Center for Integrative Chemical Biology and Drug Discovery presents:

Aug 14, 2014

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Center for Integrative Chemical Biology and Drug Discovery presents:. A Chemical Biology Symposium Wednesday, June 9, 2010 8:30am – 12:00pm Bioinformatics Auditorium 1131. Lunch sponsored by Promega Corporation www.promega.com.

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Center for Integrative Chemical Biology and Drug Discovery presents:

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Center for Integrative Chemical Biology and Drug Discovery presents: A Chemical Biology Symposium Wednesday, June 9, 2010 8:30am – 12:00pm Bioinformatics Auditorium 1131 Lunch sponsored by Promega Corporation www.promega.com

“Drug discovery engines”

“Drug discovery engines”. Using membrane receptor microarrays to streamline the initial stages of drug discovery. The present-day drug discovery process is slow and painful. Potential targets are identified Large number of potential drug candidates are synthesized, and target binding assessed

613 views • 33 slides

Drug Design / drug discovery

Drug Design / drug discovery. Jerome Baudry Assistant Professor BCMB UT/ORNL Center for Molecular Biophysics. 2 previous incarnations: Research faculty at UIUC Research scientist at Transtech Pharma, Inc. . Drug Design / drug discovery. What’s a drug?

912 views • 26 slides

Ligand-based drug discovery

Ligand-based drug discovery. No a priori knowledge of the receptor What information can we get from a few active compounds. Drug-likeness: what makes a drug a drug?. Lipinski’s “rule of 5”: most drugs have less than two violation of the following rules: * ≤ 10 hydrogen bond acceptors

353 views • 14 slides

Computer-aided Drug Discovery G.P.S. Raghava

Annotation of genomes Searching drug targets Properties of drug molecules Protein-chemical interaction Prediction of drug-like molecules. Computer-aided Drug Discovery G.P.S. Raghava. Drug Informatics. * Bioinformatics Centre * IMTECH Chandigarh.

367 views • 12 slides

Bioinformatics The big picture

Bioinformatics The big picture. Knowledge discovery and Problem solving Molecular data Drug discovery Research on cancer and other diseases Clinical data Improvements in medical care. Molecular Biology in the context of Bioinformatics . Within The Central Dogma Gene discovery

430 views • 24 slides

Drug Development Evaluation

. Objectives:By the end of this lecture all students should know:- Major terminologies related to drug discovery, development and evaluation- Stages of drug development- Phases of clinical drug trials. . Definitions:DrugAny chemical that can affect living processes= virtually all chemicals m

525 views • 27 slides

Computer-aided Vaccine and Drug Discovery G.P.S. Raghava , Scientist and Head Bioinformatics Centre Institute of Microb

Understanding immune system Breaking complex problem Adaptive immunity Innate Immunity Vaccine delivery system ADMET of peptides . Annotation of genomes Searching drug targets Properties of drug molecules Protein-chemical interaction Prediction of drug-like molecules.

434 views • 25 slides

Herb-drug interactions

Herb-drug interactions. Charlotte Gyllenhaal, Ph.D. 1,3 Gail Mahady, Ph.D. 2 Departments of Medicinal Chemistry and Pharmacognosy, 1 Pharmacy Practice 2 Block Center for Integrative Cancer Treatment 3 6-1870, gyllenha@uic.edu. Outline. Evidence for herb-drug interactions

758 views • 38 slides

Growth of Epigenetics Technology Market by 2017

Over the last decade, genomics and proteomics have been used as key tools to discover potential drug targets and to better understand the complexities of biology. To balance research in these areas, epigenetics offers a potential opportunity in understanding the basis of various diseases in a different approach. Thus, epigenetics is study of heritable changes in genome function and gene expression had opened the new gate of biology to understand the basis of diseases and presents incredible opportunities for disease diagnosis and drug discovery.

221 views • 6 slides

Natural product drug discovery limitations when compared to synthetic chemical drug discovery :

Natural product drug discovery limitations when compared to synthetic chemical drug discovery : 1- Building up and maintaining a high-quality natural product library requires a skill set that is not generally available in industry.

780 views • 16 slides

ChEMBL – Open Access Database For Drug Discovery

ChEMBL – Open Access Database For Drug Discovery. By – Udghosh Singh M.S.( Pharm ), 3 rd Sem Pharmacoinformatics. Those who cannot remember the past are condemned to repeat it. Things you would not like to see in our hits Specifically: reactive/labile chemical groups

477 views • 26 slides

Introduction to the Chemical Biology Program

Introduction to the Chemical Biology Program. Chulabhorn Graduate Institute June 5 th , 2012. Chemical Biology. Emphasizes the interface between Chemistry and Biology, as well as its potential applications for other fields

386 views • 16 slides

How and Why Novartis is Exploiting GRID Technology?

