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Computerized Physician Order Entry: a focus on medication prescription. Nicolette de Keizer & Saeid Eslami Dept Medical Informatics University of Amsterdam. Outline. Definition and context Advantages of CPOE Disadvantages of CPOE Outcome measures and examples Same system other outcome.

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Computerized physician order entry a focus on medication prescription l.jpg

Computerized Physician Order Entry: a focus on medication prescription

Nicolette de Keizer & Saeid Eslami

Dept Medical Informatics

University of Amsterdam


Outline l.jpg
Outline prescription

  • Definition and context

  • Advantages of CPOE

  • Disadvantages of CPOE

  • Outcome measures and examples

  • Same system other outcome


What is computerized physician order entry cpoe l.jpg
What is Computerized Physician Order Entry (CPOE)? prescription

Ordering of tests, medications, and treatments for patient care using computers

Involves electronic communication of the orders

Often use rules-based methods for checking appropriateness of care


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CPOE, EHR and DSS prescription

Documentation

DSS

Medication

EHR

Test reports (EKG, PFT)

Radiology, lab results

CPOE


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CPOE prescription

  • Has a positive influence on patients’ outcome

  • Has a negative influence on patients’ outcome


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CPOE Advantages prescription

Automate ordering process

Reduces Order Errors

Standardized, legible complete orders

DSS/Alerts

Data collected on variances in practice


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Case Example prescription

Metformin is prescribed to a patient with an elevated creatinine level.

A drug-lab interaction alert warns that use of this medication could result in an increased risk of fatal lactic acidosis.


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Case Example prescription

A physician prescribes warfarin for a patient with chronic atrial fibrillation.

System:

vitamin K rich food likely to interfere with the efficacy of the drug.

Specific patient information


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Example DSS in CPOE – medication prescription prescription

  • Allergy

  • Age (check drug name and dose)

  • Duplicate drugs on active orders, not one-time

  • Severe drug interactions

    • Drug-drug, drug-food

  • Dose maximum

  • Drugs with opposite actions


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CPOE Disadvantages prescription

Errors still possible

Alerts

Multiple steps

Access



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CPOE prescription

  • Has a positive influence on patients’ outcome

  • Has a negative influence on patients’ outcome

  • On which outcome measure?


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Outcome measures prescription

  • Adherence to guideline

  • Alerts - user response

  • Time

  • Safety

    • Medication errors

    • ADEs (mortality)

  • Cost and Efficiency

    • Medication costs

    • Pharmacists interventions

  • Satisfaction, usage and usability


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Example CPOE improves adherence to guideline prescription

Teich JM et al. Arch Intern Med. 2000 Oct 9;160(18):2713-4.


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Example CPOE reduce errors prescription

  • Potts studied ADE rates in 13,828 medication orders before/after CPOE implementation at Vanderbilt Children’s PICU:

Potts AL, Barr FE, et al. Pediatrics. 2004 Jan;113(1 Pt 1):59-63.


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Example CPOE prescriptionintroduces errors

  • Brigham and Womens' Hospital, Boston introduced a CPOE

  • After implementation, the rate of intercepted Adverse Drug Events (ADE) doubled!

  • Reason: The system allowed to easily order much too large dosages of potassium chloride without clear indicating that it be given in divided doses.

  • Bates et al The impact of computerized physician order entry on medication error prevention. JAMIA 1999, 6(4), 313-21.


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Example CPOE prescriptionintroduces errors

Association with increased PICU mortality:

2.8% 14 months before CPOE

6.4% 5 months after CPOE

Han YY, Carcillo JA, et al. Pediatrics. 2005 Dec;116(6):1506-12.


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Example CPOE reduce costs prescription

Brigham and Women’s Experience: Cost-Effective

  • Cost:

    • $3.7 million implementation

    • $ 600,000 to $1.1 million operational costs

  • Results:

    • Decreased drug costs

    • ADE cost is approximately $4,700

  • Kausal R et al. J Am Med Inform Assoc. 2006; 13(3): 365-7


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CPOE and cost prescription

  • Huge variation in actual costs based on hospital size and complexity of system

    • Hardware and Software: $1-$5 million

    • Staff training

    • Ongoing maintenance

    • Total costs for large, fully integrated systems could be up to $60 million

  • Costs will decrease when DSS is geared to cost reduction


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Usability Problems prescription

Potential selection errors

Similar medication names

Similar patient names

Overly trust default values

Influence workflow and communication

Physician resistance

Frequent data entry required

Must not require additional time

Most decision-support steps must be turned off to encourage use

“Not-invented-here” syndrome


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CPOE as a Sociotechnical intervention prescription

  • Health information systems has to deal with the actors, the artefacts, and their interaction.

CPOE =socio-technical systems


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Same system other outcome prescription

  • Upperman vs. Han

    • same hospital: Pittsburgh Childrens Hospital

    • other outcome measure: ADE vs mortality

  • Han vs. Del Beccaro

    • Same CPOE

    • Different hospitals

    • Same outcome measure (mortality)

Upperman et al. J Pediar Surg. 2005;40:57–59; Han et al. Pediatrics. 2005 Dec;116(6):1506-12; Del Beccaro. Pediatrics 2006;118;290-295.


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Upperman et al prescription

* p<0.05


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Han et al prescription

* p<0.05


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Del Becarro et al prescription

  • Same results for:

  • transported patients

  • congenital cardiovascular disease patients


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Upperman vs Han prescription

  • Surrogate outcome measures such as medication errors and ADEs are not sufficient

  • More studies on mortality are necessary


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Han vs. Del Beccaro prescription

  • Methodological differences:

    • Han used unbalanced before after periods

    • Del Beccaro did not correct for case mix differences in before vs after period

    • Populations Han vs. Del Beccaro were not comparable


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Han vs. Del Beccaro prescription

  • Pittsburgh implemented too fast without pilot and usability testing:

    • Order entry only allowed when patient physically entered hospital

    • All medication in central pharmacy

    • Pharmacy processed order only after complete activation by nurse

    • Go live without necessary order sets


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Han vs. Del Beccaro prescription

  • Seattle hospital learned from Pittsburgh

  • Factors influencing successful implementation:

    • response time and user time

    • meeting information needs (e.g.using order sets)

    • multidimensional integration with workflow

    • Involvement leaders, support staff, clinicians

    • training

    • improvement through evaluation and learning


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Will a CPOE improve quality of care? prescription

Yes if you implement it the right way!!


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Successful CPOE implementation prescription

  • Technical Infrastructure:

    • EHR

    • Drug information database

    • DSS

  • Sociotechnical implementation strategy

    • Usability pilots

    • Teams of informaticians, physicians, nurses, clerks, therapists

    • Strong leader and good project management

    • Training and support

  • R. Gardner: “implementation is 90% organizational and political and 10% technical”


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