Sponsored Links
This presentation is the property of its rightful owner.
1 / 84

第九章 原核生物基因表达的调控 PowerPoint PPT Presentation


  • 231 Views
  • Uploaded on
  • Presentation posted in: General

第九章 原核生物基因表达的调控. 基因表达调控就是对基因产物的合成进行控制的机制 . 一个细胞可能仅含有 20 个拷贝乳糖操纵子阻遏蛋白,但是它可能会需要超过 100 000 个拷贝的 EF-Tu 参与蛋白质的合成。 在另外一些情况下,单细胞有机体调控基因表达是为了应答环境条件(例如,温度,渗透压或者是否存在某种营养物质)的改变或者细胞内部的生理状况(例如为细胞分裂做准备)的变化。与细胞适应过程有关的酶或者蛋白质通常是不存在的,只有在需要的时候才被合成。 管家基因与奢侈基因.

Download Presentation

第九章 原核生物基因表达的调控

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


  • .

    • 20100 000EF-Tu


    • mRNA

    • mRNA

    • mRNA


9.1


mRNA


9.1.1

9.1.1.1


lacA


lacI




--D-IPTGIPTG


lac

catabolite repressioncatabolic activator proteinCAP


CAPcAMPCAPcAMPcAMP receptor proteinCRPcAMP-CRPRNAPlac35laccAMP-CRPRNARNARNA




  • araBADAraCaraO2araI1DNAaraBAD

  • AraCaraI1araI2AraCcAMP-CRPRNAPBAD


  • AraCaraC

  • AraCAraCAraCaraO1araPc


gal- galEgalTgalKmRNA


+ ATP 1- + ADP + H+

1- + UDPGlu UDPGal + 1-

UDPGal UDPGlu

+ ATP 1- + ADP + H+


  • P1P2

  • P2UDPGlu UDPGal

  • OEOIDNADNADNARNA

  • OEP2


(corepressor)


regulon




9.1.1.2

  • 37464630heat shock protein, HSPmolecular chaperones


  • 32703270


  • HSP32

    • 3232

    • 32



E

F


K

G



9.1.1.3


PhoRPhoB



9.1.2

9.1.2.1

trptrpRtrpRtrptrpR


trptrptrpEattenuationDNAmRNAattenuatortrp mRNA


RNA

41234



1344Utrp2233RNA1234


9.1.2.2

RNADNA



9.2

9.2.1 RNA

RNAmRNARNARNAmRNAmRNAmRNA


RNA

Fur: ferric uptake regulator

FurFurbfrbfrRNA


9.2.2

E.coli


autoregulation


9.2.3 Some mRNA molecules must be cleaved before translation

mRNAadhERNase III


9.2.3

rRNAtRNAstringent responseppGpppppGppIIIpppGpp



pppGppRNARNArRNAtRNA

relApppGpprelApppGpprRNAtRNArelArRNAtRNArelArelaxed mutant


9.3

mRNAmRNAmRNA

7B12TPP()FMN ()SAM (S)


a); b)


-6-glmSmRNAGlmS-6--6--6-GlmSGlmS mRNAmRNA


9.4 DNA

DNASalmonella typhimuriumH1H2


H1H2H2H1phase variation



site-specific recombinaseHinHinHinHinHin


  • Login