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On line (DNA and amino acid) S equence Information

On line (DNA and amino acid) S equence Information . Lecture 9. Introduction. Basic bioinformatics Databases NCBI home page Query and return results DNA sequence results page Protein sequence results page . Bioinformatics Database.

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On line (DNA and amino acid) S equence Information

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  1. On line (DNA and amino acid) Sequence Information Lecture 9

  2. Introduction • Basic bioinformatics Databases • NCBI home page • Query and return results • DNA sequence results page • Protein sequence results page

  3. Bioinformatics Database • Bioinformatic Databases contain information forvarious biological data: • Consider the following [NCBI] query: • What is the DNA and amino acid sequence for the following protein: • homo sapiens[organism] AND elastase[title] AND leukocyte[title]

  4. NCBI : Entrez (main page)

  5. The nucleotide results returned

  6. The linear DNA option:5292 bp

  7. B.P. and AA sequence Note p08246 [protein code] and Base 1287 [highlighted in blue] is start codon ATG

  8. Fasta file for protein (p08246)

  9. Graphic file for protein (p08246) CDD: conserved domains; disulphide bonds between to cystine AA is important in the protein folding process: 1’ to 2’ to 3 ‘

  10. Main bioinformatics databases • DNA (nucleic acid) sequences: • NCBI(usa){ leukocyte elastase gene}, Graph format • EMBl (europe) { leukocyte elastase gene}, • Genome Databases: Ensemble elastase record • UniProt protein sequences: Elastase record • More information in the January issue of • Nucleic Acid Research (open access)

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