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CombiFlash Rf Torrent

CombiFlash Rf Torrent. For Large Scale Purification. CombiFlash Rf Torrent Capabilities. Up to 1 L/min at 100 psi 300g purifications in an hour unattended Automatic solvent level sensing Customize for different laboratory needs All external tubing for easy loading

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CombiFlash Rf Torrent

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  1. CombiFlash Rf Torrent For Large Scale Purification

  2. CombiFlash Rf Torrent Capabilities • Up to 1 L/min at 100 psi • 300g purifications in an hour unattended • Automatic solvent level sensing • Customize for different laboratory needs • All external tubing for easy loading • Collect known compounds using Time Windows • Compact design

  3. Pumping System • Level sensing on inlet and waste • Makes it a walk away large scale system • Pumps precisely from 0 to 100% • Up to 1L/min accurately • Up to 100psi consistently • Accurately delivers DCM and MeOH • Solvent can be located on the floor • Up to 100 psi • Large tubing creates minimal system backpressure • Custom inlets for variety of sources

  4. Binary Gradient • 2 Solvent inlet • B solvent auto prime for accurate gradients • 50ml/min to 1 L/min • 80 grams up to 3 kg columns purification • 80 gram useful for method development and scale up • Rapid equilibration function • Fast air purge for column disposal

  5. Customizable to Meet any Purification Need

  6. Solvent Inlet Options • Stainless steel braided* • 5 (standard), 9 ft length • Grounded flow path • Pressurized solvent reservoirs* • Custom connection • Quick Connects *Ability to have level sensing

  7. Stainless Steel Braided

  8. Remote Solvent Source

  9. Pressurized Solvent Reservoirs With Solvent Level Sensing

  10. Optional Solvent Caps • 100 mm • 83B • Available for both inlet and outlet • Customize for your container

  11. Injection Option 1 • Solid load cartridges • Cartridges available in 4 sizes • 25, 65, 260, and 750 gram • Available empty and prepacked • Prepacked with silica, Celite or C18 • Bulk silicas also available • Use cartridges as a guard column to extend the life of reusable columns

  12. Injection Option 2 • Liquid Load pump • Pull directly from a sample container • Utilize an empty cartridge as a funnel, pull from the cartridge and load onto the column • Load manually with a syringe

  13. Automatic Operation • Injection valve enables true walk-away automation • Automatically equilibrates, loads the sample and purifies • Post run - air purge, and clean the valve to ensure no cross contamination

  14. Automatic Self Cleaning Injection Valve • All external tubing • Easy to access and clean • Automatic wash sequence • Wash injection valve with strong solvent after run • Prevents buildup in valve • Automatic operation • “Start and walk away” • Rapid auto air purge

  15. Detector Options • Select from either internal UV or UV-Vis PDA detector • Peak collection via slope, threshold or time windows • Perform All-Wavelength Collection • Ability to detect small impurities in the sample • Alternatively, connect to an external detector • Teledyne Isco Model 340CF ELSD available • December software release will add Spectral Capabilities • December software release will add MS support/control

  16. Torrent Collection Option 1 • Foxy R2 High Flow Fraction Collector with RFID rack identification technology • Chain up to 4 collectors together • Collect in 16-25 mm test tubes or 450 ml bottles • Use funnel rack to collect unlimited quantities in any container • Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows

  17. RFID Test Tubes Racks • Greatest Collection Capacity – can be hot swapped • (150) 16x125 mm • (150) 16x150 mm • (140) 18x150 mm • (60) 25x150 mm • Bottle Racks – 480 ml • 480 ml bottles available • Funnel Rack (36) • RFID Rack Identification • Identifies rack sizes • Prevents overfilling or incorrect tube selection

  18. Torrent Collection Option 2 • Torrent Fraction Valve • Collect up to 6 large volume fractions and a separate waste for defined protocols • Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows • Collect a given volume per container – up to 99 L

  19. Torrent Collection Option 3 • Manual collection – no collector necessary • Collect by hand

  20. RediSep Rf and RediSep Rf Gold Columns • RFID sensors for fast setup • Run 80 gram up to 3 kg columns • Scale up from an 80 gram • Scale up from the CombiFlash Rf+ • 750g, 1.5 kg and 3 kg columns have large inlets and outlets to prevent flow restriction and crystallization • GOLD Speed and GOLD Resolution methods on RediSep Rf Gold silica columns • Save half the solvent

  21. The Real Driver to Sell a Torrent • Post Sales Revenue • At the end of 2012 there were 70 Torrents in the field • Annually each Torrent used an average of: • 750G RediSep 5 • 1500G RediSep 4 • 3000G RediSep 3 • 750G Gold 1 • 1500G Gold 2 • 3000G Gold 2 • Over $9K in columns/instrument/year Teledyne Isco Confidential

  22. Safety Features • Vapor Sensors • Pressure Sensors • Air purge for easy disposal of columns • Audible alarm when user intervention is required • Removable, washable drain tray • Static-dissipative tubing throughout • Patented level sensing ensures adequate solvent for purification and prevents waste flow • Ability to network the system, watch progress, and make run adjustments from any location through either a PC or iPad

  23. Key Markets PharmaceuticalDrug Discovery NaturalProducts AgriculturalChemistry Foodsand Flavors Petrochemicals Teledyne Isco Confidential

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