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Frank A. Bucci, Jr., MD, Bucci Laser Vision Institute Wilkes Barre, PA

Comparison of RBC Saturation with Omega- 3 Oral Supplements. Frank A. Bucci, Jr., MD, Bucci Laser Vision Institute Wilkes Barre, PA. The author of this poster is a scientific advisor for Physician Recommended Nutriceuticals . . Introduction .

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Frank A. Bucci, Jr., MD, Bucci Laser Vision Institute Wilkes Barre, PA

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  1. Comparison of RBC Saturation with Omega-3 Oral Supplements Frank A. Bucci, Jr., MD, Bucci Laser Vision Institute Wilkes Barre, PA The author of this poster is a scientific advisor for Physician Recommended Nutriceuticals.

  2. Introduction • the health benefits of dietary omega-3 fatty acids are well established, especially for dry eye and ARMD • absorption and bioavailabilty of oral supplements can vary with the type of omega-3 (pure triglyceride - TG vs. ethyl ester - EE) and formulation (mixing omegas with other ingredients)

  3. Introduction • Oral Supplements Evaluated PRN • DEOB = Physicians Recommended Nutriceuticals - Dry Eye Omega Benefit Nature Made = Nature Made - oral omega-3 supplement Thera Tears = Advanced Vision Research- Thera Tears Nutrition

  4. Purpose To compare the absorption and bioavailability (RBC saturation) of three omega-3 oral supplements using the HS-Omega-3 Index blood test®. Methods • Sixty patients • randomized to 3 groups • masked

  5. Each group received approximately 2300mg of omega-3 orally each day for 3 months Group I - PRN 2240mg omega-3 • 4 caps/day Group II - Nature Made 2400mg omega-3 • 2 caps/day Group III - Thera Tears 2332mg omega-3 • 4 caps/day Methods

  6. • Three outcomes at 3 time periods Outcomes 1. Total RBC % saturation 2. EPA % saturation of RBCs 3. DHA % saturation of RBCs Time Periods 1. Baseline 2. One month 3. Three months • % saturation was evaluated at each time period using the HS Omega-3 Index blood test Methods

  7. Results Total RBC Saturation % RBC Saturation

  8. Results EPA Saturation of RBCs % EPA Saturation

  9. Results • PRN•DEOBwas significantly greater than Nature Made for DHA at 1 month (4.42% vs. 3.72% / p = 0.23) • PRN•DEOB trended toward being significantly greater than Nature Made at 3 months (4.53% vs. 3.99% / p = 0.98) • PRN•DEOB almost reached significantly greater levels of DHA at 1 month vs. Thera Tears (p=0.62)

  10. Results (Established research has shown that a RBC saturation greater than 8% is cardioprotective) • HS Omega-3 Index exceeded 8% at 1 and 3 months PRN• DEOB (29% / 44%) Nature Made (0% / 0%) Thera Tears (0% / 0%) • HS-Omega-3 Index exceeded 7% at 1 and 3 months PRN•DEOB(59% / 75%) Nature Made (6% / 29%) Thera Tears (21% / 42%)

  11. Conclusions 1. An objective blood test, the HS Omega-3 Index revealed significantly greater total omega-3 fatty acid RBC saturation (bioavailability to target tissues) for PRN-Dry Eye Omega Benefit vs. both Nature Made and TheraTearsNutrition at 1 and 3 months after ingesting equal amounts of omega- 3

  12. Conclusions 2. Since the ingestion of EPA has been linked to less dry eye and less ARMD, it is noteworthy that this study revealed significantly greater EPA saturation of RBCs (bioavailability) for PRN • Dry Eye Omega Benefit vs. both Nature Made and Thera Tears Nutrition at 1 month and 3 months following ingestion of equal amounts of omega-3 for each product

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