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Selecting the Best Evidence-Based Medicine Resources

Selecting the Best Evidence-Based Medicine Resources. Daniel J. Van Durme, MD Chairman, Dept. Family Medicine and Rural Health Nancy Clark, MEd Director of Medical Informatics Education. Objectives. What is EBM? Formulate a clinical question

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Selecting the Best Evidence-Based Medicine Resources

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  1. Selecting the Best Evidence-Based Medicine Resources Daniel J. Van Durme, MDChairman, Dept. Family Medicine and Rural Health Nancy Clark, MEd Director of Medical Informatics Education FSU College of Medicine

  2. Objectives • What is EBM? • Formulate a clinical question • Apply levels of evidence to decision making process including patient concerns • What are the major EBM databases • Search for evidence based information • Using EBM hunting tools FSU College of Medicine

  3. Handouts and Resources • EBM Tutorial onlinewww.med.fsu.edu/informatics/EBMTutorial.asp • EBM Resources handout • Clinical Question Worksheet • Cases • Slawson article on EBM FSU College of Medicine

  4. New Resource EBM Teaching Materials FSU College of Medicine

  5. What is EBM? • Evidence based medicine (EBM) was originally defined as the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients. (Sackett DL, Rosenberg WMC, Gray JAM, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn't. BMJ 1996; 312: 71-2) FSU College of Medicine

  6. What is EBM? • The revised and improved definition of evidence-based medicine is “the integration of the best research evidencewith clinical expertiseand patient values” • It reflectsa systematic approach to clinical problem solving. (Sackett DL, Strauss SE, Richardson WS, et al.Evidence-based medicine: how to practice and teach EBM. 2nd Ed. London: Churchill-Livingstone,2000)

  7. What EBM skills do all practicing clinicians really need? • Among other skills: • Information mastery: finding the best evidence for every day practice • Have at fingertips “just in time’ information at point of care for clinical decision making • web based and/or PDA • Evaluate expert-based information, including colleagues, CME, presentations, reviews and guidelines Slawson DC, Shaughnessy AF. Teaching evidence-based medicine: should we be teaching information management instead?  Acad Med. 2005 Jul;80(7):685-9.

  8. Advanced EBM Skills Only a small percentage of clinicians need to be able to do the following • Critical Appraisal and Interpretation of Research on: • Therapies, Diagnostic Tests, Prognosis • Critical Evaluation and Interpretation of: • Systematic Reviews, Including Meta-analysis, Decision Analysis, Practice Guidelines, Pharmaceutical Advertising, Including Pharmaceutical Representatives • Assigning Levels of Evidence to Research Findings • Teaching Level 1 Skills • Produce written Communication of Research Findings • Physicians • Patients                                       (Slawson, et al) FSU College of Medicine

  9. Lifelong Learning • Old method: read a few journal articles per week • Reality: Primary care docs would need over 17 hrs/day just to review reasonable and pertinent material • Even in one narrow specialty would need 6+hrs/wk • Practicing docs (all specialties) average 1-1.5 hrs/wk FSU College of Medicine

  10. Lifelong Learning from Day to Day Encounters • Reading the articles that happen to cross the desk does not help MY PATIENTS TODAY • Finding evidence based optimal care for my patients today helps them AND helps me to stay current in my field and be an efficient and effective lifelong learner FSU College of Medicine

  11. The EBM Process EBM = LLL “The practice of evidence-based medicine is a process of lifelong, self-directed, problem-based learning in which caring for one's own patients creates the need for clinically important information about diagnosis, prognosis, therapy and other clinical and health care issues.” (Bordley, D.R. Fagan M, Theige D.  Evidence-based medicine: a powerful educational tool for clerkship education. Am J Med. 1997 May;102(5):427-32.) FSU College of Medicine

