MAY HEMOGLOBIN BE A MEDIATOR OF INCREASED
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MAY HEMOGLOBIN BE A MEDIATOR OF INCREASED CARDIOVASCULAR RISK IN NAFLD?

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MAY HEMOGLOBIN BE A MEDIATOR OF INCREASED

CARDIOVASCULAR RISK IN NAFLD?

Peltec Angela1, Ivanova Victoria2, Dumbrava Vlada1 , Popovici Mihail21 Clinic of Gastroenterology and Hepatology, Department of Internal Medicine, University of Medicine and Pharmacy 'NicolaeTestemitanu', Kishinev, Republic of Moldova 2Interventional Cardiology, Institute of Cardiology, Kishinev, Republic of Moldova, [email protected]

Background:

NAFLDis associated with a significantly increased risk of adverse vascular events. Hemoglobin(Hb) concentration could affect the cardiovascular system through oxygen supply and blood viscosity.

Aim:

To investigate the association of Hb concentration with the 10-years risk of cardiovascular events in patients with NAFLD.

Methods:

A total of 117 patients (mean age: 49,66 ± 9,4 years, 63/117 - 54% females) who had NAFLD were included in the study.

The 10-years risk of cardiovascular events was calculated according to Framingham equation.

The risk score were categorized using predefined cutoffs as intermediate (≤ 20%) and high (> 20%).

Hemoglobin concentration was divided into age- and sex-dependent quintiles to evaluate the association of Hemoglobin concentration with CVD risk factors and clinical covariates including age, sex, systolic and diastolic BP, LDL and HDL cholesterol, serum triglycerides, diabetes, body mass index (BMI), smoking status, and alcohol consumption.

  • Results:

  • Participants in higher hemoglobin level quartiles (hemoglobin level more than 152 g/L) compared with the lowest quintiles (Hb less or equal than 128,5 g/L) were

  • younger(p0,001), and

  • had elevated lipids (p0,05),

  • had elevated liver enzymes (ALAT, ASAT) (p0,001),

  • not more likely to have hypertension and diabetes mellitus or had not higher BMI (p0,05)

Conclusion:

Elevated hemoglobin level (more than 152 g/L) influence cardiovascular risk profile in patient with NAFLD.

Measurement of hemoglobin level may be useful in predicting cardiovascular risk in patient with NAFLD.

  • After adjusting for known CVD risk factors, compared with the lowest quintiles (hemoglobin less than 128,5 g/L),

  • odds ratios (95% CI) were:

  • for third quintiles

  • (Hb 140 - 152 g/L): 2,07 (1,68–10,97)

  • for highest quartile

  • (Hb>152 g/L): 3,45 (1,12–10,7)

THE INTERNATIONAL LIVER CONGRESS 2013

48th ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER

AMSTERSDAM, THE NETHERLANDS, APRIL 24 - 28, 2013


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