Kallikreins. They originate from liver plasma kallikreinsexocrine glands glandular kallikreinsfrom the kidneyThey are responsible for the formation of kininsThey exist as prekallikreins activated by chemical and physical factors.. . . Effects of Kinins. Vascular Effects: potent vasodilatorsInflammatory effects: promote release of prostglandins, prostacyclins and histamins.Implicated in tissue reaction to injury and repair by Stimulating mitosis of T-lymphocytes and p30032
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1. Kallikrein-Kinin system They are hotmones activated by noxious stimuli to participate in tissue defense and repair.
The kinins are peptides of 9-11 amino acids generated from plasma proteins called kininogens by specific proteases called kallikreins
Kallikreins are present in plasma and organs
Produces bradykinin short- lived vasoactive peptide
Increases vascular permeability, Pain producer and potent smooth muscle dilator.
2. Kallikreins They originate from
liver plasma kallikreins
exocrine glands glandular kallikreins
from the kidney
They are responsible for the formation of kinins
They exist as prekallikreins activated by chemical and physical factors.
3. Effects of Kinins Vascular Effects: potent vasodilators
Inflammatory effects: promote release of prostglandins, prostacyclins and histamins.
Implicated in tissue reaction to injury and repair by Stimulating mitosis of T-lymphocytes and protein formation
Algogenic effect: they produce pain
Stimulate release of catecholamines from the adrenal gland.
Stimulate renin from kidneyKinins induce natriuresis and duiresis. They antagonise the effect of ADH.
7. Actions of Bradykinin Hypotensive Bradykinin is a vasoactive nonapeptide produced by the kinin system. It has a number of tissue actions:
Vasodilation, possibly by a direct effect and via prostaglandin mediation
Increase in vascular permeability by the opening of intercellular gaps in post-capillary venules
Stimulation of phospholipase A2 and production of arachidonic acid
Slow-onset, long-duration contraction of smooth muscle
8. Mechanism of Vasodilatory action of Kallikrein- kenin system