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Rhabdoviruse family Rhabdo ( Rod) Rabies virus

Rhabdoviruse family Rhabdo ( Rod) Rabies virus. Rabies. Acute CNS infection of warm-blooded animals. (Dogs, cats, wolfes, foxes, cattles, bats ). Rabies virus. BULLET-SHAPED ( 1 flat end and 1 round end) ss RNA NON SEGMENTED ENVELOPED 1 serotype & 2 biotypes ( street & Fixed ).

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Rhabdoviruse family Rhabdo ( Rod) Rabies virus

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  1. Rhabdoviruse familyRhabdo ( Rod)Rabies virus

  2. Rabies • Acute CNS infection of warm-blooded animals. (Dogs, cats, wolfes, foxes, cattles, bats)

  3. Rabies virus BULLET-SHAPED (1 flat end and 1 round end) ss RNA NON SEGMENTED ENVELOPED 1 serotype & 2 biotypes (street & Fixed)

  4. Rabies Virus

  5. Moods of transmission • Bite of rabid animal(Zoonotic) through infected saliva. Virus migrates up peripheral nerves to the spinal cord and ends in the brain with no viraemia<<<< the salivary glands(Saliva) & the cornea • Non bite transmission • Aerosol transmission from bats. • Organ donations: in 2004, 4 cases in USA documented from corneal transplantation. • Contamination of an open wound or a mucous membrane

  6. Incubation of Rabies • Averages 2 - 16 weeks • Can be as short as 1 week or up to 1 year • The two most important factors in incubation of the virus are • Bite location & severity & • amount of the viruses

  7. In Humans • fever, headache, and general weakness or discomfort. • insomnia, anxiety, confusion, slight or partial paralysis, excitation, hallucinations, hypersalivation difficulty in swallowing, and hydrophopia (fear of water). • Convulsions, paralysis, coma, Death.

  8. In unvaccinated humans, rabies is almost always fatal after neurological symptoms have developed, But ????? rapid post-exposure vaccination may prevent the virus from progressing

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