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The Varying Permeability Model By Dan Reinders. An easy explanation for the mathematically disinclined. First an Introduction to bubbles:. The pressure of gas in a bubble is equal to the surrounding hydrostatic pressure plus a contribution from surface tension.

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the varying permeability model by dan reinders

The Varying Permeability ModelBy Dan Reinders

An easy explanation for the

mathematically disinclined

first an introduction to bubbles
First an Introduction to bubbles:
  • The pressure of gas in a bubble is equal to the surrounding hydrostatic pressure plus a contribution from surface tension.
  • The contribution from surface tension is found by the following formula: P(surface tension) = 2/radius
  • A bubble about the size of a red blood cell (4 um radius) has its pressure raised by up to 0.5 atmospheres.
gas diffuses from bubbles
Gas diffuses from bubbles
  • If the pressure inside a bubble is greater than the pressure of the DISSOLVED gas in the surrounding tissue, the bubble will shrink.
  • Conversely if the pressure in the bubble is less than the tissue dissolved gas pressure the bubble will grow.
slide4
Except for after decompression, this means that all bubbles should eventually dissolve - surface tension makes the bubble pressure higher than the surrounding dissolved gas pressure.
  • This is especially true for divers, since the dissolved gas pressure is lower than the ambient pressure due to oxygen metabolism.
  • In reality, bubbles don’t always dissolve.
enter the varying permeability model
Enter the Varying Permeability Model!
  • To explain why bubbles don’t always dissolve, a lot of ideas have been suggested.
  • The best explanation so far is that the tiny bubbles become stabilised by “surface active molecules”
  • These are molecules that embed themselves in the gas-water interface.
how do surfactants stabilise bubbles
How do “surfactants” stabilise bubbles?
  • Just as each water molecule “pulls” towards each-other in surface tension, each surface active molecule “pushes” against the others.
  • This counteracts the effect of surface tension, and therefore eliminates the loss of gas by diffusion.
  • No diffusion means no bubble dissolution.
surfactants can be thought of as tiny springs pushing against each other at the interface
Surfactants can be thought of as tiny springs pushing against each-other at the interface.
what happens during crushing
What happens during crushing?
  • When a bubble is compressed by descending, the area available for each spring lowers. Basically each spring pushes back more as it bumps against it’s neighbours.
  • But just like real springs, eventually it can’t push back any more - it runs out of travel.
  • At this point springs will start popping off the bubble surface.
slide9
More precisely, it becomes energetically favorable for a spring to leave the surface rather than to compress further.
  • The effect of surface tension is now countered and the bubble stabilises at its new smaller radius.
growing bubbles
Growing Bubbles
  • Recall that bubbles grow when the dissolved gas pressure is greater than the interior bubble pressure.
  • This means that small bubbles require a greater “super-saturation” in order to be stimulated into growth.
  • Therefore crushed nuclei are better for divers than uncrushed nuclei.
wait a second didn t you just say that the surface tension was negated in the crushed nuclei
Wait a second - didn’t you just say that the surface tension was negated in the crushed nuclei?
  • This would mean that big bubbles would grow as easily as small bubbles.
  • But this doesn’t happen.
  • At first the bubble expands, but then the springs “lose contact” with each-other.
  • Then they can’t push against each-other and surface tension reigns supreme.
do surfactant s have any other effects
Do surfactant’s have any other effects?
  • Yes - they form a barrier to diffusion.
  • The closer they are squeezed together, the stronger the barrier to diffusion.
kunkle vs yount
Kunkle vs. Yount
  • There are two main bubble surfactant models out there:
  • One by Dr. Thomas Kunkle
  • One by Dr. Yount
kunkle s model
Kunkle’s model
  • Assumes that when surfactants leave the bubble they don’t return or interact in any way.
  • Fully accounts for the “springiness” of the springs.
  • The diffusion barrier strength depends on the space available for each surfactant.
yount s model
Yount’s Model
  • Assumes that there is a reservoir of surfactants “hanging around” just outside the bubble.
  • Accounts for the transfer of surfactant molecules between the reservoir and the bubble surface.
  • Uses “unspringy springs”, the springs either don’t push back or else push back at their “popping-off” threshold. They act more like billiard balls than springs.
what s the deal with varying permeability
What’s the deal with “Varying Permeability”?
  • The surfactants either don’t form a diffusion barrier, or completely block diffusion.
  • This “impermeability” occurs after about 300 fsw of compression, so is not really a concern for most divers.
  • An impermeable bubble won’t be crushed as much as a permeable bubble because gas doesn’t diffuse out as it shrinks.
the reservoir
The Reservoir
  • The VPM also accounts for an electrostatic force between the reservoir and the surface.
the electrostatic forces
The Electrostatic Forces
  • “B” is the sum of various electrical and chemical attractions and repulsions.
  • The pressure balance equation is: Pbubble + 2c/radius - B = Ambient Pressure + 2/radius
  • c accounts for the springy “push back” effect of the surfactants.
what we need to know about bubble crushing
What we need to know about bubble crushing.
  • We assume that the gas pressure in the bubble is equal to the outside tissue pressure - aka diffusive equilibrium.
  • Ignoring oxygen effects, this means that Pbubble is equal to the ambient pressure since the ambient pressure would equal the tissue pressure.
slide20
Using the pressure equation: before crushing: Ptis + 2c/ro - B0 = Psurface+ 2/ro after crushing: Ptis + 2c/rcrush - Bc=Pdepth+ 2/rcrush
  • Where Ptis is the tissue gas pressure (assumed equal to Psurface), ro is the initial radius and r crush is the final radius.
  • Setting B0 equal to Bc gives us the equation for the crushed radius
the crushing formula
The CRUSHING formula:

