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15.1 Origin of Life. There are three possibilities for the appearance of the first living organisms on Earth 1. Extraterrestrial origin Life was transferred to Earth from a distant planet 2. Special creation Life was created by supernatural or divine forces 3. Evolution

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15 1 origin of life
15.1 Origin of Life

  • There are three possibilities for the appearance of the first living organisms on Earth

    • 1. Extraterrestrial origin

      • Life was transferred to Earth from a distant planet

    • 2. Special creation

      • Life was created by supernatural or divine forces

    • 3. Evolution

      • Life may have evolved from inanimate matter, with selection as the driving force

    • Only the third possibility is scientifically testable


Forming life s building blocks

Fig. 15.1

Forming Life’s Building Blocks

  • Life originated 2.5 billion years ago

    • The Earth’s atmosphere then had no oxygen

      • It was rich with hydrogen-rich gases (NH3, CH4)

  • These simple molecules combined to form more complex molecules

    • Lightning provided the energy


Forming life s building blocks1
Forming Life’s Building Blocks

  • Stanley Miller and Harold Urey reconstructed the oxygen-free atmosphere of early Earth in their lab

    • Cellular building blocks form spontaneously, when the system is subjected to lightning or UV light

      • They concluded that life may have evolved in a “primordial soup” of biological molecules


Forming life s building blocks2
Forming Life’s Building Blocks

  • Concerns have been raised about the “primordial soup” hypothesis

    • No oxygen => no protective ozone layer

      • Therefore, the UV light would have destroyed the essential ammonia and methane gases

  • Louis Lerman, in 1986, proposed the bubble model

    • Key chemical life-building processes took place within bubbles on the ocean’s surface

      • Inside the bubbles the essential gases would be protected from UV light



15 2 how cells arose
15.2 How Cells Arose

  • The first step may have been the formation of tiny bubbles termed microspheres

    • These have cell-like properties

  • Those microspheres better able to incorporate molecules and energy persisted longer than others

  • The first macromolecule produced was RNA

    • It provided a possible early mechanism of inheritance

  • Later, RNA was replaced as hereditary material by the much more stable double-stranded DNA


Earth is formed 4.5 billion years ago

Fig. 15.3 A clock of biological time


15 3 the simplest organisms
15.3 The Simplest Organisms

  • The fossil record indicates that prokaryotes appeared 2.5 billion years ago

    • Eukaryotes, on the other hand, appeared only 1.5 billion years ago

  • Today prokaryotes are the simplest and most abundant form of life on earth

  • Prokaryotes occupy a very important place in the web of life in earth


The structure of a prokaryote

Spiral

Rod

Fig. 4.9

Spherical

The Structure of a Prokaryote

  • Prokaryotes are small, simply organized, single cells that lack a nucleus

  • Prokaryotes include the bacteria and archaebacteria

  • They come in three main shapes

    • Rod-shaped (bacilli)

    • Spherical (cocci)

    • Spirally coiled (spirilli)


The structure of a prokaryote1
The Structure of a Prokaryote

  • The cell membrane of prokaryotes is encased in a cell wall

  • Bacterialcell walls are composed ofpeptidoglycan

    • Network of polysaccharides linked together by peptide cross-links

  • Archaebacterialcell walls lack peptidoglycan

    • They are made of proteins, sugars or both


  • Gram-positive

    • Have a thick peptidoglycan layer

    • Lack outer membrane

  • Gram-negative

    • Have a thin peptidoglycan layer

    • Have an outer membrane containing lipopolysaccharide

  • Bacteria can be divided into two groups based on their cell wall architecture

The name refers to a differential stain developed by Hans Christian Gram

  • Gram-positive cells retain the primary crystal violet stain

  • Gram-negative cells don’t and are stained by a safranin (red) counterstain


Fig. 15.4 The structure of bacterial cell walls


  • Many bacteria have capsules

    • A gelatinous layer found external to the cell wall

  • Many bacteria possess threadlike flagella

    • Long external appendages used for locomotion

  • Some bacteria also possess pili

    • Short external appendages used for attachment

  • In harsh conditions, a few bacteria can form endospores

    • Highly-resistant structures that may germinate into active bacteria when conditions improve


Fig. 7.1

  • Prokaryotes reproduce by binary fission


Fig. 15.5

Both cells contain a complete copy of the plasmid

  • Some bacteria undergo a process called conjugation

    • The undirectional transfer of plasmid DNA following cell-to-cell contact

Pilus connecting the two cells together


15 4 comparing prokaryotes to eukaryotes

Prokaryotes differ from eukaryotes in many respects

They have very little internal organization

They are unicellular and much smaller

They possess a single chromosome

They are far more metabolically diverse

15.4 Comparing Prokaryotes to Eukaryotes


Prokaryotic metabolism
Prokaryotic Metabolism

  • Prokaryotes have evolved many more ways than eukaryotes to acquire carbon and energy

