Lichenoid Dermatitides: Histologic Nuances

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Lichenoid Dermatitides: Histologic Nuances

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1. 1. Lichen Simplex Chronicus: Vertical striation of collagen surrounding the rete ridges, in the papillary dermis 2. Lichen planus: Irregular “sawtooth” hyperplasia of the epidermis with irregular thickness of the stratum granulosum and a lack of parakeratosis 3. Lupus erythematosus/Dermatomyositis: Atrophy of the epidermis with thickening of the epidermal basement membrane; LE also shows dermal mucin deposition 4. Lichen nitidus: Sharply localized lymphohistiocytic infiltrates involving the BMZ and superficial dermis, with appendageal “collarettes” surrounding them (“bear claws”) 5. Erythema multiforme: A special form of lichenoid & interface dermatitis featuring wholesale apoptosis of epidermal keratinocytes, potentially culminating in sloughing of the entire epithelial skin surface 6. Graft-versus-Host Disease: Usually subtle apoptosis Lichenoid Dermatitides: Histologic Nuances

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