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?? ?? ?? ???. ? ?: ? ? (??????)? ? ?: ? ? ? ? 10 ? ??????? . ?? ?? ??? ??? ??. 1. ?? ???? Basis2. ??? ?? ??3. ??? ?? ? ?? ??? ????. ?? ?? ??? ??? ??. 4.??, ??? ??? ?? ??. ? ???(???), ???(??? ?) ??5.???? ??, ?? ?? ??? ??? ?? ?? ? ex) ?

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1. ??????? (?????) ????? ??? ??? ? ? ? ?: ? ? ?

2. ?? ?? ?? ??? ? ?: ? ? (??????) ? ? ?: ? ? ? ? 10 ? ???????

3. ?? ?? ??? ??? ?? 1. ?? ???? Basis 2. ??? ?? ?? 3. ??? ?? ? ?? ??? ????

4. ?? ?? ??? ??? ?? 4.??, ??? ??? ?? ??. ? ???(???), ???(??? ?) ?? 5.???? ??, ?? ?? ??? ??? ?? ?? ? ex) ??, ???.

5. ? 11? ????? 1. ?? ?? 2. ??? ??? ?? 3. ? ?? 4. ???? ??? ?? ?ex) ????? ?? ??, ?? ? ?? ????

6. ? 11? ????? 5. ????, ?? ?? 6. ???? ?? 7. ?? ? ?, ? ??. ??, ??, ?? ??

7. ? 11? ????? 1.????? ????? 2.??? 3.??? ?? 4.?? ?? 5.???? ??(function)

8. ? 11? ????? 6. ??? ? ???? 7. ? ?? 8. ? ? 9. ??? ? ? ?????? 10. ?? ??

9. ? 2 ? ?????? ?? ?? 1.????? ????? ??? ????? ??? ?? ?? ?????? 1. ????? ??, ???? ?? 2. ??? ??? ??, ????. 3. ?? ????

10. ? 2 ? ?????? ?? ?? 1)????? ?? ? ?? ?? ?? 2)? ?? ? ? ?? ?? ?? 3)??? ?? ?? ?? 4)??? ?? ?? ?? 5)?? ? ??? ?? ??

11. ? 2 ? ?????? ?? ?? ?? : ???? ???? ?? ???? ??? ?? ?. ??? ??? ???? ???? ???? ???? ???? ?? ?? ??? ? ??? ?? ??

12. What is Stroke? Stroke is a type of cardiovascular disease. It affects the arteries leading to and within the brain. When that happens, part of the brain cannot get the blood (and oxygen) it needs, so it starts to die.

13. What is Stroke? A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked by a clot or bursts. ?Ceribral embolism or thrombosis ? ??? ? ?????

14. Ischemic Stroke The most common type of stroke is caused by a clot or other blockage within an artery leading to the brain. ? Ceribral infarction ? ?????

15. ? 2 ? ?????? ?? ?? 3. ??? ?? ?????(Hemorheology): ??? ? ????? ??? ?? ?? ?? ???? ?? ?????? ?? ??? ? ??

16. ? 2 ? ?????? ?? ?? 3. ??? ?? ???? 1) ?? ?? 2) ??? ?? (= Hematocrit HCT) 3) ??? ???(ESR) 4) ??? ?? ?? 5) ??? ??? ??

17. ? 2 ? ?????? ?? ?? 4. ?? ?? ?? ?? 3 ?? 1. ?? ?? ?? 2. ??? ??? ?? ?? 3. ?? ?? ??? ?? ??.

18. ? 2 ? ?????? ?? ?? 4. ?? ?? ?? 1. ?? ?? ?? ?? 2.?? ?? ?? ?? 1) ?? ?? ??? 2) ?? ?? ???

19. Chronic Lymphedema as Vascular Complication of Breast & Pelvic Surgery Current Concepts on Its Management

20. Acute and/or chronic Local and/or systemic Combined with venous system involvement Vascular Complication of Breast & Pelvic Surgery

21. Deep vein thrombosis of lower extremity Iliofemoral vein thrombosis - Phlegmasia alba dolens - Phlegmasia cerulea dolens Pulmonary embolism Venous Complication of Pelvic Surgery

22. ? 2 ? ?????? ?? ?? ?????? thrombocytopenia ? ?? ??? ?? ?? 1?? 15?~60?? ? ?? 1?? ??? ??? 10?? ??? ?? ? ?? ?? ? ??? ?..

23. ? 2 ? ?????? ?? ?? ??????, thrombocytosis ??? ?? ?? ??? ?? ??. ?? ??? ? ??? ?? ??? ???? ??? ?? ?? ?? ??? ????? ??, ?? ?, ????? ?? ?? ??? ??? ?? ??, ??? ??? ? ??.

24. What is the Platelet ?

25. Platelet Adhesion

26. Platelet Aggregation

27. ? 2 ? ?????? ?? ?? ???? ?? ?? ????? ??? ??? ?? ????? ??? ?? ?? ????? ??? ?? ??? ?? ?????? ???? ??

28. Normal Endothelium These include effects on platelets, blood coagulation, and fibrinolysis..

29. ? 2 ? ?????? ?? ?? ??? ? ???? ?? ????? ? ? ????

30. ? 2 ? ?????? ?? ?? ?? ?? ? ????? ??? ?? ??. ?? ??? ?? ? ????? ??? ??. ?????(??) ? ??? ?? ?? ??.

31. Scanning Electron micrograph of the thrombus …in the coronary artery section

32. Photomicrograph of the arterial infarction

33. Efficacy of Aspirin Inhibition of platelet activation Risk reduction of stroke

34. ? 2 ? ?????? ?? ?? ?? ?? ? TC(Total Cholesterol), TG(Triglyceride ), LDL (Low Density Lipoprotein), VLDL(Very Low Density Lipoprotein), HDL (High Density Lipoprotein) ?.. ? ??????, ???? ??? ????. ????? ? ??? ? ? ??????

35. ? 2 ? ?????? ?? ?? ????? ? ? ???, ????, ??? ??? ?? ?? ?? ???? ????? ? ???? ?? ? ?? ?? ?? ??? ??

36. ? 11? ????? ?3? ?????? ?? ??

37. ?????? ?? ??(??) ?? R&D Value Chains

38. ?? Drug Targets

39. Post - Genomics

40. Too many targets?: >5000-10,000 targets Organic chemists have a lot of things to do

41. Post Genomics Drug Discovery

42. Lead Generation

43. New Approach in Lead Generation

44. Gene Family (?)

45. Thank you for your attention !!

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