TM. 0. caBIG and caGrid: Interoperable Computing Infrastructure for the Nation’s [and World’s] Cancer Research Enterprise. Peter A. Covitz, Ph.D. Chief Operating Officer National Cancer Institute Center for Bioinformatics.
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caBIG and caGrid: Interoperable Computing Infrastructure for the Nation’s [and World’s] Cancer Research Enterprise
Peter A. Covitz, Ph.D.
Chief Operating Officer
National Cancer Institute
Center for Bioinformatics
1,372,910 new cancer cases and 570,280 deaths due to cancer expected in the U.S. in 2005
Jemal et al.,CA Cancer J Clin 2005; 55:10-30
The Cancer Biomedical Informatics Grid™ (caBIG™)
A researcher involved in a phase II clinical trial of a new targeted therapeutic for brain tumors observes that cancers derived from one specific tissue progenitor appear to be strongly affected.
The trial has been generating proteomic and microarray data. The researcher would like to identify potential biochemical and signaling pathways that might be different between this cell type and other potential progenitors in cancer, deduce whether anything similar has been observed inother clinical trials involving agents known to affect these specific pathways, and identify any studies inmodel organisms involving tissues with similar pathway activity.
ability of a system to access and use the parts or equipment of another system
caBIG Compatibility Guidelines
Model Driven Architecture + Computable Semantics =
Platform for Syntactic and Semantic Interoperability
Common Data Elements
caCORE Software Development Kit
caCORE SDK Generates a
caBIG Silver-Compliant System
Web Application Server
[Gene, Disease, etc.]
[Gene, Disease, Agent,
From Silver to Gold:caGrid
caGrid 1.0 Architecture
Quality of Service
Grid Communication Protocol
Avinash Shanbhag, NCI
Joel Saltz and colleagues, Ohio State U.
Ian Foster and colleagues, U. Chicago/Argonne
Booz Allen Hamilton