Case presentation l.jpg
This presentation is the property of its rightful owner.
Sponsored Links
1 / 25

Case Presentation PowerPoint PPT Presentation


  • 98 Views
  • Uploaded on
  • Presentation posted in: General

Case Presentation.

Download Presentation

Case Presentation

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Case presentation l.jpg

Case Presentation

A 45 year old man presents to the office in the afternoon for a routine physical exam. The exam is normal except for being slightly overweight (BMI 28). All his lab studies are normal except for a random blood glucose of 190 mg/dL. You call him and he relates that he had a Snickers bar and a glass of milk about 2 hours earlier. He returns for a fasting blood glucose in a few days and it is 100 mg/dL. Repeat FBG is 98 mg/dL. Hemoglobin A1C is 6.7% (normal range, 3.8-6.5%).


Ada dm criteria using fbg 2003 l.jpg

DIABETES MELLITUS

IMPAIRED FASTING GLUCOSE

NORMAL

FBG*

 126 ( or 2-hr PG  200; or random BG  200 + symptoms)

100-125

<100

ADA DM Criteria using FBG (2003)

(* Diagnosis of DM or IFG needs confirmation on another day)


Slide3 l.jpg

DM

IGT

NORMAL

FBG (mg/dL)2-hr PG (mg/dL)

126 OR 200

<126 AND 140-199

<126 AND<140

1998 WHO Criteria for DM and Impaired Glucose Tolerance using FBG and 2-hr PG (Diabetes Med 15: 539, 1998)

IGT, impaired glucose tolerance; PG, postprandial glucose

(Diagnosis of DM or IGT needs confirmation on another day)


Glucose intolerance l.jpg

Glucose intolerance

Normal  Impaired glucose tolerance  Type 2 diabetes

T i m e


Igt and cv outcomes l.jpg

IGT and CV outcomes

  • IGT but not FPG predicted later CV disease in Japan (1999, Diabetes Care)

  • 2-hr PG but not FPG predicted mortality in DECODE study (1999, Lancet)

  • 2-hr PG predicted CV outcomes better than FPG in Framingham study (2002, Diabetes Care)

  • 2-hr PG had greater predictive value for coronary events and overall CV mortality than FPG in Finland (2002, Euro Heart J)

    Conclusion: Postprandial glucose, reflecting glucose intolerance, is more predictive of CV risk and mortality than FPG.


Igt and risk of vascular disease l.jpg

Macrovascular

coronary disease, etc.

Microvascular

retinopathy, nephropathy

Marked increased risk

No increased risk

IGT and Risk of Vascular Disease


Glucose ingestion absorption l.jpg

Glucose Ingestion/Absorption

  • Dietary intake of complex or simple carbs- mono-, di-, or polysaccharides

  • Rapid transit from mouth through esophagus to stomach

  • Gastric emptying, regulated by duodenal osmoreceptors and inhibitory GI hormones and peptides

  • Intestinal digestion to monosaccharides by amylases and intestinal disaccharidases

  • Rapid intestinal glucose uptake (sodium-coupled)

  • Entry into portal blood with delivery to liver (first) and then peripheral blood (glucose “excursions”)

  • Disposal of glucose (rapid=glucose tolerance; slow=glucose intolerance)


Some ways to blunt glucose excursions into blood l.jpg

Some Ways to Blunt Glucose Excursions into Blood

  • Reduce total caloric intake per day and per meal

  • Reduce % of calories as carbs (low carb)

  • Eat/drink slower

  • Slow gastric emptying (  in early type 2 DM)

  • Increase fiber composition of the diet

  • Block enzymatic digestion of complex carbohydrate to monosaccharide

    • acarbose (PrecoseR) or meglitol (GlysetR)


Stop niddm trial using acarbose chiasson et al jama 290 486 494 2003 l.jpg

STOP-NIDDM Trial Using Acarbose Chiasson et al. JAMA 290: 486-494, 2003

  • 1429 patients from 9 countries with IGT

    • Men and women equally represented; ave. BMI = 30.9

  • Randomized to placebo or acarbose, 100 gm tid with meals


Slide10 l.jpg

GLUCOSE

placebo

acarbose

meal

snack


Slide11 l.jpg

MAJOR CV EVENTS


Slide12 l.jpg

HYPERTENSION


History of incretins l.jpg

History of Incretins

  • Concept proposed in 1906 by Moore; secretin proposed as gut hormone that enhanced postprandial insulin release

  • Term incretin introduced 1932 by LaBerre

  • Berson and Yalow developed RIA for insulin in 1960s, after which several groups found plasma insulin levels were higher after PO than IV glucose when BG was the same

  • Term entero-insular axis coined by Unger (1969)

  • GIP isolated by Brown in 1969 (Gastric Inhibitory Peptide)

  • GLP-1 (7-36) discovered in 1988 (Göke)

  • Term incretins (glucoincretins, insulinotrophic hormones) today refer to hormones/peptides that reduce glucose excursions into blood after a meal via various mechanisms


