Long term effects of dietary intake
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Long term effects of dietary intake. Dr Lorraine Brennan School of Agriculture, Food Science & Veterinary Medicine UCD, Belfield, Dublin 4, Ireland. Overview. Relationship between dietary patterns and metabolomic profiles Quick overview of some items for discussion.

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Long term effects of dietary intake

Dr Lorraine Brennan

School of Agriculture, Food Science & Veterinary Medicine

UCD, Belfield, Dublin 4, Ireland


Overview

  • Relationship between dietary patterns and metabolomic profiles

  • Quick overview of some items for discussion


Relationship between dietary intake patterns and metabolomic profiles.


Study Design

Dublin Cork

n=160

85 females 75 males

3- day weighed food diaries


33 Food Groups

Cluster

1

Cluster

2

Cluster

3

Dietary Pattern Analysis

WISP

K-means Cluster Analysis


A O’ Sullivan, 2010 In Preparation


Reflection of dietary clusters in NMR profiles

A O’ Sullivan, 2010 In Prep


Biomarker of vegetable intake

//

p<0.000

A O’ Sullivan, 2010 In prep


Reflection of dietary clusters in fatty acid profiles

† Indicates significant difference between males and females

A O’ Sullivan, 2010 In Prep


Principal component analysis: regional differences

Plasma

Fatty Acids

Urinary

Metabolites

Cordoba

INSERM

Oslo

Uppsala

Reading

Maastricht

Trinity


8

7

6

5

1

4

3

t[2]

2

t[2]

1

0

0

-1

-2

-3

-1

-4

-1

0

1

-5

t[1]

-6

-5

-4

-3

-2

-1

0

1

2

3

4

5

t[1]

European regions

Urinary

Metabolites

R2X = 0.318

Q2 = 0.370

Plasma

Fatty Acids

R2X = 0.690

Q2 = 0.643

Northwest

Southwest

Northeast


Conclusion

  • 3 dietary patterns indentified

  • Dietary patterns were reflected in the NMR urine profiles

  • Dietary patterns were reflected in plasma fatty acid profiles

  • Consequences and need for run-in diets


Phenotyping

Hypothesis: identification of metabotypes: lead to the identification of dietary responsive phenotypes


Overview of discussion session

  • Topics for discussion

    • Effects of acute dietary intake

    • Effects of chronic dietary intake

    • Run-in diets

    • Biomarkers of dietary intake

    • Phenotype

    • Interplay between genotype and the metabolome

    • Identification of metabotypes: role in nutrition


Study Design

Dublin Corkn=160

85 females 75 males

Data collected in 2 phases, Spring and Autumn

4 weeks

Dietary Intervention

Restricted Diet

Restricted Diet


Phenotyping of subjects

14 biochemical parameters

k-means cluster analysis

Identification of 5 distinct phenotypes

3

4

2

1

5


Phenotyping of subjects

A O’ Sullivan, 2010 Submitted


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