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SURVEY OF BIOCHEMISTRY Glycolysis. Announcements. Exam #2 on June 26 Chapters 7, 8, 11, 12, 14 Bring calculators Study Session with Vonda Thursday, June 26; 2-3:45 pm Boggs 228. Introduction to Glycolysis. Glycolysis: breakdown of sugars Primary start point = glucose

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Presentation Transcript
announcements
Announcements
  • Exam #2 on June 26
    • Chapters 7, 8, 11, 12, 14
  • Bring calculators
  • Study Session with Vonda
    • Thursday, June 26; 2-3:45 pm
    • Boggs 228
introduction to glycolysis
Introduction to Glycolysis
  • Glycolysis: breakdown of sugars
  • Primary start point = glucose
  • 10 enzymatic reactions
overview
Overview
  • Stage I of Glycolysis
  • 2 ATP’s invested
  • 1 Glucose is brokeninto 2 phosphorylated molecules
overview1
Overview
  • Stage II of Glycolysis
  • 4 ATP’s recovered
  • 2 NADH’s produced
  • GAP is converted to pyruvate
enzymes in glycolysis stage i energy investment
Enzymes in GlycolysisStage I: Energy Investment
  • Hexokinase
    • Uses ATP
  • Phosphoglucose Isomerase [PGI]
  • Phosphofructokinase [PFK]
    • Uses ATP
  • Aldolase
    • Splits 6C into two 3C molecules
  • Triose Phosphate Isomerase [TIM]
enzymes in glycolysis stage ii energy recovery
Enzymes in GlycolysisStage II: Energy Recovery
  • Glyceraldehyde 3-Phosphate Dehydrogenase
    • Uses NAD+ to form NADH
  • Phosphoglycerate Kinase [PGK]
    • Forms ATP (2 molecules)
  • Phosphoglycerate Mutase [PGM]
  • Enolase
    • Forms high energy molecule
  • Pyruvate Kinase [PK]
    • Forms ATP (2 molecules)

Classify theseon board

key mechanisms
Key Mechanisms
  • Kinases: Transfer PO32- to substrate
  • Phosphoglucose Isomerase
  • Aldolase
  • GAP Dehydrogenase
  • Phosphoglycerate Mutase
example of kinase activity
Example of Kinase Activity

Step 1: Hexokinase

pgi reaction mechanism2
PGI Reaction Mechanism

Base catalyzes ring closure

H+

glyceraldehyde 3 phosphate dehydrogenase
Glyceraldehyde 3-Phosphate Dehydrogenase

Step 6

Remember:Glycolysis produces 2 molecules of GAP, and therefore 2 molecules of NADH

gap dehydrogenase mechanism3
GAP Dehydrogenase Mechanism

PhosphateBinding

Pi

slide24
PRS
  • What is the maximum number of O2 molecules that hemoglobin can bind?
  • One
  • Two
  • Three
  • Four
slide25
PRS
  • B cells mature in the ________.
  • Thymus
  • Bone marrow
  • Muscle tissue
  • Myosin
slide26
PRS
  • Oxygen binding to myoglobin results in what shaped curve?
  • Sigmoidal
  • Hyperbolic
  • Linear
  • Sinusoidal
slide27
PRS
  • Which of the following amino acids is not in the catalytic triad of serine proteases?
  • Ser
  • Thr
  • His
  • Asp
slide28
PRS
  • What is Km?
  • The catalytic efficiency
  • The catalytic rate constant
  • 1/2 Vmax
  • [S] at 1/2 Vmax
ad