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How are synaptic vesicles clustered?

How are synaptic vesicles clustered?. Daniel Gitler, Department of Physiology and Cell biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev. Presynaptic terminal. Postsynaptic terminal. Gitler et al., J Neurosci 2004.

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How are synaptic vesicles clustered?

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  1. How are synaptic vesicles clustered? Daniel Gitler, Department of Physiology and Cell biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev

  2. Presynaptic terminal Postsynaptic terminal Gitler et al., J Neurosci 2004

  3. Vesicles redistribute into the axon when synapsins are ablated 500 nm Orenbuch et al., J Neurosci 2012

  4. Darcy at al. 2006 Measuring vesicle mobility Orenbuch et al., J Neurosci 2012

  5. Model for vesicle clustering

  6. Synapsins are ATP binding proteins Crystalographic structure of ATP bound to the central domain of synapsin I Do mutations in ATP binding sites affect clustering and mobilization of vesicles? Esser et al., 1998

  7. Other topics • Does mobilization of reserve vesicles require endocytosis? • The basis for epilepsy in the synapsin TKO mice and in cases of human familial epilepsy linked to synapsin • The possibility of a functional interaction between synapsin and alpha-synuclein, a protein involved in Parkinsons disease

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