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NCBI: something old, something new

NCBI: something old, something new. What is NCBI?. On November 4, 1988 that President Ronald Reagan signed the Health Omnibus Extension Act to create The National Center for Biotechnology Information as part of National Library of Medicine at NIH.

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NCBI: something old, something new

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  1. NCBI: something old, something new

  2. What is NCBI? On November 4, 1988 that President Ronald Reagan signed the Health Omnibus Extension Act to create The National Center for Biotechnology Information as part of National Library of Medicine at NIH. • Create automated systems for knowledge about molecular biology, biochemistry, and genetics. • Perform research into advanced methods of analyzing and interpreting molecular biology data. • Enable biotechnology researchers and medical care personnel to use the systems and methods developed.

  3. The National Center for Biotechnology Information (NCBI) Bethesda,MD • Part of • National Library of Medicine (NLM) at • National Institutes of Health (NIH)

  4. NCBI: down on the farm • Genome assembly and annotation • Pre-computed relationships for: • Protein clusters • “Nearby” nucleic acid • EST unigene clusters • Putative homologous genes • Conserved protein domains • SNPs • Reciprocal links

  5. NCBI Daily Users Web page views: 26 million per day Web users: 2.7 million per day Data downloaded: 23 TB per day Peak web hits: 7,000 per second

  6. NCBI: Integrated platform for data analysis and visualization Primary Data sets: BioProject, BioSample, Genome, Assembly, Annotation Curated data sets: Refseq genomes, Gene, Protein Clusters, Pathogenic Factors, Targeted Loci Entrez search and retrieval system Analysis Tools: Annotation pipeline, genome alignments, protein clustering, multiple alignments, (assembly, SNP) Validation Tools: assembly and annotation quality assesment Visualization Tools: genomeMap, distance tree, proteinMap, Genome Comparison

  7. How to navigate through NCBI resources Text search in Entrez Search in MapViewer All databases Marker/gene name Specialized databases Accession # Use limits page Organism name Sequence search Pre-computed similarities BLAST Blink Genome BLAST CDD Splign/ProSplignTaxPlot Use Genome specific resources

  8. Getting Started: NCBI Home Page http://www.ncbi.nlm.nih.gov Search resources by name Search All Databases in Entrez Learn more: Newsletter Education mailing lists

  9. NCBI Resources by name

  10. How to: NCBI help pages

  11. The NCBI Handbook

  12. Keeping up with what’s new NCBI News on Bookshelf www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=newsncbi

  13. Genetic Testing Registry (GTR)

  14. BLAST

  15. Entrez Assembly

  16. Entrez Genome redesign

  17. Microbial Genome Resources

  18. NCBI on Facebookand Twitter

  19. David Lipman on GenBank 25th Anniversary

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