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Supplementary Figure 1

A B. 1 00 80 60 40 20 0. 1 00 80 60 40 20 0. isotype parental DR4 overexpression. isotype parental DR5 overexpression. events. events. 0 10 2 10 3 10 4 10 5 DR4-Alx647. 0 10 2 10 3 10 4 10 5 DR5-Alx647.

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Supplementary Figure 1

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  1. A B 100 80 60 40 20 0 100 80 60 40 20 0 isotype parental DR4 overexpression isotype parental DR5 overexpression events events 0 102 103 104 105 DR4-Alx647 0 102 103 104 105 DR5-Alx647 50 25 0 NS NS NS specificapoptosis (%) TRAIL  + + + ­ parental DR4 overexpression DR5 overexpression SupplementaryFigure 1

  2. A * * * * * * 50 25 0 specificapoptosis (%) parental p53 p53p53p53p53p53 wt V143A R175H R248W R249S R273H p53-FKBP p53 GAPDH SupplementaryFigure 2

  3. B * * * * * 50 25 0 * specificapoptosis (%) parental p53 p53p53p53p53p53 wt V143A R175H R248W R249S R273H SupplementaryFigure 2

  4. CEM A * 100 75 50 25 0 specificapoptosis (%) mock shp53 p53 GAPDH SupplementaryFigure 3

  5. B 25 0 SKW6 REH specificapoptosis (%) mock shp53 25 0 p53 NS NS 50 25 0 NS NS GAPDH 25 0 SW48 Nalm6 specificapoptosis (%) specificapoptosis (%) specificapoptosis (%) mock shp53 p53 p53+/+ p53-/- mock shp53 GAPDH p53 p53 SupplementaryFigure 3 GAPDH GAPDH

  6. C * * * 100 75 50 25 0 A549 JURKAT 50 25 0 specificapoptosis (%) specificapoptosis (%) 50 25 0 H1299 mock shp53 mock shp53 p53 p53 GAPDH GAPDH specificapoptosis (%) p53-/- p53 wt p53-FKBP GAPDH SupplementaryFigure 3

  7. 0 -25 -50 -75 -100 Relative reductionof p53 expression in p53 siRNAtransfectedcells (%) ALL-10S ALL-54 ALL-177 SupplementaryFigure 4

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