the wonderful duplicating machine
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The wonderful duplicating “machine”. 18xx Interphase-Mitosis (Flemming) 1951 Discovery of a distinct S-phase (Howard and Pelc) 1970 Cell fusion experiments (Rao and Johnson) 1971 Discovery of MPF (Masui and Markert) 197x Yeast cdc mutants (Nurse, Hartwell etc.)

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a briefe history of the cell cycle
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

A briefe history of the cell cycle
slide3
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

slide10
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

slide18
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase ()

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

slide22
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

slide27
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

slide38
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

slide41
18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

cdc2 28 cdk1 is regulated by
Cdc2/28 (=cdk1) is regulated by:

1. Binding of a cyclin2. Inhibitory phosphorylation3. Activating phosophorylation4. Binding of CKI5. Cellular localization

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