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Bacterial Infection of Cardiovascular system. By. Dr. Humodi A. Saeed Associate Prof. of Medical Microbiology College of Medical Laboratory Science Sudan University of Science and Technology E mail address: Biotechsust@hotmail.com. Cardiovascular system (CVS). Cardiovascular system (CVS).

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Bacterial Infection of Cardiovascular system

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Bacterial Infection of Cardiovascular system

By

Dr. Humodi A. Saeed

Associate Prof. of Medical Microbiology

College of Medical Laboratory Science

Sudan University of Science and Technology

E mail address: Biotechsust@hotmail.com


Cardiovascular system (CVS)


Cardiovascular system (CVS)

What is Cardiovascular system?


Cardiovascular system (CVS)

Definition

Cardiovascular system (circulatory system), defined as a group of organs that transport blood and the substances it carries to and from all parts of the body.


Bacterial Infection of CVS

Components?


Cardiovascular system (CVS)

Components

The cardiovascular (circulatory) system consists of :

1. The heart

2. Blood vessels.


Bacterial Infection of CVS

Functions?


Cardiovascular system (CVS)

Functions

1. Circulates blood throughout the body.

2. Delivers nutrients and other essential materials to cells.

3. Removes waste products.


Cardiovascular system (CVS)

Function

(It serves as the body's transportation system).


Bacterial Infection of CVS

Diseases?


Cardiovascular system (CVS)

Cardiovascular diseases

Disease of the heart and blood vessels.


Cardiovascular system (CVS)

Bacteraemia


Bacterial Infection of CVS

1. Bacteraemia

  • Presence of organisms not permanent.

  • Organisms not multiplying.

  • Patient asymptomatic.

  • Important means of spread for other diseases.


Bacterial Infection of CVS

Causes of Bacteraemia

  • Group B streptococcus

  • Escherichia coli (and other enteric Gram negative bacilli)

  • Listeria monocytogenes

  • Streptococcus pneumoniae

  • Haemophilus influenzae

  • Staphylococcus aureus

  • Neisseria meningitides

  • Salmonella spp


Bacterial Infection of CVS

Causes of Bacteraemia (cont.)

  • Streptococcus pneumoniae

  • Group B streptococcus

  • Neisseria meningitides

  • Salmonella spp

  • Haemophilus influenzae

  • Listeria monocytogenes


Bacterial Infection of CVS

Causes of Bacteraemia (cont.)

  • Streptococcus pneumoniae

  • Haemophilus influenzae

  • Neisseria meningitides

  • Salmonella spp


Cardiovascular system (CVS)

Septicaemia


Cardiovascular system (CVS)

2. Septicaemia

Septicaemia is a potentially life-threatening infection in which large amounts of multiplying bacteria are present in the blood. It is commonly referred to as blood poisoning.


Bacterial Infection of CVS

Septicaemia

  • Organisms actively multiplying.

  • Patient acutely symptomatic.


Bacterial Infection of CVS

Causes

Septicaemia usually arises as a result of localised infection in the body. The primary site of infection may occur in the:

  • Respiratory system

  • Skin

  • The gastrointestinal system

  • Genitourinary system.

    Bacteria usually spill over from the primary infection site into the blood and are carried throughout the body thereby spreading infection to various systems of the body.


Bacterial Infection of CVS

Symptoms

  • Fevers

  • Chills

  • Rash


Bacterial Infection of CVS

Mortality

  • Very high even with prompt therapy.

  • Gram positive 10 – 20%

  • Gram negatuve 25 – 40%

  • Septic shock 40 – 90%


Bacterial Infection of CVS

Endocarditis


Bacterial Infection of CVS

3. Endocarditis

Viridans Streptococci

Streptococcus pneumoniae

Staphylococcus aureus

CoN Staphylococci Stomatococcus species

Enterococcus species


Bacterial Infection of CVS

3. Endocarditis (Cont.)

HACEK group

Bartonella species

Rickettsia burnetii

Brucella species

Erysipelothrix rhusiopathiae

Enterobacteriaceae

Ps. aeruginosa,

Corynebacterium sp. Propionibacterium sp.


Bacterial Infection of CVS

Myocarditis


Bacterial Infection of CVS

4. Myocarditis

Cory.diphtheriae

Clostridium perfringens

group A Streptococcus Borrelia burgdorferi Neisseria meningitidis Staphylococcus aureus


Bacterial Infection of CVS

4. Myocarditis (Cont.)

Mycoplasma pneumoniae

Chlamydia pneumoniae

Chlamydia psittaci

Rickettsia rickettsii

Rickettsia tsutsugamushi


Bacterial Infection of CVS

Pericarditis


Bacterial Infection of CVS

5. Pericarditis

Streptococcus pneumoniae

Staphylococcus aureus

Neisseria gonorrhoeae

Neisseria meningitidis

Mycoplasma pneumoniae

Mycobacterium tuberculosis


Bacterial Infection of CVSLab. Diagnosis

Specimen

Blood


Bacterial Infection of CVSLab. Diagnosis

Essential points

  • Multiple collections

    (3 in 24 hours)

  • Maximum volume

    (do not overfill!)

    3. Aseptic collection / handling technique is CRITICAL


Bacterial Infection of CVS Lab. Diagnosis

Microscopy

Gram stain

To detect:

  • Gram positive

    2. Gram negative


Bacterial Infection of CVS Lab. Diagnosis

Blood culture:

To isolate the causative agent (s).


Bacterial Infection of CVS

Treatment

After performing sensitivity test.


Thank you


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