Immune System. Objectives To select genes that are embryonic lethal Or accept bone marrow from other centres Generate bone marrow chimeras Or generate conditional mutants for EUCOMM allels Analyse phenotypes of these mutants and Establish the course of embryonic lethality.
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Analysis of a B cell phenotype for an embryonic lethal mutation (polymerase beta)
Analysis of a complex phenotype for an embryonic lethal mutation using conditional gene targeting (gp130)