EURAMOS 1

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EURAMOS. EURAMOS is the European and American Osteosarcoma Study Group. The study was founded in 2001.Children\'s Oncology GroupCooperative Osteosarcoma Study GroupEuropean Osteosarcoma IntergroupScandinavian Sarcoma Group. EURAMOS. Established Oct 2001Aim to improve survival from OSObjecti
EURAMOS 1

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1. EURAMOS 1 A randomised trial of the European and American Osteosarcoma Study Group to optimize treatment strategies for resectable osteosarcoma based on histological response to pre-operative chemotherapy

2. EURAMOS EURAMOS is the European and American Osteosarcoma Study Group. The study was founded in 2001. Children?s Oncology Group Cooperative Osteosarcoma Study Group European Osteosarcoma Intergroup Scandinavian Sarcoma Group

3. EURAMOS Established Oct 2001 Aim to improve survival from OS Objectives to carry out large international randomised trials to facilitate biological research to seek new therapeutic approaches to develop common understanding and methodologies for staging, pathology etc.

4. EURAMOS 1 Co-sponsored MRC in Europe COG for North America Co-ordinating Data Centre MRC Clinical Trials Unit

5. Trial Design

6. Trial Design Key registration criteria High grade OS of extremity or axial skeleton Resectable disease Fit for treatment

7. Trial Design Key randomisation criteria Adequate pre-operative chemotherapy Macroscopically complete resection of primary tumour Complete removal of all metastases or complete removal planned and feasible Histological response assessment

8. Trial Design Primary Objectives Addition of IE to post-op MAP chemotherapy improves EFS for poor responders Addition of ifn to post-op MAP chemotherapy improves EFS for good responders

9. Trial Design Secondary Objectives Additional treatment improves OS, short and long term toxicity and quality of life Additional treatment improves EFS in localised disease Investigate biological and clinical correlated to histological response and outcome International cooperation in trials Examine outcome of the entire cohort of patients ????????????????

10. Trial Design- additional studies Quality of Life Biology Studies

11. EURAMOS participants

12. Progress: open and recruiting

13. Progress: almost ready Austria Finland

14. Progress: requests to join Czech Republic Ireland Poland Israel

15. Accrual

16. Accrual

17. Accrual

18. EURAMOS 1 Chief Investigators Mark Bernstein (TMG Chair) Neyssa Marina (COG) Stephan Bielack (COSS) Jeremy Whelan (EOI) Sigbjorn Smeland (SSG) Website www.euramos.org



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