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JEOPARDY. IMMUNOLOGY. WEILL CORNELL MEDICAL COLLEGE - QATAR. This costimulator is expressed by professional APCs including B cells, dendritic cells, and macrophages and binds to molecules on T cells called CD28. What is B7 OR B7.1 or B7.2?. WEILL CORNELL MEDICAL COLLEGE - QATAR.

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Jeopardy l.jpg

JEOPARDY

IMMUNOLOGY

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is b7 or b7 1 or b7 2 l.jpg

This costimulator is expressed by professional APCs including B cells,dendritic cells, and macrophages and binds to molecules on T cells calledCD28.

What is B7 OR B7.1 or B7.2?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


These cells regulate the infiltration of leukocytes into inflammatory reactions l.jpg

These cells regulate the infiltration of leukocytes into inflammatoryreactions.

What are venular endothelial cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide4 l.jpg

This complement component can mimic immediate hypersensitivity reactions bydirectly causing mast cell degranulation.

What is C5a?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This immunosuppressive drug inhibits transcription of the il 2 gene l.jpg

This immunosuppressive drug inhibits transcription of the IL-2 gene.

What is cyclosporin A?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide6 l.jpg

To avoid hypeacute rejection of grafts, efforts must be made to ensure thatdonor and recipient match with respect to these antigens.

What are the ABO blood group antigens?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide7 l.jpg

This rare renal complication is caused by human immune complex disease andfollows infection with a gram-positive organism.

What is post -streptococcal glomerulonephritis?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Affinity maturation in b cells mainly occurs in these lymphoid structures l.jpg

Affinity maturation in B cells mainly occurs in these lymphoid structures.

What are germinal centers?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The migration of lymphocytes into secondary lymphoid organs occurs through these l.jpg

The migration of lymphocytes into secondary lymphoid organs occurs throughthese.

What are high endothelial venules OR What are HEV?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is bcl 2 l.jpg

Centrocytes binding antigen and either complement or CD23 on foliculardendritic cells are induced to express this surface determinant to ensuretheir survival.

What is BCL-2?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide11 l.jpg

The distribution of variable residues in immunoglobulin that yieldsvariability can be measured using this famous plotting method.

What is Wu and Kabot?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This type of immunity is present at birth and does not exhibit specificity for a foreign antigen l.jpg

This type of immunity is present at birth and does not exhibit specificityfor a foreign antigen.

What is innate immunity ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What are haptens l.jpg

These low molecular weight compounds are not immunogenic by themselves butcan become immunogenic if they are coupled to a higher molecular weightcompound.

What are haptens?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide14 l.jpg

A secondary, anamnestic immune response occurs more rapidly than a primaryimmune response because of the presence of these cells.

What are memory cells ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This process refers to the coating of antigen by antibody or complement to facilitate phagocytosis l.jpg

This process refers to the coating of antigen by antibody or complement tofacilitate phagocytosis.

What is opsonization?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The classical and alternate pathways of complement converge on which component of complement l.jpg

The classical and alternate pathways of complement converge on whichcomponent of complement.

What is C3?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This immunodeficiency is associated with the failure of b cells to mature l.jpg

This immunodeficiency is associated with the failure of B cells to mature.

What is Bruton's agammaglobulinemia or X-linked agammaglobulinemia?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This molecule consist of an a chain non covalently associated to b2 microglobulin l.jpg

This molecule consist of an a chain non covalently associated to B2microglobulin.

What is Class I MHC(major histocompatibility complex)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


These cells are said to be restricted by mhc class i molecules l.jpg

These cells are said to be restricted by MHC class I molecules.

What are CD8 T cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


These are the major cytokines produced by cd4 th2 cells l.jpg

These are the major cytokines produced by CD4 TH2 cells.

What are IL-4, IL-5, IL-10 and IL-13 (Interleukin 4, 5,10, and 13)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What are t cells l.jpg

A 9 month old baby was vaccinated against smallpox with attenuated smallpox virus. He developed a progressive necrotic lesion of the skin, muscles, and subcutaneous tissue at the site of inoculation. A deficiency of thesecells might account for this reaction.

What are T cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This type of hypersensitivity can lead to the development of granulomas l.jpg

This type of hypersensitivity can lead to the development of granulomas.

What is delayed type hypersensitivity (or hypersensitivity type IV)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide23 l.jpg

This disease is characterized by IgM antibodies present in synovial fluidswhich have specificity for the heavy chain of IgG antibodies.

What is Rhematoid Arthritis?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The following may result when a t cell recognizes an antigen in the absence of co stimulation l.jpg

The following may result when a T cell recognizes an antigen in the absenceof co-stimulation.

What is T cell anergy ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This is the site of somatic mutation and immunoglobulin heavy chain class switching l.jpg

This is the site of somatic mutation and immunoglobulin heavy chain classswitching.

What is the germinal center ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Receptors for the c1 component of complement are found on these two classes of immunoglobulin l.jpg

Receptors for the C1 component of complement are found on these two classesof immunoglobulin.