  12. The EBM Process FSU College of Medicine

  13. Constructing A Clinical Question FSU College of Medicine

  14. Examples FSU College of Medicine

  15. Types of Questions Best Answered by EBM Resource • Therapy Question • In patients with migraine headaches without auras, is Depakote more effective than Inderal for prophylaxis of headaches? • Prognosis Question • In diabetic patients with foot ulcers, is the diagnosis of osteomyelitis with MRI as predictive of healing as an audible pulse on Doppler examination? • Diagnosis Question • In geriatric patients with suspected carotid stenosis, is duplex ultrasound as good as magnetic resonance angiography in detecting significant carotid stenosis? • Harm Question • For pregnant patients, does the consumption of large amounts of coffee, (compared to non-coffee drinkers) increase the rate of spontaneous abortion? FSU College of Medicine

  16. P - Who? I - What? C- Alternatively? Outcome? Type of Question Therapy Prognosis Diagnosis Harm/Etiology Question Worksheet Using the worksheet provided, construct a clinical question from your own practice. FSU College of Medicine

  17. Assessing Validity • Definitions • Level of Evidence (LOE): usually one study • Strength of Recommendation (SOR): recommendation based on multiple studies • A value of the confidence in the recommendation based on the quality of research • Assigned by experts using specific criteria Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am Fam Physician. Feb 1 2004;69(3):548-556.

  18. Levels of Evidence • Level 1: Systematic Review (with meta-analysis) of Randomized Clinical Trials • Level 2: Cohort Studies • Level 3: Case-Control Studies • Level 4: Case-series • Level 5: Expert Opinion Centre for Evidence-Based Medicine, Oxford FSU College of Medicine

  19. Strength of Recommendation Taxonomy A: There is good research-based evidence to support the recommendation. B: There is fair research-based evidence to support the recommendation. C: The recommendation is based on expert opinion and panel consensus. X: There is evidence of harm from this intervention. FSU College of Medicine

  20. Bottom Line on LOE or SOR • Level 1 A Highest level • Level 2 • Level 3 B • Level 4 • Level 5 C Lowest Level But still evidence FSU College of Medicine

  21. Evidence Based Medicine Databases (Foraging Tools) People who do the heavy lifting for you. FSU College of Medicine

  22. EBM Foraging Tools A high-quality foraging tool employs a transparent process that • Systematically searches and reviews literature • Identify useful, valuable, “quality” research • Synthesizes into “bottom line” recommendation • Patient oriented outcomes (POEM); not disease-oriented outcomes (DOE) • Assign level of evidence • How to apply recommendations? (Slawson DC, Shaughnessy AF. Teaching evidence-based medicine: should we be teaching information management instead? Acad Med. Jul 2005;80(7):685-689.)

  23. Major EBM Databases (Foraging Tools) • Cochrane • Clinical Evidence • DARE • ACP Journal Club • InfoPOEMS • Evidence Based _____ • USPSTF • National Guidelines Clearinghouse FSU College of Medicine

  24. Cochrane Library • The current resource with the highest methodological rigor • For each clinical question, all of the English literature meticulously searched for randomized trials • Large systematic reviews with valid methods + collaborative effort by Review Groups • Conclusions are based on all the evidence from valid randomized trials (treatment and harm questions) FSU College of Medicine

  25. Cochrane Library • Full text at Cochrane Library at Wiley • Abstracts in InfoRetriever • Limitations • limited to English • only addresses questions amenable to randomized trials • most of medicine has not been studied enough to allow for conclusions • $235/year or abstracts only free • www.cochrane.org FSU College of Medicine

  26. ACP Journal Club • About 140 internal medicine journals systematically surveyed • Highest-validity articles abstracted • Structured abstracts to guide critical appraisal • Clinical commentary • Web site acpjc.org • Also published in Annals of IM • Alerts available FSU College of Medicine

  27. ACP Journal Club • Limitations • Limited pediatrics • individual article summaries may not account for the “big picture” • may have to read multiple items • No “control” over what is covered • $78/year ? FSU College of Medicine

