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Maintaining the ocular surface of the eye: the role of corneal epithelial stem cells in health and disease. Mary Ann Stepp, Ph. D. Professor Department of Anatomy and Cell Biology and of Ophthalmology. How are the corneal epithelial stem cells maintained

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Maintaining the ocular surface of the eye the role of

Maintaining the ocular surface of the eye: the role of

corneal epithelial stem cells in health and disease

Mary Ann Stepp, Ph. D.

Professor

Department of Anatomy and Cell Biologyand of Ophthalmology


Maintaining the ocular surface of the eye the role of

How are the corneal epithelial stem cells maintained

throughout our lifetime within their niche at the limbus

despite all the insults the ocular surface is forced to endure?


Maintaining the ocular surface of the eye the role of

Some problems that can arise on the ocular surface…

Recurrent

Erosion

Corneal Epithelial

Stem Cell Deficiency

(CESCD)

After PRK


Maintaining the ocular surface of the eye the role of

Some problems that can arise on the ocular surface…

Recurrent

Erosion

Corneal Epithelial

Stem Cell Deficiency

(CESCD)

After PRK

Development of mouse model for the study

of these conditions


Maintaining the ocular surface of the eye the role of

4 integrin whole mount

The cornea is optically well

suited for microscopic analysis


Maintaining the ocular surface of the eye the role of

4 integrin whole mount

The cornea is optically well

suited for microscopic analysis


Maintaining the ocular surface of the eye the role of

To get at the mechanism of these affects, we have a cell culture model we are using to study cell adhesion and migration.


Maintaining the ocular surface of the eye the role of

To get at the mechanism of these affects, we have a cell culture model we are using to study cell adhesion and migration.


Maintaining the ocular surface of the eye the role of

To get at the mechanism of these affects, we have a cell culture model we are using to study cell adhesion and migration.


Maintaining the ocular surface of the eye the role of

Many important questions remain but we believe we have a

model system that continues to give us new insight into the how cell adhesion regulates the stem cell niche.

THANK YOU FOR YOUR ATTENTION!


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