S easonal a ffective d isorder jb leiknes
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S easonal A ffective D isorder JB Leiknes. Seasonal Affective Disorder. Mood disorder People who are normally happy experience depressive symptoms during winter months “Winter-blues” or “winter depression” More prevalent in nordic countries

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S easonal a ffective d isorder jb leiknes

Seasonal Affective Disorder

JB Leiknes


Seasonal affective disorder

Seasonal Affective Disorder

  • Mood disorder

  • People who are normally happy experience depressive symptoms during winter months

  • “Winter-blues” or “winter depression”

  • More prevalent in nordic countries

  • First described by scholar Jordanes in the 6th century in his book Getica1

  • Most prevalent during winter months but can occur during other seasons [Reverse Seasonal Affective Disorder]


Classification of sad

Classification of SAD

  • In order to qualify as SAD a diagnosis must meet 4 criteria2:

    • Depressive periods at a particular time of year

    • Relapse into depression or mania/hypomania at a particular time of year

    • Pattern of depression lasting two or more years with no nonseasonal major depressive episodes during the same period

    • The instances of depression following a seasonal pattern must outnumber other instances of depression throughout patient's life


Etiology

Etiology

  • Believed to be light-related

    • Evidence: effectiveness of light-therapy3

  • Serotonin polymorphisms4

    • Association between SAD and the shorter allele of the serotonin transporter promoter repeat length polymorphism (5-HTTLPR)‏

  • Mutation in the gene expressing melanopsin

    • Photopigment found in retina, participates in circadian rhythm


Treatment

Treatment

  • Primarily concerning winter-based SAD

    • Light therapy

      • Bright light therapy/dawn simulation5

    • Medication

    • Timed administration of the hormone melatonin

  • Main theory behind treatment is adjustment of circadian rhythm via use of light or hormones/medicaments to mimic or induce the body's own mechanisms of circadian rhythm


Cultural impact

Cultural Impact

  • Light cafés

  • Commercially available bright-lights


Sources

Sources

1 – [Wikipedia] Jordanes' Getica – http://en.wikipedia.org/wiki/Getica_(Jordanes)‏

2 – [Mayo Clinic] Depression - Seasonal Affective Disorder (SAD) – http://www.mayoclinic.com/health/seasonal-affective-disorder/DS00195/DSECTION=symptoms

3 – [American Journal of Psychiatry] The Can-SAD Study: A Randomized Controlled Trial of the Effectiveness of Light Therapy and Fluoxetine in Patients With Winter Seasonal Affective Disorder – http://ajp.psychiatryonline.org/cgi/content/abstract/163/5/805

4 – [Neurobiology of Disease] Seasonal Affective Disorder and Serotonin-Related Polymorphisms – http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNK-457VFDV-13&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=cdf40c7c01f51290364ab7709dbeacf4

5 – [Biological Psychiatry] Dawn simulation and bright light in the treatment of SAD: a controlled study – http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4S-43RJ7CF-8&_coverDate=08%2F01%2F2001&_alid=509264218&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4982&_sort=d&view=c&_acct=C000022721&_version=1&_urlVersion=0&_userid=489256&md5=c2dc9bcba4a21f35f9482ab0fd10cd1a


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