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Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology

Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology. Wendy A. Suzuki Center for Neural Science New York University. MDRS Chapel Hill, NC 9/25/09. Talk Outline. Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments.

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Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology

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  1. Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology Wendy A. Suzuki Center for Neural Science New York University MDRS Chapel Hill, NC 9/25/09

  2. Talk Outline • Neuroanatomy of the PRC and area TE • Physiology of the PRC and area TE • Future experiments

  3. Ventral View of Macaque Monkey Brain TE PH PR ER rs

  4. 30-60% 18-29% 5-17% <5% TE STSv TEO STSd STG Pi 24/25/32 46 11/12 7a/LIP Ia Id 13 23/29/30 Ig V4 Parietal Lobe Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus DG HPC Sub Entorhinal Parahippocampal Perirhinal Suzuki and Amaral, 1994

  5. Cortical Inputs to the Perirhinal Cortex TE/TEO 63% STSd 6% TF/TH 25% Insula 2% Frontal lobe 2% Cingulate/Retrosplenial <1% V4 2% Perirhinal Cortex

  6. Dorsal area TE V4/TEO TF Cortical Inputs to Area TE Frontal area 8 and 45 Orbital areas 11 and 13 Perirhinal Parietal (LIPd) Area TE

  7. 30-60% 18-29% 5-17% <5% TE STSv TEO STSd STG Pi 24/25/32 46 11/12 7a/LIP Ia Id 13 23/29/30 Ig V4 Parietal Lobe Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus DG HPC Sub Entorhinal Parahippocampal Perirhinal Suzuki and Amaral, 1994

  8. What about the cytoarchitectonic features of these areas?

  9. 30-60% 18-29% 5-17% <5% TE STSv TEO STSd STG Pi 24/25/32 46 11/12 7a/LIP Ia Id 13 23/29/30 Ig V4 Parietal Lobe Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus DG HPC Sub Entorhinal Parahippocampal Perirhinal Suzuki and Amaral, 1994

  10. Talk Outline • Neuroanatomy of the PRC and area TE • Physiology of the PRC and area TE • Future experiments

  11. Pair Coding response Individual cell responses in area 36 Naya et al., 2003

  12. 50 40 30 Response (Spikes/Sec) 20 10 0 Baseline Activity -10 Behavioral Learning Curve and Delay Activity Over Time to Scene 653 1 0.8 0.6 Probability Correct 0.4 0.2 0 0 10 20 30 40 50 Wirth et al., 2003 C110600.4 Trials

  13. Bar Release Period Bar Release Period + + + + + + + + + + + + + + + + + + + + Object 1 Object 2 Place 1 Late + Early + Fixation Fixation Cue Cue Delay Delay Early Early Late Late Reward Reward ITI ITI 500ms 500ms 500ms 500ms 700ms 700ms 500ms 500ms 500ms 500ms 2000ms 2000ms + Place 2 Early + Late Object-Place Association Task Wirth et al, 2009

  14. Conclusions: Pair coding neurons are built in the perirhinal cortex from the sensory input from area TE.

  15. Talk Outline • Neuroanatomy of the PRC and area TE • Physiology of the PRC and area TE • Future experiments

  16. Experiments?

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