Gip as an incretin l.jpg

GIP as an incretin

  • Glucose-dependent Insulin-releasing Peptide

  • 42 aa peptide; t ½ 7-8 min

  • Made in intestinal K cells

  • Released by carbs and fat

  • GIP-RA GIP7-30 reduces postprandial insulin in rats (pro-diabetic)

  • GIP-R gene deletion leads to glucose intolerance and impaired insulin secretion in mice


Glp 1 as an incretin l.jpg

GLP-1 as an incretin

  • Glucagon-Like Peptide-1

  • 30 aa peptide; t ½ 1-2 min

  • Made in intestinal L cells by action of proconvertase 1 and 3 on proglucagon

  • Released by carbohydrates

  • GLP1-RA exendin 9-39 amide reduces postprandial insulin secretion in humans (pro-diabetic)

  • GLP-1 gene deletion leads to glucose intolerance and impaired insulin secretion in mice

PC2

PC1/3

PC, proconvertase


Physiology of the incretin glp 1 l.jpg

Physiology of the incretin, GLP-1

  • Rapid release from ileal L cells within 15 minutes of eating (neural / ? GRP)

  • Releases insulin if BG is >70- 90 mg/dL via GLP-1R, adenylate cyclase, cAMP, PKA

    • Therefore little risk of hypoglycemia with GLP-1 Rx

  • Increases insulin gene transcription, leads to β cell proliferation, and  β cell apoptosis

  • Rapid metabolism in blood by dipeptidyl peptidase IV (DPPIV), or CD26 to inactive fragment GLP-13-30


Slide17 l.jpg

Plasma insulin(pM)

Plasma glucose(mM)

Glu + GLP-1

IV glucose

( or saline)

GLP-1

( or saline)

GLP-RA


Slide18 l.jpg

Oral glucose (9 normals)

Oral glucose

Plasma GLP-1

Plasma glucose

(mM)

(pM)

+ GLP-RA

- GLP-RA

GLP-1 RA

or saline


Effects of glp 1 and gip on glucose metabolism l.jpg

GLP-1

 insulin (incretin)

? insulinomimetic

 islet/ cell mass

 glucagon secretion and hepatic gluconeo-genesis

 gastric emptying

GIP

 insulin (incretin)

insulinomimetic

 islet/ cell mass

 glucagon secretion but  gluconeogenetic response to glucagon

 gastric emptying

Effects of GLP-1 and GIP on Glucose Metabolism


Glp 1 glucagon and satiety l.jpg

GLUCAGON

GLP-1  glucagon sec’n

Indirect, via  insulin and somatostatin

Direct, via GLP-1R on α cell

High I/G ratio ’s hepatic glucose production

Possible role in type 2 DM

 serum glucagon in type 2

 glucose suppression of glucagon release in type 2 DM

SATIETY/GASTRIC EMPTYING

GLP-1 infusion results in early satiety

GLP-1Rs exist in the hypothalamus (satiety center)

GLP-1 slows gastric emptying (ileal “brake”) which can contribute to satiety

GLP-1, Glucagon, and Satiety


Slide21 l.jpg

NORMAL GLUCOSE TOLERANCE

Oral Carbs

digestion

absorption

+

+

GLP-1

GIP

 cell

Insulin release  Glucose clearance (low excursions)


Slide22 l.jpg

TYPE 2 DIABETES MELLITUS

Oral Carbs

GLP-1*

GIP

 cell

*  GLP-1 not

seen in IGT; thus,

prob. is due to DM

 Insulin release  Glucose intolerance (high excursions)


Antidiabetogenic role of glp 1 l.jpg

Antidiabetogenic role of GLP-1

  • Glucose analog 1,5-anhydro-D-fructose enhances endogenous GLP-1 release (no trials in humans as yet; animal studies promising)

  • Continuous subcutaneous infusion of GLP-1 for 6 weeks  FPG 80 mg% and hemoglobin A1Cby 1.3% in type 2 DM

  • GLP-1 receptor agonist peptides that are resistant to DPPIV:

    • NN2211 (lyraglutide), sq once/day  FPG from 146 to 124 mg/dL

    • Exendin-4 (from venom of Gila monster, with 50% homology to GLP-1) subcut. bid  A1C from 9.1 to 8.3% after 1 month

  • Inhibition of DPPIV by oral NVP DPP728:

    •  FPG and PP-BG by around 1 mmol/L (18 mg/dL) in mild type 2 DM on no oral agents after 4 weeks, with  in A1C from 7.4% to 6.9% and minimal side effects so far


Conclusions l.jpg

Conclusions

  • Glucose intolerance better predicts macrovascular disease outcomes than does fasting glucose

  • Glucose tolerance can be improved with -glucosidase inhibition, with reduced macrovascular complications and primary prevention of hypertension

  • Glucose intolerance may in part be due to reduced incretin release and/or action (GLP-1, GIP, others)

  • GLP-1 agonists or inhibitors of GLP-1 degradation may benefit patients with type 2 (or type 1) DM

  • Other incretins such as GIP may also be of benefit


  • Login