Telomeres and Telomerase in Cancer. By Tara Lynn. What is a telomere?. A telomere is the end structure of a chromosome. Telomeres are essential regulators of both cell life span and chromosomal integrity. . [email protected], University of Texas, Southwestern Medical Center .
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By Tara Lynn
Telomerase Demo created by Dr. Donald F. Slish at SUNY, Plattsburgh
Telomeres in embryonic cells, germ cells, and cells that require extended regenerations are long.
All other cells have short telomeres.
With each cell division telomeres become shorter, until after dozens of divisions telomeres get lost and the cell eventually dies. (Bodnar et al. (1998) Science 279, 349-352).
[email protected], University of Texas, Southwestern Medical Center
Telomere Loss Telomerase Activation