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Can a biologist fix a radio? - or, what I learned studying apoptosis. ( Lazebnik Y. 2004)

Can a biologist fix a radio? - or, what I learned studying apoptosis. ( Lazebnik Y. 2004) . Gold (field) Rush. Stage 2: Discovery! Funding + applications  Gold rush. Stage 3: Saturation Completion/destruction of models, theory/drugs fail, confusion.

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Can a biologist fix a radio? - or, what I learned studying apoptosis. ( Lazebnik Y. 2004)

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  1. Can a biologist fix a radio? - or, what I learned studying apoptosis. (Lazebnik Y. 2004)

  2. Gold (field) Rush Stage 2: Discovery! Funding + applications  Gold rush Stage 3: Saturation Completion/destruction of models, theory/drugs fail, confusion Stage 1: Pioneering Few scientists find interest in a problem It is is difficult to find a cat in a dark room, especially if there is not cat. ~ Chinese saying The anticipated gold deposits exist, finding them is not guareteed! ~ David Papermaster

  3. Solututions Develop good tools and keep mind clear in adverse circumstances. ~ David Papermaster Stagnation is eventually interrupted by new development. ~ Joe Gall ...to getting caught in a competitive and complex field of investigation? Is the biologists approach flawed? ~ Lazebnik Test the approach in a system that has a solution. ~ Mathematicians approach

  4. A problem with a solution

  5. Begining Funding Description Classifcation Systematic mailfunctions Component Phenotype

  6. Knock-out approach MIC Most Important Component SRC Serendipitously Recovered Component RIC Really Important Component U-MIC Undoubtly Most Important Component

  7. Is the accumulated information useful? vs Intervention Tuning Sometimes (pharmacy: give me a target!) Gene therapy Atagonists Breeding Stress Nutritions Hygiene Perspective

  8. Biologist Engineer

  9. Language Massive information + standardized language = simple overview Massive information + formal language = limited overview Increased productivity More meaningful research

  10. Thank you Breen MS, Lazebnik RS, Nour SG, Lewin JS, Wilson DL. Three-dimensional comparison of interventional MR radiofrequency ablation images with tissue response. Comput Aided Surg. 2004;9(5):185-91. PMID: 16192060 [PubMed - indexed for MEDLINE]

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