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Introduction to Cell Physiology. Slides by John R. Waters, Anatomy and Physiology at Penn State available at: www.bio.psu.edu/Courses/Fall2002/Biol141-Everything/powerpoint/All_the_intro_concepts_SummerB/. What is physiology?.

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Introduction to cell physiology
Introduction to Cell Physiology

Slides by John R. Waters, Anatomy and Physiology at Penn State

available at: www.bio.psu.edu/Courses/Fall2002/Biol141-Everything/powerpoint/All_the_intro_concepts_SummerB/


What is physiology
What is physiology?

  • The branch of biology dealing with the functions and activities of living organisms and their parts.

  • The study of bodily function that primarily employs the methods of experimental science.


Biological organization pg 17 a hierarchy of structural complexity
Biological Organization (pg.17)A hierarchy of structural complexity

  • The organism,


Biological organization pg 17 a hierarchy of structural complexity1
Biological Organization (pg.17)A hierarchy of structural complexity

  • The organism is composed of organ systems


Biological organization pg 17 a hierarchy of structural complexity2
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs,


Biological organization pg 17 a hierarchy of structural complexity3
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs, organs are composed of tissues,


Biological organization pg 17 a hierarchy of structural complexity4
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs, organs are composed of tissues, tissues are composed of cells,


Biological organization pg 17 a hierarchy of structural complexity5
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs, organs are composed of tissues, tissues are composed of cells, cells are composed partially of organelles,


Biological organization pg 17 a hierarchy of structural complexity6
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs, organs are composed of tissues, tissues are composed of cells, cells are composed partially of organelles, organelles are composed of molecules,


Biological organization pg 17 a hierarchy of structural complexity7
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs, organs are composed of tissues, tissues are composed of cells, cells are composed partially of organelles, organelles are composed of molecules, molecules are composed of atoms,


Biological organization pg 17 a hierarchy of structural complexity8
Biological Organization (pg.17) A hierarchy of structural complexity

  • The organism is composed of organ systems organs systems are composed of organs, organs are composed of tissues, tissues are composed of cells, cells are composed partially of organelles, organelles are composed of molecules, molecules are composed of atoms, and atoms are composed of subatomic particles


Chemical bonds 58 60
Chemical Bonds (58-60)

  • Atoms can be bound together to form molecules

    • 2 H+ + O--H2O (water)

    • Na+ + Cl- NaCl (sodium chloride)

    • 6 C + 12 H+ + 6 O-- C6H12O6 (carbohydrate)


Chemical bonds 58 601
Chemical Bonds (58-60)

-

O

H

H

+

  • The atoms that form molecules are bound together by chemical bonds

    • covalent bond

      • electrons shared between atoms

        • single (C-C)

        • double (C=C)

        • non-polar (C-C)

        • polar (O-H)

          • water

  • ionic bond

    • oppositely charged ions are attracted to one another

      • NaCl

  • hydrogen bond

    • weak bond between a slightly positive hydrogen and a slightly negative oxygen or nitrogen


Chemical bonds hydrogen bonds 58 60
Chemical Bonds - hydrogen bonds (58-60)

-

O

H

H

+

  • hydrogen bond

    • weak bond between a slightly positive hydrogen and a slightly negative oxygen or nitrogen


Molecules and chemical reactions 66 68
Molecules and chemical reactions (66, 68)

  • Chemical bonds between molecules can be formed or broken during chemical reactions

  • Metabolism is all of the chemical reactions occurring in your body

    • catabolism (breaking down a molecule)

      • energy released during chemical reaction

      • EX. carbohydrates are broken down to release energy

    • anabolism (synthesizing or building a molecule)

      • energy required for chemical rxn

      • EX. energy is used to build proteins or make ATP.


Molecules and chemical reactions atp 96 97
Molecules and chemical reactions – ATP (96-97)

  • ATP (adenosine triphosphate) is a molecule synthesized by organisms to store energy in a readily usable form.

  • The energy is stored in the chemical bonds of ATP molecules as chemical potential energy

    • ADP + P + energy -> ATP

  • This energy can be used by cells whenever they need to do work.

    • ATP -> ADP + P + energy



Life requires about 25 chemical elements
Life requires about 25 chemical elements

  • 96% of living matter is made up of

    • C

    • O

    • N

    • H

  • the other 4% is mostly P, S, Ca, and K

  • plus some trace elements like Fe and I


Most macromolecules are polymers 80
Most macromolecules are polymers (80)

  • Monomers are basic subunits used to build polymers(smaller molecules) (larger molecules)

    • We will focus today on two polymers

      • lipids

      • proteins




Lipids are mostly hydrophobic molecules with diverse functions (85-87)

  • Phospholipids form stable structures in water


Proteins 87 92
Proteins (87-92) functions (85-87)

H

H

H

O

H

O

N

C

C

N

C

C

H

OH

H

OH

R1

R2

  • Proteins are the molecular tools for most cellular functions

  • A protein is a polymer of amino acids connected in a specific sequence


Proteins 87 921
Proteins (87-92) functions (85-87)

