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IAEA Coordinated Research Project on Mo-99 Production Using LEU or Neutron Activation Progress and Status Ira N. Goldman, Natesan Ramamoorthy, Pablo Adelfang International Atomic Energy Agency 2007 RERTR International Meeting 24-27 September 2007 Prague, Czech Republic.

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Presentation Transcript
slide1

IAEA Coordinated Research Project on

Mo-99 Production Using LEU or Neutron Activation

Progress and Status

Ira N. Goldman, Natesan Ramamoorthy, Pablo Adelfang

International Atomic Energy Agency

2007 RERTR International Meeting

24-27 September 2007

Prague, Czech Republic

rertr 2007 iaea mo 99 crp
RERTR 2007IAEA Mo-99 CRP

Outline

  • History
  • Activities/Progress since RERTR 2006
  • 2nd RCM Outcome
  • Training/Technical Support and Procurements
  • Extrabudgetary Support
  • Near-Term Plans
  • Third Year Activities
  • Conclusion
rertr 2007 iaea mo 99 crp1
RERTR 2007IAEA Mo-99 CRP

History

  • February 2005 - CRP approved
  • May 2005 - Potential Mo-99 Producer’s Workshop, Buenos Aires, Argentina
  • December 2005 – 1st RCM, Vienna, Austria
  • March 2006 – Foil Targets Workshop, Serpong, Indonesia
  • November 2006 - Papers/Side Meeting, RERTR Cape Town, South Africa
  • November 2006 - Workshop on Operational Aspects of Mo-99 Production, Vienna, Austria
  • April 2007 – 2nd RCM, Bucharest and Pitesti, Romania
rertr 2007 iaea mo 99 crp2
RERTR 2007IAEA Mo-99 CRP

Progress/Activities since RERTR 2006

  • Glassware received late 2006/early 2007
  • ANSTO safety documentation distributed (early 2007).
  • IAEA participated in NAS study (Feb and June 2007).
  • Poster/paper at 17th International Symposium on Radiopharmaceutical Sciences, Aachen, April/May 2007
  • Project website increasingly important tool with Chile, Libya, MURR and other technical reports posted.
  • New Research Agreement - POLATOM.
  • New Research Contract - Egypt
  • LEU foils delivered from KAERI to Chile, Indonesia, and Romania (August 2007)
rertr 2007 iaea mo 99 crp3
RERTR 2007IAEA Mo-99 CRP

2nd RCM in Romania

  • Reviewed status/progress of CRP participants activities.
  • Reviewed domestic nuclear medicine plans and Mo-99 requirements, to determine production targets.
  • Reviewed constraints, needs, arrangements for supply/technical assistance
  • Discussed target analyses and thermal contact resistance.
  • Reviewed requirements for cGMP.
  • Conducted site visit to Pitesti and Maguerele.
  • Updated/revised work plan/action item list.
rertr 2007 iaea mo 99 crp4
RERTR 2007IAEA Mo-99 CRP

Training/Technical Assistance and Procurements

  • Libya - 5 fellowships/SVs on target preparation, processing, and waste management; laboratory equipment/supplies
  • Chile - fellowship on Mo-99 production process; procurement of telemanipulators and aluminium 3033 tubes
  • Poland - fellowship/SV on target assembly and disassembly
  • Kazakhstan & Romania (Maguerele) - SV to India re: gel generators
  • Indonesia – hot cell operations, visit to KAERI
rertr 2007 iaea mo 99 crp5
RERTR 2007IAEA Mo-99 CRP

Extrabudgetary Financial and Technical Support

  • DOE/GTRI: $205,000 – overall CRP support (contracts, meetings, procurements)
  • Libya: $100,000 - national contribution (procurements, human resources)
  • Norway: $15,000 – developing countries
  • NTI – project management
  • KAERI – NU and LEU foils
  • AREVA/CERCA – technical expertise
  • ANSTO – target safety documentation
rertr 2007 iaea mo 99 crp6
RERTR 2007IAEA Mo-99 CRP

Planned Near-Term Activities

  • Provision of foil to Libya, MURR, Poland and technical assistance for foil production to Pakistan
  • Cold assembly, testing, and disassembly (with assembled cutter) of targets (NU and LEU).
  • Prepare and cold test hot cells for processing.
  • Submit safety analysis reports to regulators.
  • Develop QA/QC procedures.
  • IAEA to continue to participate in NAS meetings.
rertr 2007 iaea mo 99 crp7
RERTR 2007IAEA Mo-99 CRP

Third Year Activities

  • Irradiation of LEU targets and processing of hot targets (early 2008).
  • Irradiation of Mo oxide and preparation of ‘moly Mo-99 gel powder for gel column generators.
  • 3rd RCM (Chile or MURR) fall 2008
  • Compare, assess, and interpret results, provide follow-up, and suggest adaptive changes.
  • Review compliance with specifications and purity requirements.
  • Make modifications to improve future efforts.
  • Document/publish results
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RERTR 2007IAEA Mo-99 CRP

Conclusion

  • Good overall progress, participants have shown commitment and creativity.
  • Substantial amount of work still required to carry out LEU target irradiation and processing.
  • Major producers supported November 2006 workshop but have been largely absent since then.
  • Appreciation to supporters (U.S. DOE, Norway, NTI, KAERI, CERCA, ANSTO).
  • Project likely to be extended beyond initial 3-year plan.
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