  28. InfoPOEMS POEMS • Patient Oriented Evidence that Matters • Journal of Family Practice and other specialty journals • Systematic surveillance of 100 journals • Reviews of recent research articles • Effect patient concerns – morbidity, mortality, quality of life • Included in Essential Evidence Plus (formerly InfoRetriever) • Daily e-mail updates available FSU College of Medicine

  29. Evidence Based Practice • Summaries: structured search, critical appraisal, authoritative recommendations, clinical perspective, and rigorous peer review • FPIN.org – Family Physicians Inquiries Network • Appear in PEPID FSU College of Medicine

  30. FSU College of Medicine

  31. Guidelines.gov • Stored at National Guidelines Clearinghouse • Agency for Healthcare Research and Quality • 1600 Guidelines may be • Explicit evidence-based • Evidence-based • Research-based (highly referenced) • “expert consensus” • Multiple guidelines on one condition FSU College of Medicine

  32. US Preventive Services Task Force • First convened by the U.S. Public Health Service in 1984 • Since 1998 Agency for Healthcare Research and Quality • Leading independent panel of private-sector experts in prevention and primary care • Conducts rigorous, impartial assessments of the scientific evidence for effectiveness of broad range of clinical preventive services, including screening, counseling, and preventive medications • Its recommendations considered "gold standard" for clinical preventive services FSU College of Medicine

  33. USPSTF Tool • Free PDA and online tool (ePSS) • Enter age, gender • Get recommendations • Filter level of recommendations • http://epss.ahrq.gov/PDA/ FSU College of Medicine

  34. Hunting Tools Most Bang for Your Buck FSU College of Medicine

  35. Drilling Down for Information Grandage KK, Slawson DC, Shaughnessy AF. When less is more: a practical approach to searching for evidence-based answers. J Med Libr Assoc. 2002 Jul;90(3):298-304.

  36. EBM Hunting Tools A high-quality Hunting tool employs a transparent process that • Searches multiple EBM databases (several foraging tools) • Organizes results to make them easy to find • Provides levels of evidence (Slawson, et al) FSU College of Medicine

  37. EBM Pyramid InfoRetrieverDynaMed 5, C FSU College of Medicine MEDLINE

  38. Major EBM Hunting Tools Web and PDA Summaries Summaries Summaries FSU College of Medicine

  39. Clinical Evidence • Includes >250 conditions • Summaries of evidence • Specific clinical questions: treatment and prevention • Makes specific recommendations • States when there is a lack of evidence • Book Free from United Health Foundation • Web and PDA versions available FSU College of Medicine

  40. Clinical Evidence FSU College of Medicine

  41. Do Clinical Evidence Case FSU College of Medicine

  42. Essential Evidence Plus (EE+) • POEMS -- JFP • >104 journals surveyed • Over 3500 article synopses • Link out to PubMed • Cochrane abstracts • Selected evidence-based guidelines • Basic drug info • Clinical calculators/prediction rules FSU College of Medicine

  43. New Content • Essential Evidence summaries • Organized like disease quick reference • Bottom Line at top • Links to InfoPOEMs, Cochranes • Links to calculators and algorythms, images • Uses SORT for level of evidence FSU College of Medicine

  44. EE+ Features • Essential Evidence (replaces 5MCC) • EBM Guidelines • Pearls –PDA; Favorites on Desktop • Levels of Evidence explained • ICD-9 and E/M coding tools • Immunization Guide • USPSTF Guidelines • Derm Expert FSU College of Medicine

  45. Symbols New 8/09 FSU College of Medicine

  46. Essential Evidence Plus • Comes in web, desktop and PDA versions • Daily POEMS are available in mp3 podcast version • Limitations • individual article summaries may not account for the “big picture” • may have to read multiple items • $79/year FSU College of Medicine

  47. Do EE+ Case FSU College of Medicine

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