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PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI PowerPoint PPT Presentation


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PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI. CANCER. Cancer is characterized by abnormal, unrelated cell proliferation Cancer invades healthy tissues and compete with normal cells for oxygen, nutrients, and space

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PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI

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PROLIFERAZIONE CELLULARE

E RESISTENZA AI FARMACI


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CANCER

  • Cancer is characterized by abnormal, unrelated cell proliferation

  • Cancer invades healthy tissues and compete with normal cells for oxygen, nutrients, and space

  • Abnormal cells reproduce in the same way as normal cells, but they do not have the regulatory mechanisms to control growth

  • The abnormal cell growth proliferates in an uncontrolled and unrestricted way.


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CANCER

  • Tumors are also classified according to their cell of origin and whether their growth is benign or malignant

  • BENIGN tumors remain at their site of origin

    • They may grow large, but their growth rate is slower than that of malignant tumors

    • They usually do not cause death unless their location impairs the function of a vital organ

  • MALIGNANT tumors grow rapidly are likely to undergo metastasis (See table 20-2)


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Benign vs malignant


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Epithelial cells = carcinomasConnective tissues or muscle = sarcomasHemopoietic cells = leukemiasPigments producing cells of the skin = melanoma


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6 key behaviors of cancer cells

  • They disregard the external and internal signals that regulate cell proliferation

  • They are resistant to apoptosis

  • The avoid limitations to proliferation, such as differentiation and senescence

  • They are genetically unstable

  • They are invasive (escape home tissue)

  • The metastasize (survive and proliferate in foreign tissues)


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Clonal

Evolution


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Genetic Instability and Tumor Progression


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Normal and deranged control of cell production from stem cells


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Dominant and recessive cancer genes


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Ways to make a proto-oncogene overactive


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The genetic mechanisms underlying retinoblastoma


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Rb Protein


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Major signaling pathways relevant to cancer


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p53


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Telomerase is reactivated

in Human cancers


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