How and Why Novartis is Exploiting GRID Technology?. HPC and Semantic Web Prof. Manuel C. Peitsch, PhD Global Head of Systems Biology. The Challenges of Drug Discovery. Mechanism-based Drug Discovery Understanding Disease Pathways elucidation Target validation Clinical PoC

458 views • 35 slides

Herb-drug interactions

722 views • 33 slides

Automation for Genomics Discovery at the Oklahoma Genome Center

Automation for Genomics Discovery at the Oklahoma Genome Center. Bruce A. Roe Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019. Working Innovation into the Drug Discovery Pipeline June 3, 2004 Houston Marriott Medical Center.

749 views • 63 slides

Structural biology and drug design: An overview

Structural biology and drug design: An overview. Olivier Taboureau Assitant professor Chemoinformatics group-CBS-DTU otab@cbs.dtu.dk. Drug discovery. Drug and drug design.

852 views • 44 slides

Modern Methods in Drug Discovery

Modern Methods in Drug Discovery. Aims of this course: comprehensive knowledge about all processes in the drug discovery pipeline in particular in silico methods of drug design. flow of information in a drug discovery pipeline. bioinformatics. Covered by this lecture.

649 views • 47 slides

Integrative Cancer Biology

Integrative Cancer Biology. Tomas Radivoyevitch, PhD Assistant Professor Epidemiology and Biostatistics Case Western Reserve University Email: radivot@hal.cwru.edu Website: http://epbi-radivot.cwru.edu/. Times are Changing.

271 views • 14 slides

David Mann 1 & Caroline Low 2 1 Molecular Cell Biology 2 Drug Discovery Centre

Cdc25 and cancer: molecular modelling approaches for identification of a chemical start point for drug discovery. David Mann 1 & Caroline Low 2 1 Molecular Cell Biology 2 Drug Discovery Centre. Cdc25 Phosphatases. Inactive Cdk. T. Cdk. Cyc. Cyc. Y. P. P. P. P. ADP. 60% identical

491 views • 34 slides

Symposium: Academic Drug Discovery: Challenges and perspectives

Calcium dependent protein kinases and Malaria: Identification of chemical start point for drug discovery. Oliver Billker & Katie Chapman. Symposium: Academic Drug Discovery: Challenges and perspectives Imperial College London, March 2011. Antimalarial drugs. Artemisinin. C hloroquine.

338 views • 19 slides

AS Biology

AS Biology. Module 1 Section 1.3 DNA Technology. Specification. Polymerase Chain Reaction (PCR). The most important discovery in biology since the discovery of the structure of DNA!

552 views • 37 slides

Druggable Genome and Proteome

“the most fruitful basis for the discovery of a new drug is to start with an old drug” (James W Black, Nobel de Medicina 1988). Druggable Genome and Proteome. Karen A. Méndez L. Druggability. Thomas H Keller, et al. Current Opinion in Chemical Biology 2006, 10:357–361.

517 views • 11 slides

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Center for Integrative Chemical Biology and Drug Discovery presents:

Center for Integrative Chemical Biology and Drug Discovery presents:

Presentation Transcript

“Drug discovery engines”

Drug Design / drug discovery

Ligand-based drug discovery

Computer-aided Drug Discovery G.P.S. Raghava

Bioinformatics The big picture

Drug Development Evaluation

Computer-aided Vaccine and Drug Discovery G.P.S. Raghava , Scientist and Head Bioinformatics Centre Institute of Microb

Herb-drug interactions

Growth of Epigenetics Technology Market by 2017

Natural product drug discovery limitations when compared to synthetic chemical drug discovery :

ChEMBL – Open Access Database For Drug Discovery

Introduction to the Chemical Biology Program

How and Why Novartis is Exploiting GRID Technology?

Herb-drug interactions

Automation for Genomics Discovery at the Oklahoma Genome Center

Structural biology and drug design: An overview

Modern Methods in Drug Discovery

Integrative Cancer Biology

David Mann 1 &amp; Caroline Low 2 1 Molecular Cell Biology 2 Drug Discovery Centre

Symposium: Academic Drug Discovery: Challenges and perspectives

AS Biology

Druggable Genome and Proteome

David Mann 1 & Caroline Low 2 1 Molecular Cell Biology 2 Drug Discovery Centre