Enhancing myosin activation and cardiac contractility implications for heart failure
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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure PowerPoint PPT Presentation


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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure. Heart Failure. Traditional Treatment for Acute Decompensated Heart Failure. Traditional Treatment for Acute Decompensated Heart Failure (cont).

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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure

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Enhancing myosin activation and cardiac contractility implications for heart failure

Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure


Heart failure

Heart Failure


Traditional treatment for acute decompensated heart failure

Traditional Treatment for Acute Decompensated Heart Failure


Traditional treatment for acute decompensated heart failure cont

Traditional Treatment for Acute Decompensated Heart Failure (cont)


Traditional treatment for acute decompensated heart failure cont1

Traditional Treatment for Acute Decompensated Heart Failure (cont)


Traditional positive inotropic agents

Traditional Positive Inotropic Agents


Omecamtiv mecarbil a novel selective cardiac myosin activator

Omecamtiv Mecarbil: A Novel Selective Cardiac Myosin Activator


Omecamtiv mecarbil

Omecamtiv Mecarbil


Omecamtiv mecarbil echocardiogram changes in healthy volunteers

Omecamtiv Mecarbil: Echocardiogram Changes in Healthy Volunteers


Enhancing myosin activation and cardiac contractility implications for heart failure

Omecamtiv Mecarbil: Echocardiographic Changes in Patients With Stable Heart Failure and LV Dysfunction


Atomic ahf study design randomized double blind placebo controlled sequential cohort study

ATOMIC-AHF: Study DesignRandomized, Double-blind, Placebo-controlled, SequentialCohort Study


Atomic ahf primary end point dyspnea response paired placebo

ATOMIC-AHF-Primary End Point:Dyspnea ResponsePaired Placebo


Safety concerns

Safety Concerns


Supraventricular and ventricular tachyarrhythmias

Supraventricular and Ventricular Tachyarrhythmias


Cosmic hf chronic oral study of myosin activation to increase contractility in heart failure

COSMIC-HF: Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure


References

References


Abbreviations

Abbreviations


Abbreviations cont

Abbreviations (cont)


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