Tissue Viability Imager – TiVi600. The non-invasive technology that can ”see through” the top layer of the skin and collect information about the status of the underlying tissue. Skin testing. Drug development. Development of skin care products and cosmetics Microvascular research.
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Tissue Viability Imager – TiVi600
The non-invasive technology that can ”see through” the top layer of the skin and collect information about the status of the underlying tissue.
Development of skin care products and cosmetics
tissue viability image
red light is moderately absorbed by
green light is highly absorbed by RBCs
A transparent tubing system filled with RBCs of different concentration is used for modelling the skin microcirculation.
Simulated and measured TiVi-index versus RBC fraction
A linear relationship is
attained between RBC concentration and TiVi output signal.
Small and portable design.
12 images per minute.
2D color presentation.
Basic data availability.
Non-invasive and remote operation.
Instantaneous image capturing.
Not sensitive to movements or ambient light.
Does not influnce the microcirculation.
Calibration not necessary.
Before application of
About ten minutes
following application of
Select regions of interest.
Display the Erythema
Analysis of time series
Build a video out
of 100 images.
Select a cross-section.
Display the TiVi values along the cross-section versus time.
Analysis of time series
0.5 mg/ml clobestal proprionate
50 mmol methyl nicotinate (20 microliter).
The average TiVi-values for the erythema, blanching and control area.
Erythema and Blanching
Step 1. Drug application by iontophoresis.
Step 2. Capture a sequence of images through the ring-shape iontophoresis electrode and watch the result.
Step 3. Display the time-sequence of average TiVi-values.
Step 4. Generate a dose-response curve.
Transcutaneous drug delivery
Tissue Viability Imaging Laser Doppler Perfusion Imaging
TiVi Quantity LDPI
RBC conc Measurand RBC vel * conc
none Movement artifact sensitivity high
up to 9.000.000 No. ofmeasurement points up to 65.000
low Ambient light sensitivity high
instantaneous Image capturing time minutes
good Portability poor
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