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REVIEW Questions

REVIEW Questions The slides depict phylogenetic trees with a DNA sequence chart beside them. I am very confused as to what this all means. Could we go over this? (It is in the powerpoint 'Evolution of humans and other primates", slides 6, 7 and 8).  

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REVIEW Questions

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  1. REVIEW Questions The slides depict phylogenetic trees with a DNA sequence chart beside them. I am very confused as to what this all means. Could we go over this? (It is in the powerpoint 'Evolution of humans and other primates", slides 6, 7 and 8).   What kind of adaptation/evolutionary process is it when one adaptation facilitates another adaptation ie. adaptation of bipedalism allowing the genus Homo to have free use/finer development of their hands?

  2. Hominins evolved three muscles that flex the thumb: -Flexor pollicislongus -Flexor pollicisbrevis -1st volar interosseus of Henle (80% of individuals present a pollical palmar interosseous muscle (of the thumb) as suggested by Henle's description in 1858)

  3. What is the hypothesis? “HACNS1 has undergone several instances of positive selection during human evolution that may have altered its function”. What is the prediction (Methods)? “HACNS1 and its orthologsfrom chimpanzee and rhesus macaque have to function as transcriptional enhancers during development”. “Using a transgenic mouse enhancer assay in which the activity of each sequence is assessed through a b-galactosidase (lacZ) reporter gene coupled to a minimal Hsp68 promoter”.

  4. GENE REGULATION

  5. Gain of function?

  6. Positive selection? Human-specific substitution rate at the HACNS1 locus

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