What are IgM and IgG?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This is the predominant isotype of an antibody produced in a primary immunization l.jpg

This is the predominant isotype of an antibody produced in a primaryimmunization.

What is IgM ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide28 l.jpg

Alternative RNA splicing enables a B cell to co-express these twoantibodies on a B cell simultaneously.

What are IgM and IgD?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This assay measures the clumping together of an antibody with a particulate antigen l.jpg

This assay measures the clumping together of an antibody with a particulateantigen.

What is an agglutination reaction?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide30 l.jpg

A solid phase immunoassay which is commonly used in clinical laboratoriesto detect the presence of antibodies to gp120 in a serum sample.

What is an ELISA?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide31 l.jpg

These molecules generally present exogenously derived peptides frombacterial antigens to CD4 T cells.

What are Class II MHC (major histocompatibility ) molecules?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This autoimmune disease is mediated by antibodies to acetylcholine receptors l.jpg

This autoimmune disease is mediated by antibodies to acetylcholine receptors.

What is Myasthenia Gravis?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide33 l.jpg

This reaction commonly occurs when bone marrow cells are transplanted into an immunocompromised host.

What is a graft-versus-host (GVH) reaction?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What are b cells l.jpg

A 7 month old baby has a history of repeated ear infections and bacterialinfections, and has been hospitalized with pneumonia twice. The babylikely has a deficiency of these cells.

What are B cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


These molecules are co dominantly expressed on cells l.jpg

These molecules are co-dominantly expressed on cells.

What are MHC (major histocompatibility) molecules?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The process whereby t cells learn to respond to antigen in the context of self mhc l.jpg

The process whereby T cells learn to respond to antigen in the context ofself MHC?

What is MHC restriction?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide37 l.jpg

This substance enhances the immune response to an antigen but does notconfer immunogenicity to a hapten.

What is an adjuvant?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide38 l.jpg

These antigens bind outside the peptide binding groove on MHC class IImolecules and activate a family of T cells.

What are superantigens?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


A state of non responsiveness to antigen l.jpg

A state of non responsiveness to antigen.

What is anergy?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The site of t cell education l.jpg

The site of T cell education.

What is the thymus?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is the arthus reaction l.jpg

This type of hypersensitivity reaction is produced by the local formationof antigen-antibody aggregates which activate the complement cascade andcause acute intradermal inflammation.

What is the Arthus reaction?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This drug inhibits mast cell degranulation l.jpg

This drug inhibits mast cell degranulation.

What is sodium cromoglycate?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide43 l.jpg

This cytokine is the principal mediator of the response to gram negativebacteria. Its major cell source is the activated phagocyte.

What is TNF?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is ifn g l.jpg

This TH1 cytokine is a potent activator of macrophages and upregulates theexpression of Class I and Class II MHC molecules on a variety of celltypes.

What is IFN-g ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide45 l.jpg

This motif which is found in the cytoplasmic domains of CD3 proteins and inIga and IgB has important signaling functions.

What is the immunoreceptor tyrosine based activation motifs (ITAM)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide46 l.jpg

This immunosuppressive drug acts by specifically interfering with theprotein kinases involved in IL-2/IL-2 receptor signaling.

What is Rapamycin ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Hemolytic disease of the newborn is induced by transfer of maternal antibodies of this isotype l.jpg

Hemolytic disease of the newborn is induced by transfer of maternalantibodies of this isotype.

What are IgGs?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide48 l.jpg

This refers to the increase in the affinity of antibodies produced duringthe course of a humoral immune response.

What is affinity maturation ?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Cytotoxic t cell lysis of target cells is mediated by the release of these substances from granules l.jpg

Cytotoxic T cell lysis of target cells is mediated by the release of thesesubstances from granules.

What are perforin and granzyme B?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The process whereby natural killer cells can lyse antibody coated target cells l.jpg

The process whereby Natural Killer cells can lyse antibody coated target cells.

What is antibody dependent cell cytotoxicity (ADCC)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The phenomenon whereby a b cell produces an antibody of a single specificity only l.jpg

The phenomenon whereby a B cell produces an antibody of a singlespecificity only.

What is allelic exclusion?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This disease arises as a consequence of a deficiency of c1 inhibitor c1inh l.jpg

This disease arises as a consequence of a deficiency of C1 inhibitor (C1INH).

What is Hereditary angioneurotic edema?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide53 l.jpg

This is the process in which thymocytes whose TCRs bind with high avidityto self MHC complexed with antigen are eliminated.

What is negative selection (or apoptosis)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide54 l.jpg

The ribbon like deposit of antibody along kidney basement membranesis is characteristic of this disease.

What is Goodpasture's syndrome?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This receptor ligand pair can mediate activation induced cell death in t and b cells l.jpg

This receptor/ligand pair can mediate activation induced cell death inT and B cells.

What is Fas/FasL (ligand)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide56 l.jpg

The interaction of this receptor/ligand pair is involved in immunoglobulinheavy chain class switching.

