Overview of my research
This presentation is the property of its rightful owner.
Sponsored Links
1 / 10

Overview of My Research PowerPoint PPT Presentation


  • 70 Views
  • Uploaded on
  • Presentation posted in: General

Overview of My Research. Brendan Mumey Department of Computer Science MSU. Interest: Algorithms. In Computational Biology… Epitope mapping In Networking… Optical networking (NSF supported) Wireless networking. Background: Antibody Imprinting .

Download Presentation

Overview of My Research

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Overview of my research

Overview of My Research

Brendan Mumey

Department of Computer Science

MSU


Interest algorithms

Interest: Algorithms

  • In Computational Biology…

    • Epitope mapping

  • In Networking…

    • Optical networking (NSF supported)

    • Wireless networking


Background antibody imprinting

Background: Antibody Imprinting

  • Step 1: Find an antibody that binds the protein:

    Step 2: Probe the antibody with a random peptide library of short peptide sequences:

protein

target

antibody

probes

antibody


Validation case antibody 9d7 epitope on il 10

15%

85%

Validation case: Antibody 9D7 epitope on IL-10


Overview of my research

  • The grey squares are the alignment of a random set of peptides

  • The gold triangles are the genuine epitope

  • The large yellow triangles are key residues mediating binding of antibody to antigen


Current work

Current Work

  • Improving algorithm to do multiple alignments

  • Refining substitution matrix based on PDB data


Optical networking

Optical Networking

NSF Optical Network


Routing and wavelength assignment

Routing and Wavelength Assignment


Markov based rwa results

Markov based RWA results


Current work1

Current Work

  • Extending some ideas from Multicommodity Flow for improved algorithms

  • New software simulation system (RAPTOR) for testing RWA algorithms with physical impairments modeled


  • Login