Enhancing myosin activation and cardiac contractility implications for heart failure
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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure PowerPoint PPT Presentation


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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure. Heart Failure. Traditional Treatment for Acute Decompensated Heart Failure. Traditional Treatment for Acute Decompensated Heart Failure (cont).

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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure

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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure


Heart Failure


Traditional Treatment for Acute Decompensated Heart Failure


Traditional Treatment for Acute Decompensated Heart Failure (cont)


Traditional Treatment for Acute Decompensated Heart Failure (cont)


Traditional Positive Inotropic Agents


Omecamtiv Mecarbil: A Novel Selective Cardiac Myosin Activator


Omecamtiv Mecarbil


Omecamtiv Mecarbil: Echocardiogram Changes in Healthy Volunteers


Omecamtiv Mecarbil: Echocardiographic Changes in Patients With Stable Heart Failure and LV Dysfunction


ATOMIC-AHF: Study DesignRandomized, Double-blind, Placebo-controlled, SequentialCohort Study


ATOMIC-AHF-Primary End Point:Dyspnea ResponsePaired Placebo


Safety Concerns


Supraventricular and Ventricular Tachyarrhythmias


COSMIC-HF: Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure


References


Abbreviations


Abbreviations (cont)


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