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TLR7/9

IL-10. A. B. Chronic virus stimulation. TLR7/9. ?. SMC/ fibroblast. B cell. Myeloid APC. PDC. +. IFN- a , IL-6 TNF- a , IL-10. CMV. CMV. CMV. CMV. CMV. CMV. CMV. CMV. +. IL-6, TNF- a RANTES,MIF MIP-1 a , MIP-1 b. cox-2 5-LO. CD4 + T cell. +. Viral mimicry.

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TLR7/9

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  1. IL-10 A B Chronic virus stimulation TLR7/9 ? SMC/ fibroblast B cell Myeloid APC PDC + IFN-a, IL-6 TNF-a, IL-10 CMV CMV CMV CMV CMV CMV CMV CMV + IL-6, TNF-a RANTES,MIF MIP-1a, MIP-1b cox-2 5-LO CD4+ T cell + Viral mimicry Generation of CD4+CD28null T cells PGE2, LTB4 Humoral autoimmune phenomena Th1 cytokines granzyme Amplification of inflammation C D ? VCAM-1 E-selectin SMC Endothelial cell - - - Platelet adhesion/ aggregation US28 PDGF IL-1b, IL-8, fractalkine Myeloid APCs T cells Inhibition of APC maturation, cytokine secretion and cell migration Inhibition of T cell proliferation/ responses Inhibition of APC differentiation Thrombosis SMC migration and proliferation - Inflammation, leukocyte recruitment and adhesion Inhibition of myelopoiesis Increased angiogenesis Inhibition of NK activity Immunosuppression Vascular damage and vessel narrowing

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