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The wonderful duplicating “machine”. 18xx Interphase-Mitosis (Flemming) 1951 Discovery of a distinct S-phase (Howard and Pelc) 1970 Cell fusion experiments (Rao and Johnson) 1971 Discovery of MPF (Masui and Markert) 197x Yeast cdc mutants (Nurse, Hartwell etc.)

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A briefe history of the cell cycle

18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)

A briefe history of the cell cycle


18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)


18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)






18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase ()

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)


Cell fusion experiment johnson and rao 1971

G1

M

M

Cell fusion experimentJohnson and Rao 1971

S

M

M

G2

M

M


18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)


Maturation promoting factor

cytostatic factor


Discovery of mpf masui and markert 1971
Discovery of MPFMasui and Markert 1971



18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)










18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)


18xx Interphase-Mitosis (Flemming)

1951 Discovery of a distinct S-phase (Howard and Pelc)

1970 Cell fusion experiments (Rao and Johnson)

1971 Discovery of MPF (Masui and Markert)

197x Yeast cdc mutants (Nurse, Hartwell etc.)

1983 Discovery of the first cyclins (Hunt)

1988 Cyclin B+cdc2 = MPF (Maller, Newport, Beach)





Cdc2 28 cdk1 is regulated by
Cdc2/28 (=cdk1) is regulated by: activity

1. Binding of a cyclin2. Inhibitory phosphorylation3. Activating phosophorylation4. Binding of CKI5. Cellular localization


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