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Peste polmonare

Peste polmonare. Prof. Pasquale Urbano. Bubbonica vs polmonare. Peste Polmonare. Incubazione: 2-3 d Sintomi Polmonite fulminante; sputo ematico; shock settico; febbre alta; brividi; cefalea; possibile coagulazione intravascolare disseminata Diagnosi

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Peste polmonare

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  1. Peste polmonare Prof. Pasquale Urbano

  2. Bubbonica vs polmonare

  3. Peste Polmonare • Incubazione: 2-3 d • Sintomi • Polmonite fulminante; sputo ematico; shock settico; febbre alta; brividi; cefalea; possibile coagulazione intravascolare disseminata • Diagnosi • Laboratorio: Batterioscopia (Gram) su sangue, escreato, bubboni • Piccoli coccobacilli Gram negativi, poco colorati, bipolari (a spillo da balia)

  4. Peste polmonare • Isolamento! • Fortementecontagiosa • Isolamentorespiratoriostretto, fino a 3 ggdopo la terapia • In seguito, precauzioni standard contro le gocciolinerespiratorie (maschere, camici, guanti, paraocchi) • Trattamento • Streptomicina, doxiciclina, o cloramfenicolo • Alta letalità, ma buonarisposta a trattamentoprecoce

  5. IF diretta

  6. Peste setticemica

  7. Definizioni epidemiologiche • Possible case • Sudden onset of severe, unexplained febrile respiratory illness • Unexplained death following a short febrile illness • Sepsis with Gram-negative coccobacilli identified from clinical specimens • Probable case • A case that clinically fits the criteria for suspected plague, and in addition, positive results are obtained on one or more specimens • Definitive diagnosis • A clinically compatible case with confirmatory laboratory results • Culture of Y. pestis from a clinical specimen and confirmation of identification by phage lysis • A significant (4-fold) change in antibody titre to F1 antigen in paired serum samples • A presumptive diagnosis, by positive PCR or detection of F1 antigen on suspect isolates, will be available within one working day

  8. Il contatto stretto, per la trasmissione aerogena tramite le goccioline di Pflugge Indossare la maschera!

  9. PLAGUE, PNEUMONIC - CONGO DR (ITURI).************************************.A ProMED-mail post.<http://www.promedmail.org>.Source: WHO Outbreak Reports 18 Feb 2005 • Allarme per un’epidemia di peste polmonare nel Congo • Leggere le note, col dispaccio

  10. Febbraio 2011 - PLAGUE, PNEUMONIC - MADAGASCAR • An epidemicofpneumonicplaguehasbeenragingforweeks in the northernregionof Madagascar, mainlyaroundAmbilobe. • There are already 16 deathsattributedtothisepidemic.

  11. Y. pestis come arma • Sperimentata sul campo dai Giapponesi • Diffusione di ratti e pulci infette • Sviluppata su scala industriale dall’URSS • Per diffusione tramite aerosol • Sviluppata da Irak, Sud Africa, … • Rientra fra gli agenti di Categoria A

  12. Approfondimenti • Linee guida cliniche • Consensus • Textbook of Military Medicine, Ch. 23

  13. Grazie dell’attenzione Domande? Torna a Peste.ppt

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