H

H

H

O

H

O

+

N

C

C

N

C

C

H

OH

H

OH

R1

R2

H

O

H

H

H

O

N

C

C

N

C

C

+

HOH

H

OH

R1

R2

  • Proteins are the molecular tools for most cellular functions

  • A polypeptide is a polymer of amino acids connected in a specific sequence


Proteins 87 922
Proteins (87-92) functions (85-87)

  • Proteins are the molecular tools for most cellular functions

  • A polypeptide is a polymer of amino acids connected in a specific sequence

  • 20 different amino acids (aa)

  • Each aa has a differentR group


Proteins 87 923
Proteins (87-92) functions (85-87)

  • Proteins are the molecular tools for most cellular functions

  • A polypeptide is a polymer of amino acids connected in a specific sequence

  • 20 different amino acids (aa)

  • Each aa has a differentR group

    • Polar (+ or - charge)

  • hydrophilic


Proteins 87 924
Proteins (87-92) functions (85-87)

  • Proteins are the molecular tools for most cellular functions

  • A polypeptide is a polymer of amino acids connected in a specific sequence

  • 20 different amino acids (aa)

  • Each aa has a differentR group

    • Polar (+ or - charge)

      • hydrophilic

    • Non-polar (no charge)

  • hydrophobic

  • hydrogen, ionic, covalent bondsbetween R groups are also possible


  • Proteins 87 925
    Proteins (87-92) functions (85-87)

    • A protein’s function depends on its specific conformation

      • primary structure

      • secondary structure

      • tertiary structure

      • quaternary structure

    • Proteins are the molecular tools for most cellular functions

    • A polypeptide is a polymer of amino acids connected in a specific sequence


    Remember…. functions (85-87)

    A molecule’s biological function is related to its shape






    Review
    Review functions (85-87)


    Biochemical example of feedback control
    Biochemical Example of Feedback Control functions (85-87)

    Glycolysis: a metabolic pathway

    Negative Feedback

    Input

    (Glucose)

    Output

    (ATP)

    X

    X

    X

    X

    0

    1

    i

    n

    perturbation

    X_i : metabolites (small molecules derived from glucose)

    : chemical reactions (each catalyzed by an enzyme)


    Enzyme catalysed reactions
    Enzyme-Catalysed Reactions functions (85-87)

    http://www.uyseg.org/catalysis/principles/images/enzyme_substrate.gif


    http://www.eccentrix.com/members/chempics/Slike/Enzyme/2Competitive_inhibition.jpghttp://www.eccentrix.com/members/chempics/Slike/Enzyme/2Competitive_inhibition.jpg


    Allosteric regulation
    Allosteric Regulationhttp://www.eccentrix.com/members/chempics/Slike/Enzyme/2Competitive_inhibition.jpg

    http://courses.washington.edu/conj/protein/allosteric.gif


    A regulated enzyme phosphofructokinase pfk
    A Regulated Enzyme: Phosphofructokinase (PFK)http://www.eccentrix.com/members/chempics/Slike/Enzyme/2Competitive_inhibition.jpg

    Reactants:

    Effector:

    Product:


    How can biochemicals regulate enzyme activity by inducing conformational changes
    How can biochemicals regulate enzyme activity?http://www.eccentrix.com/members/chempics/Slike/Enzyme/2Competitive_inhibition.jpgBy inducing conformational changes


    Nucleic acids store and transmit hereditary information
    Nucleic acids store and transmit hereditary informationhttp://www.eccentrix.com/members/chempics/Slike/Enzyme/2Competitive_inhibition.jpg




    Central dogma
    Central Dogma of nucleotides


    Dna deoxyribonucleic acid
    DNA (deoxyribonucleic acid) of nucleotides

    Chain composed of bases: A, C, G, T

    http://genetics.gsk.com/graphics/dna-big.gif


    Some segments of DNA code for proteins of nucleotides

    Other segments of DNA code for RNAs (e.g. tRNAs or rRNAs.)

    http://www.designeduniverse.com/articles/Nobel_Prize/trna.jpg


    Still other segments of DNA are regulatory regions. of nucleotides

    Repression

    Activation

    http://www.emc.maricopa.edu/faculty/farabee/BIOBK/repressor_1.gif


    Basic structure of a cell 104 108
    Basic structure of a cell (104-108) of nucleotides

    • plasma membrane

    • cytoplasm

      • organelles

        • vesicles

        • mitochondria

        • nucleus

        • many others

    • proteins

      • structural

      • enzymes


    Basic structure of a cell plasma membrane 108 112
    Basic structure of a cell - plasma membrane (108-112) of nucleotides

    • lipid bilayer

    • membrane proteins

      • gates/pores

      • pumps

      • receptors

    • Plasma membranes will let some things pass, but not others

    • They are semipermeable


    Carrier mediated transport 128 131
    Carrier mediated transport (128-131) of nucleotides

    ATP

    • Requires membrane proteins

    • Two types of carrier mediated transport

      • facilitated diffusion

        • proteins channels just act as doors

        • just diffusion

        • no energy required

      • active transport

        • substances moveagainst theirconcentration gradient

        • move from an areaof low concentration...

        • to an area of high concentration

        • Requires ENERGY


    Active transport review 128 131
    Active Transport Review of nucleotides(128-131)


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