Antigen capture
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Antigen capture. B cell expansion. Immature DC. T cell expansion. PAMP recognition and activation. Mature DC. Figure 1. DC activation and maturation. Adapted from Wack, A. and Rappuoli, R. Current Opinions in Immunology 2005. Figure 2. Human DC subsets and lineage origins.

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Mature DC

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Mature dc

Antigen capture

B cell expansion

Immature DC

T cell expansion

PAMP recognition

and activation

Mature DC

Figure 1. DC activation and maturation.

Adapted from Wack, A. and Rappuoli, R. Current Opinions in Immunology 2005


Mature dc

Figure 2. Human DC subsets and lineage origins.

Shortman, K and Y. J. Liu Nature Reviews Immunology 2002


Mature dc

Figure 3. Within the immune synapse formed between APCs and T cells, three signals are required for antigen-specific T cell activation.

Gutcher, I. and Becher, B. Journal of Clinical Investigation 2007


Mature dc

Figure 4. APC-derived cytokines guide the differentiation of naive T cells into an effector T cell subtypes in mouse.

Gutcher, I. and Becher, B. Journal of Clinical Investigation 2007


Mature dc

Figure 5. Structures of the IL-1R family.

Sims, J. et al Current Opinions in Immunology 2007


Mature dc

Figure 6. TLRs localization and their ligands.

Verstak, B. et al Inflammation Research 2007

Table 1. Synthetic and endogenous TLR ligands.

Kanzler, H. et al Nature Medicine 2007


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Figure 7. IRF Activation by Cytosolic Pattern-Recognition Systems; Operation of a Positive-Feedback Mechanism.

Honda, K. et al Immunity 2006


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Figure 8. Summary of TLR signaling pathways.

Dunne, A. and O’Neill, L. FEBS Letters 2005


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TRIF

TRIF

TBK1

IKKe

Figure 9. Type I IFN positive feedback loop.

Adapted from Doyle, S. et al, Immunity 2002


Mature dc

Figure 10. Schematic representation of IRF-3 and IRF-7 activation and dimerization by virus-induced phosphorylation. Lin, R. et al. Cellular and Molecular Biology 1999


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Figure 11. Enhanceosome formation and IFN-β gene transcription.

Kenya, H. et al Immunity 2006


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Figure 12. IL-12 family members: composition, receptors and regulatory functions.

Adapted fromGoriely, S. and Goldman, M. Transplantation 2007


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IL-23

IL-27

Figure 13. Regulatory functions of IL-27.

Adapted from Colgan, J. and Rothman, P. Nature Immunology 2006


Mature dc

Figure 14. The classification and structure of the PKC family of isozymes.

Kheifets, V. and Mochly-Rosen, D. Pharmacological Research 2007


Mature dc

Figure 15. Model of PKCα phosphorylation.

Bornancin, F. and Parker, P.J. Journal of Current Biology 1996


Mature dc

Adapted from

TLR3

PKCa

IL-12/23p40

IL-23p19

IL-12p35

IL-27p28

Figure 16. Schematic of PKCa activity in TLR3 and TLR4 signaling pathways.

Adapted from Akira, S. and Takeda, K. Nature Reviews Immunology 2004


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