    • Acquisition of Carbon

      • Autotrophs = Use CO2 as their only carbon source

      • Heterotrophs = Use preformed organic compounds as carbon sources

    • Acquisition of Energy

      • Phototrophs = Use light as energy source

      • Chemotrophs = Use chemicals as energy source


Prokaryotic metabolism1
Prokaryotic Metabolism

  • Based on carbon and energy sources, prokaryotes can be divided into four categories

  • 1. Photoautotrophs

    • Use the energy of sunlight to build organic molecules from CO2

    • Cyanobacteria

  • 2. Chemoautotrophs

    • Obtain energy by oxidizing inorganic substances

    • Nitrifiers oxidize ammonia or nitrite


Prokaryotic metabolism2
Prokaryotic Metabolism

  • Based on carbon and energy sources, prokaryotes can be divided into four categories

  • 3. Photoheterotrophs

    • Use light as energy and pre-formed organic molecules as carbon sources

    • Purple nonsulfur bacteria

  • 4. Chemoheterotrophs

    • Use organic molecules as carbon and energy sources Decomposers and most pathogens


15 5 importance of prokaryotes
15.5 Importance of Prokaryotes

  • Prokaryotes were largely responsible for creating the properties of the atmosphere and soil found on Earth

  • They are the principal decomposers

  • They are the only organisms capable of fixing nitrogen, thus making it available for others

  • They cause major diseases in plants and animals, including humans


Fig. 15.7

Exxon Valdez oil spill

  • Prokaryotes are instrumental in genetic engineering

    • Nonpolluting insect control agents

    • Removing environmental pollutants


15 6 prokaryotic lifestyles
15.6 Prokaryotic Lifestyles

  • Prokaryotes belong to two domains

    • Archaea

      • Members are termed archaebacteria

    • Bacteria

      • Members are termed bacteria

      • Includes the vast majority of prokaryotes described


15 6 prokaryotic lifestyles1

Hot spring in Yellowstone National Park

Fig. 15.8

15.6 Prokaryotic Lifestyles

  • Archaeabacteria include

    • Methanogens

      • Use H2 to reduce CO2 to CH4

      • Live in swamps and marshes

    • Extremophiles

      • Live in unusually harsh environments

      • Thermoacidophiles

        • Hot and acidic environments


15 6 prokaryotic lifestyles2

Fig. 15.9

15.6 Prokaryotic Lifestyles

  • Bacteria include

    • Cyanobacteria

      • Individual cells adhere in filaments

      • The most prominent photosynthetic bacteria

      • Also capable of nitrogen fixation

        • In specialized cells called heterocysts

Heterocysts


15 6 prokaryotic lifestyles3
15.6 Prokaryotic Lifestyles

  • There are numerous phyla of non-photosynthetic bacteria

    • Some are chemoautotrophs

    • But most are heterotrophs

      • Decomposers

  • Bacteria cause many diseases in humans

    • Among the most serious is tuberculosis (TB)

      • It is caused by Mycobacterium tuberculosis

        • The emergence of drug-resistant strains in the 1990s has raised serious medical concerns


15 7 the structure of viruses
15.7 The Structure of Viruses

  • Viruses are not living organisms

    • Rather, they are “parasitic” chemicals that can only reproduce within living cells

  • Viruses are very small

    • Range from 17 – 1,000 nm

  • Viruses occur in all organisms

    • In every case, the basic structure is the same

      • Segments of DNA or RNA wrapped in a protein coat called the capsid

    • There is considerable difference, however, in the details


Membrane-like layer

Fig. 15.10 The structure of bacterial, plant and animal viruses

Not found in all viruses

Capsid


15 8 how bacteriophages enter prokaryotic cells

Bacteriophages are viruses that infect bacteria

The most studied are double-stranded DNA bacteriophages, including

Phage T4

Fig. 15.11b

15.8 How Bacteriophages Enter Prokaryotic Cells

Tail fibers

  • Phage lambda (l)

    • Same basic structure as T4

    • But only possesses one thin tail fiber


15 8 how bacteriophages enter prokaryotic cells1

Bacteriophages undergo two types of reproductive cycles

Lytic cycle

Example:

T4 bacteriophage

Lysogenic cycle

Example:

