatment of intracranial atherosclerosis update of the intrastent registry

ANGIOGRAFIC FOLLOW UP

22.6% control angiography

selected patients!


Summary

SUMMARY

  • disabeling stroke and death6.4%

  • TIA and nondisabeling stroke4.9%

    • Increasing complication rates in intradural locations (n.s.)

    • significantly more hemorrhages in treatment of M1 stenoses

    • complication rates for SES higher for intra- and extradural locations (n.s., bias!)

  • ipsilateral stroke rate FU3%

  • (CAVE: 68.5% follow up, median 312 days)

  • rate of restenosis32.1%

  • (CAVE: 22.6% follow up)


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