Iron deficiency
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Iron deficiency. Anemia :-. Deficiency in number of redblood cells or deficiency in total hemoglobin content per unit of blood volum. Anemia can be caused by :-. 1- Excessive blood loss. 2 – Blood destruction caused by :- i- drug therapy. ii- Infection and toxines.

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Iron deficiency

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Iron deficiency

Iron deficiency


Deficiency in number of redblood cells or deficiency in total hemoglobin content per unit of blood volum .

Anemia can be caused by :-

1- Excessive blood loss .

2 – Blood destruction caused by :-i-drug therapy.

ii- Infection and toxines .

iii- Defective hemoglobin( thalassemias) .

Iron deficiency

3 – Decreased bloodformation can be caused by:-

i-deficiencies of key materials such as :-

folic acid, iron , pyridoxin ( VB6)coblamin (VB12),

ii- Renal insufficiency .

iii - Bon marrow failiar .

iv – Infections.

Anemia treatment : -

1- Blood transfution.

2 – Using the deficient materials necessary for red blood cells formation.

3 – Treatment the pathological condition causing the anemia.

4 – Supplemental therapy .

Iron deficiency anemia in infants

Iron – deficiency Anemia in Infants :-

Infant iron stores exhausted due to : -

1- Very low iron intake in first few months. 2-Highironneeds requird for rapid growrh.

Infant iron stores is about 250 mg . This value is fond even if the mother is iron deficient.

This iron store preventsanemia during the first few months.

Infants need about 0.9 mg iron daily.

Iron replacement supplemental therapy

Iron replacement & supplemental therapy

Drugs used for this purpose : -

1-Must be biologically available compounds.

2- Non irritating compounds.

When iron replacement and supplemental therapy prescribed these points must be taken : -

1- The oral rout is the best of choice .

2-Ferrous salts are better absorbed than ferric salts, but thy have the same side effects .

Ferrous sulphat FeSO4 is the standerd drug used.

Iron deficiency

Iron is protein precipetant and can be irritant to the G.I. tract, so it is usually given after meals.

Iron is bestly absorbed in between meals in the duodenum.

Official Iron Products


: 1-Ferrous fumarate







M.wt. 169.9

Iron deficiency

It is red-orang to red-brown oderless powder.

Slightly soluble in water.

Very lowsoluble in alcohol.

It is resistant to oxidation on air exposure

Little conversion to ferric form.

Dissolved in dil. HCl producing fumaric acid.

FeC2H2(CO2) + 2HCl FeCl2 + C2H2(CO2H)2

Dose : 200 mg tablet( equal to 60 mg iron )

1-3 times daily

USP name : ircon , toleron .

2 ferrous gluconate


2-Ferrous gluconate



M.wt. 482.18



Yello-green powder with oder like burnt sugar.




Its solution(1/20conc.) is acidic to litmus.

Soluble in water but insoluble in alcohol.

It has goodbioavailability.

Dosage : 300 mg ,3 times / day ( equiv. To 35 mg iron

N.F. Name :Fergon

3 ferrous sulphate feso 4 m wt 278

3-Ferroussulphate : FeSO4 ( M.wt.278.)

Blue- green oderless crystals or granules .

It has saline test and efflorescent in dry air .

Oxidized in moist air producing ferric sulphate

Fe4 [ (OH)2(SO4)5]

Its sol.(1/10 con. ) is acidic to litmus .

It can be irritating for G.I. mucosa due to astringent action of the soluble ion .

Ferrous sulphate is the drug of choice .

Dose : 300 mg tablets( equiv. 60 mg iron ) 2-3 times

Syrup,every 1000cc, sucrose825gm,as stabilizing agent and2.1gm citric acid as an acid buffer .

4 iron dextran injection usp imferon

4-Iron Dextran injection(USP imferon)

FerrichydroxideFe(OH)2 complexed with dextrane(glucose polymer of low M.wt.)

Its solution has PH 5.2-6.5 for intramuscular injection .

Used in sever iron deficiency where oral drugs are not effective

The dose must be carefullymeasured according to tables .

Dose : 100 mg iron equivalent

5 iron sorbitol injection usp jectofer

5-Ironsorbitol injection ( USP : Jectofer)

Acomplex of iron, sorbitol and cetric acid stabilized with dextrin and sorbitol .

Brown clear liquid PH 7.2-7.9 for intramuscular injection ,100-200 mg daily

Non – official preparatios : -

1-Dextriferron ( Astrafer ) : -

Aquous sol. of ferric chloride complexed with dextrin , used for I.V. injection only .

Iron deficiency

Immidiate reactions of dextriferron : -

Flushing of face,nausea,headache,vomitting abdominal pain, hypertention,collapse and severe anaphylactoid responses.

Delayed effects : fever,chills. And sensation of stiffness in arms and legs . Dose 20-30 mg/daily.

2-Ferro cholinate : -

Ferric iron chelated preparation for pediatric use. Used as drop, liquid and tablets .

Other preperations include : ferric ammonium citrate.

Ferric cacodylate,FeCl3, Fe2O3,FeCO3, etc.

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