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Thomas Mc Avoy Kate Malinowski University of Maryland, College Park, MD Warren D. D’Souza

Modeling and Control of a Radiation Therapy Couch (Counteract Breathing Induced Tumor Motion) in honor of Tom Edgar’s 65 th Birthday. Thomas Mc Avoy Kate Malinowski University of Maryland, College Park, MD Warren D. D’Souza Muhammad Yousuf

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Thomas Mc Avoy Kate Malinowski University of Maryland, College Park, MD Warren D. D’Souza

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  1. Modeling and Control of a Radiation Therapy Couch(Counteract Breathing Induced Tumor Motion)in honor of Tom Edgar’s 65th Birthday Thomas Mc Avoy Kate Malinowski University of Maryland, College Park, MD Warren D. D’Souza Muhammad Yousuf University of Maryland School of Medicine, Baltimore, MD

  2. 1993 Alaksa Trip

  3. Tom Edgar’s Record of Accomplishments ● Supervised 45 MS and 80 PhD’s • ● Over 250 Research Papers • ● Numerous Professional Awards (Allan P. Colburn, Warren K. Lewis , Eckman Education , …) • ● President of AIChE and AACC • ● UT Austin Department Chair, Associate Dean , Vice President for Computing Serious Obstacles Tom Overcame

  4. Cancer & Radiation Therapy

  5. Breathing Induced Tumor Motion • Examples: • ● Lung Tumors (Leading cause of cancer death) • ● Tumors Close to • Diagphragm

  6. Existing Tumor Motion Correction Methods • Planning Margin to avoid geometrical misses • Results in increased volume of normal tissue irradiated • Breath-holds (voluntary and forced) • Not tolerated well by lung tumor patients • Increased treatment time • Gating • Requires patients to breathe reproducibly • Increased treatment time

  7. Gating Window

  8. Breathing Induced Tumor Motion • University of Maryland solution: • Reposition the treatment couch (and the patient) in real time to compensate for tumor motion

  9. Inferential Model and Treatment Couch Control System respiration disturbance controller couch Set pt = 0. couch position tumor position (not measured) + - + - + inferential model estimated tumor position + + estimated tumor position relative to couch measured external marker positions relative to couch

  10. PLS Inferential Model External Markers: Partial Least Squares Regression x 0.2 Tumor: x 1.5 + x 0.1

  11. Feedback Control System Performance with Simulated Couch Dynamics Raw tumor motion Residual motion t=0.068 s, c=0.10 s, t = 0.067 s

  12. Recent Progress: Hardware System

  13. Real-Time Motion Synchronized Treatment Couch (Interesting Process Control Problem) • Received Funding From NIH • Prototype Couch Has Been Constructed • Inferential Data Base Being Developed • Dynamic Modeling/Control Being Studied

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