Pcrush = Pdepth - Ptis

CF = Crush factor = 2 (c - )

Rcrush = 1/((Pcrush/CF) + 1/ro)

the meta stable state
The Meta-Stable state
  • A different “B” value is used as the tissue saturates, to represent the nuclei forming a semi-stable state.
  • The nuclei is exponentially restored to it’s original size as surfactants return from the reservoir to the interface.
  • This process occurs over many days, but may occur faster in living organisms.
decompression and nuclei
Decompression and Nuclei
  • Even a bubble not stimulated to growth will expand with a drop in pressure.
  • The same equations are used: During saturation: Ptis + 2c/rs - Bs = Pdepth+ 2/rs after decompression: Ptis + 2c/rd - Bd=Psurface+ 2/rd
  • d subscript refers to decompression, s refers to saturation
bubble growth
Bubble Growth
  • Bubbles grow when the super-saturation pressure is greater than 2/r (surface tension).
  • Note that nuclei growth during decompression makes the nuclei easier to turn into a full-fledged bubble.
  • All of the previous equations can be combined to find the smallest bubble stimulated into growth.
bubble numbers
Bubble Numbers:
  • The VPM predicts that there is an exponential distribution of nuclei - lots of small ones and a few big ones.
  • The number of nuclei stimulated into growth is related to the minimum size stimulated into growth by the following equation:
  • Nstimulated = Ntotal (e - K * Rstimulated )
take home messages
Take Home Messages
  • Greater super-saturation stimulates more bubbles into growth
  • Greater crushing pressures help minimise the number of stimulated bubbles
  • Saturation decompressions must be more conservative to allow for the loss of the crushing effects.
vpm and dive tables
VPM and dive tables
  • There is a lot of confusion about how the VPM is integrated in dive models.
  • The concept is actually quite simple, but this simplicity is somewhat hidden by the elegant procedures used to generate the dive tables.
minimum bubble number
Minimum Bubble Number
  • The VPM assumes that there is a minimum bubble number (regardless of bubble size) that can be tolerated without decompression sickness.
  • IF this is true, then keeping the super-saturation\'s below that required to stimulate the critical number of nuclei should prevent decompression sickness.
slide29
This assumption works great for saturation exposures, but is too conservative for normal (no-deco/mild deco) dives.
  • Solution - assume that there is a maximum volume of gas that is allowed, ONLY counting nuclei from below a critical radius
half times and bubble growth
Half-times and bubble growth
  • “Fast tissues” remove inert gas faster than slow tissues, meaning that bubbles don’t have time to grow as big as they do in slow tissues.
  • Initially the bubbles grow faster because of the typically higher pressure difference, but this is greatly outweighed by the quick removal of source gas.
many small or few big
Many small or few big
  • This means fast tissues can have lots of small bubbles, while slow tissues can have hardly any bubbles above the minimum number.
  • A Greater super-saturation is allowed for fast tissues.
increasing gradients
Increasing Gradients
  • The VPM starts out by just stimulating the minimum safe number of bubbles.
  • The maximum allowed super-saturation is then increased, and the volume of excess gas in each compartment is compared to the maximum permitted.
  • If it is less than allowed, the super-saturation is increased again and again, until the compartment maximum is reached.
does the vpm apply
Does the VPM apply?
  • It certainly has shown that it can be used to generate successful dive tables.
  • It has some support from human and animal data.
  • It has apparently been successful during data fitting by Dr. Wienke with the new Reduced Gradient Bubble Model.
other candidate models
Other candidate models
  • Many of the successes of the VPM (deeper predicted decompression stops, etc) can also be explained by models of diffusive bubble growth and “phase equilibrium” models (where there is an excess of available nuclei for the gas to grow into bubbles).
  • Impossible at present to tell which model is correct, so best to reserve judgement.
other ways to stabilise nuclei
Other ways to stabilise nuclei
  • Hydrophobic crevices can also form nuclei (you see this in your beer glass).
  • Nuclei may also be continually created by friction in your joints and muscles and by cavitation in your heart valves. The magnitude of these effects may turn out to be more important than crushing and regeneration effects.
bottom line
Bottom line
  • Both phase equilibrium, diffusive bubble growth and VPM models have been used to successfully generate dive tables.
  • All of these models make suggestions of the same nature (deeper stops and lower super-saturation’s), so we don’t really have a way to discriminate amongst them.
conclusion
Conclusion
  • VPM recommendations make sense from a variety of perspectives.
  • Surfactant stabilised micronuclei may or may not prove to be a key player in human decompression sickness, but regardless the pioneering work of Kunkle and Yount has greatly broadened our understanding of how bubbles form - their contribution should not be underestimated.
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