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Monday, September 10, 2012. Purpose of H-W Principle:. The Hardy-Weinberg Principle provides a baseline for comparison & determines whether or not gene frequencies have changed in a population and thus whether (micro)evolution has occurred. Hardy-Weinberg Assumptions.

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Purpose of h w principle
Purpose of H-W Principle:

The Hardy-Weinberg Principle provides a baseline for comparison & determines whether or not gene frequencies have changed in a population and thus whether (micro)evolution has occurred.


Hardy weinberg assumptions
Hardy-Weinberg Assumptions

  • Very large population size

  • No migration

  • No net mutation

  • Random Mating

  • No natural selection


Hardy weinberg equations
Hardy-Weinberg Equations:

p = frequency of allele 1 in gene pool

q = frequency of allele 2 allele in gene pool

Frequencies can be expressed as decimals (0.4) or percentages (40%)

p + q = 1


Hardy weinberg equations1
Hardy-Weinberg Equations:

Allele frequency is used to predict genotype frequency (%) for a randomly mating population

Homozygous for allele 1 = p • p = p2

Homozygous for allele 2= q • q = q2

Heterozygous = p • qorq • p = 2pq

p2 + 2pq + q2 = 1


Hardy weinberg lab
Hardy-Weinberg Lab

  • Instructions dictate initial allele frequencies of:

    • p = 0.5

    • q = 0.5

  • If there are 28 Teddy Grahams in your population, how many should be pp? pq? qq?

  • Explain how you determined your answer.



Though they live a good life, it is short. After having 2 babies, they die keeping the population size constant

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Teddy graham genetics
Teddy Graham Genetics yumminess

  • Today you will be helping Teddy Grahams to procreate.

  • Reminder of the genetic rules:

    • When honey and honey mate, 2

      Honey are born

    • When honey and chocolate mate,

      2 speckled are born

    • When honey and speckled mate,

      One honey and one speckled are born

    • When chocolate and speckled mate,

      One chocolate and one speckled are born


When speckled and speckled mate
When Speckled and Speckled mate yumminess

  • Use the allele cards. Each speckled has a p and a q allele

  • Pick one allele for each parent to give

  • This determines the genes of the first offspring

  • Return the cards to the parent and pick again for the second offspring


  • Allow 5 generations to mate. yumminess

  • Fill in the data chart and calculate allele frequencies at the end of 5 generations

  • Conduct a Chi Square test to see whether the number of bears of each type you expect to have if allele frequencies did not change, differs from the observed (actual) number of each type you have


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