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Antipsychotics. How they work C. Matthews MSN, RN, CNE Fall 2013. Understanding theory on cause of schizophrenia helps understand meds that work for management of psychoses. Symptoms. “positive” +++++. Negative -------. Normal with normal behaviors/thoughts SUBTRACTED

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Antipsychotics

Antipsychotics

How they work

C. Matthews MSN, RN, CNE

Fall 2013


Understanding theory on cause of schizophrenia helps understand meds that work for management of psychoses


Symptoms
Symptoms understand meds that work for management of psychoses

“positive” +++++

Negative -------

Normal with normal behaviors/thoughts SUBTRACTED

MINUS includes lack of interest, motivation, responsiveness, or pleasure in everyday activities

  • Normal PLUS abnormal symptoms

  • PLUS hallucinations, delusions, disorganized thoughts or speech patter


Positive negative symptoms come from different areas of the brain
Positive & Negative symptoms come from different areas of the brain

  • Video explaining how antipsychotics work

  • http://www.ask.com/youtube?q=how%20antipsychotic%20drugs%20work

  • The screen goes blank – right click to end power point and the you tube site will show up on your computer, go to you tube video with this picture…….

  • I’d stop at 11min 8 sec.


Things the rn should know about antipsychotics
Things the RN should know about Antipsychotics the brain

  • Autonomic effects (see anticholinergic poster in classroom – “can’t see, can’t pee, can’t spit, can’t poop”):

  • blurred vision; urinary retention; Dry mouth; Constipation

  • These can be minimalized by intervention:

    • Laxatives, mouth care, candies or meds for dry mouth

  • May disappear with long-term continued therapy.


  • Things the rn should know about antipsychotics1
    Things the RN should know about Antipsychotics the brain

    • Extrapyramidal symptoms:

      • Dystonias

      • Tardive dyskinesia:

        • “rhythmic involuntary movements of facial muscles”

    EPS


    EPS the brain

    • http://www.bing.com/videos/search?q=youtube+tardive+dyskinesia+symptoms&FORM=VIRE7#view=detail&mid=1D9F56AFEF0C824CC9341D9F56AFEF0C824CC934

    • Not everyone has such extreme movements.

    • These are same movements seen in Parkinson’s disease (you’ve seen Michael J. Fox). They are caused by same thing – a disturbance in the balance of the neurotransmitters dopamine and acetylcholine in the basal ganglia.


    References
    References the brain

    • Adams, M. , Holland, N. & Urban, C. (2014). Pharmacology for nurses, a pathophysiologic approach. (4th Ed.) Pearson, Boston.

    • Adams, M. P. & Urban, C.Q. (2013). Pharmacology connections to nursing practice. (2nd ed.) Pearson, Boston.