Bacteriophage l

15.8 How Bacteriophages Enter Prokaryotic Cells


Lytic cycle
Lytic Cycle

  • Bacteriophage uses tail fibers to attach to bacterial cell wall

  • Tail contracts and DNA is injected into host cytoplasm

  • Viruses multiply within infected cell

  • They eventually lyse (rupture) the cell and spread to other cells

  • Viruses that can only undergo a lytic cycle are termed virulent


Uninfected cell

Lysis of cell

Bacterial chromosome

Assembly of new

viruses using bacterial

cell machinery

Virus attaching

to cell wall

Lytic

cycle

Replication

of virus

Viral DNA

injected into cell

Fig. 15.12 Lytic and lysogenic cycles of a bacteriophage


Lysogenic cycle
Lysogenic Cycle

  • Some bacteriophages do not immediately kill the cells they infect

    • Rather, they integrate their DNA into the chromosome of their host cell

      • This phenomenon is termed lysogeny

      • The viral DNA is called the prophage

  • At a later time, the prophage may exit the genome

    • This initiates viral replication and, ultimately, cell lysis

  • Viruses that can become stably integrated within their host’s genome are termed temperate


Uninfected cell

Lysis of cell

Bacterial chromosome

Assembly of new

viruses using bacterial

cell machinery

Virus attaching

to cell wall

Lytic

cycle

Replication

of virus

Viral DNA

injected into cell

Reduction to

prophage

Prophage exits the

bacterial chromosome

Lysogenic

cycle

Reproduction of lysogenic bacteria

Fig. 15.12 Lytic and lysogenic cycles of a bacteriophage

Viral DNA integrated

into bacterial chromosome


Lysogenic conversion
Lysogenic Conversion

  • Expression of prophage genes may have an important effect on the host cell

  • The bacterium Vibrio cholerae exists in two forms

    • A harmless form

    • A virulent form that causes the disease cholera

      • This form is infected with a temperate bacteriophage which carries a gene encoding the cholera toxin

  • Lysogenic conversion is also responsible for the presence of toxin genes in other bacteria

    • Corynebacterium diphtheriae Diphtheria


15 9 how animal viruses enter cells

Plant viruses enter plant cells through tiny rips in their cell wall at points of injury

Animal viruses enter their host cells through endocytosis

A diverse array of viruses occur among animals

We will focus on the human immunodeficiency virus (HIV)

15.9 How Animal VirusesEnter Cells


Fig. 15.13 cell wall at points of injury

HIV

  • HIV causes Acquired Immunodeficiency Syndrome (AIDS)

  • AIDS was first reported in the US in 1981

  • Clinical symptoms of AIDS until generally 8-10 years after infection with HIV

  • During this latent period, carriers of HIV are infectious


HIV cell wall at points of injury

  • Attachment and entry

    • Virus circulates throughout the entire body but will only infect macrophages

      • Involved in the uptake and recycling of organic material

    • Specificity is mediated by gp120 protein spikes found on the HIV surface

      • gp120 binds to CD4 marker on the macrophages

      • It then binds a second receptor protein, called CCR5

        • This triggers endocytosis of the virus into the macrophage


HIV cell wall at points of injury

  • Replication

    • Once inside macrophages, HIV sheds its protective coat, releasing its RNA genome

    • The viral enzyme reverse transcriptase synthesizes double-stranded DNA from the single-stranded RNA

      • The enzyme does not proofread so many mutations are introduced

    • The double-stranded DNA is integrated into the host cell’s genome

    • In all of this, no lasting damage is done to the host cell


HIV cell wall at points of injury

  • Starting AIDS

    • Eventually, by chance, HIV alters the gene for gp120 causing it to produce a new form of gp120 protein

      • This prefers to bind to a different co-receptor, called CXCR4

    • The virus can now infect CD4+ T cells

      • New viruses exit T cells by bursting through the plasma membrane

    • The destruction of the body’s T cells causes the onset of AIDS

      • Cancers and opportunistic infections are free to invade the defenseless body


Fig. 15.14 cell wall at points of injuryHow the HIV infection cycle works


15 10 disease viruses
15.10 Disease Viruses cell wall at points of injury

  • Influenza

    • Perhaps the most lethal virus in human history

    • Natural reservoirs ducks and pigs in central Asia

  • AIDS (HIV)

    • First entered humans from chimpanzees in Africa

    • The chimpanzee virus is called simian immunodeficiency virus (SIV)

  • Ebola virus

    • Filamentous virus that attacks connective tissue

    • Natural host of the virus is unknown


15 10 disease viruses1
15.10 Disease Viruses cell wall at points of injury

  • Hantavirus

    • Discovered in 1993

    • Natural host is the deer mice

  • SARS

    • Severe acute respiratory syndrome

    • Caused by a coronavirus

      • Natural host is most likely the civet

  • West Nile Virus

    • Mosquito-borne virus

    • Natural host is birds


15 10 disease viruses2

Fig. 15.15 cell wall at points of injuryThelast known smallpox case

15.10 Disease Viruses

Ali Maow Maalin of Somalia

  • Smallpox

    • Caused by the variola virus

    • 15 million worldwide cases in 1967

    • A world immunization campaign eradicated the disease in 1977

  • The virus still exists in Atlanta and Moscow

  • “Weaponized” smallpox remains a bioterrorist threat


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