What is CD40/CD40L (ligand)?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide57 l.jpg

These cells constitute less than 5% of the peripheral T cell population andthey appear in the thymus before aB expressing T cells appear.

What are gd (gamma-delta) T cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This zeta associated tyrosine kinase is involved in t cell signaling l.jpg

This zeta associated tyrosine kinase is involved in T cell signaling.

What is Zap-70?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is anaphylactic shock l.jpg

While eating peanut butter cookies, an 8 year old boy began vomiting, haddifficulty in breathing and developed a swollen face. He was immediatelyrushed to the hospital and was unconscious upon arrival. His bloodpressure was dangerously low. The most likely diagnosis of the child'ssymptoms is?

What is anaphylactic shock?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide60 l.jpg

What should the child immediately be injected with in order to raise hisblood pressure and facilitate his breathing?

What is epinephrine?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide61 l.jpg

The symptoms that this child was experiencing were precipitated by therelease of granules from this cell type.

What are mast cells and/or basophils?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is cd45 l.jpg

This membrane molecule has a cytoplasmic tail with two protein tyrosine phosphatase domains, which are thought to catalyze dephosphorylation of a tyrosine residue of p56lck and p59fyn.

What is CD45?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


About 90 99 of the peripheral t cells express this type of t cell receptor l.jpg

About 90-99% of the peripheral T cells express this type of T cell receptor.

What is abTCR?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Macrophages in the kidney are called by this name l.jpg

Macrophages in the kidney are called by this name.

What are Kupffer cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This substance nonspecifically enhances or potentiates the immune response to an antigen l.jpg

This substance nonspecifically enhances or potentiates the immune response to an antigen.

What is an adjuvant?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide66 l.jpg

This is the invarient subunit that is associated with the polymorphic a chain to form class I MHC molecule.

What is b2-microglobulin?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The phosphatase calcineurin dephosphorylates a cytoplasmic component of this transcription factor l.jpg

The phosphatase calcineurin dephosphorylates a cytoplasmic component of this transcription factor.

What is NFATc?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This molecule is expressed by both resting and activated t cells and binds with b molecule on apc l.jpg

This molecule is expressed by both resting and activated T cells and binds with B moleculeon APC.

What is CD28?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide69 l.jpg

In this specific process, Natural Killer (NK) cells bind to antitumor antibodies bound to the surface of the tumor cells and lyse them.

What is Antibody-Dependent Cell-mediated Cytotoxicity, ADCC?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is plc g1 l.jpg

Phosphorylation of this allows it to hydrolyze phosphatidylinositol 4, 5- bisphosphate ( PIP2) into IP3 (inositol 1,4,5-triphosphate) and DAG (diacylglycerol)

What is PLC-g1?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide71 l.jpg

This reaction develops when a graft contains immunocompetent T cells that recognize and attack the reciepient=s cells.

What is graft versus host disease?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What are called high endothelial venules l.jpg

Regions of vascular endothelium found in postcapillary venules of various lymphoid organs that are composed of specialized cells with plump cuboidal shape.

What are called high endothelial venules?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What are chemokines l.jpg

These small peptides attract different types of leukocytes and regulate the expression and conformation of adhesion molecules on leukocyte membranes.

What are chemokines?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Mip 1a and mip 1b belong to this subgroup of chemokines l.jpg

MIP-1a and MIP-1b belong to this subgroup of chemokines.

What is C-C subgroup of chemokines?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Il 8 belongs to this subgroup of chemokines l.jpg

IL-8 belongs to this subgroup of chemokines.

What is C-X-C subgroup?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is erythroblastosis fetalis l.jpg

This is Type II hypersensitive reaction in which maternal antibodies against fetal Rh antigens cause hemolysis of the erythrocytes of a newborn.

What is Erythroblastosis fetalis?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Of the dna binding proteins only this is t cell specific l.jpg

Of the DNA binding proteins, only this is T cell specific.

What is NFAT?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide78 l.jpg

Diacylglycerol (DAG) activates protein kinase C (PKC) which mediates the release of this transcription factor.

What is NF-kB?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide79 l.jpg

Naive T cells and memory T cells are distinguished by these surface molecules using immunofluorescence.

What are CD45RA and CD45RO respectively?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This t helper subset functions more effectively as a helper for b cell activation l.jpg

This T helper subset functions more effectively as a helper for B cell activation.

What is Th2 subset?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is il 12 l.jpg

This cytokine is secreted by activated macrophages in response to bacterial or protozoan infections, which induces proliferation of NK cells and Th1 cells resulting in incresed IFN-g production.

What is IL-12?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide82 l.jpg

Inositol Triphosphate (IP3) triggers an increase in intracellular Ca2+ and subsequent activation of this calmodulin-dependent phosphatase.

What is calcineurin?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide83 l.jpg

The transient increase in the number of circulating neutrophils to indicate the presence of an infection is medically denoted by this name.

What is Leukocytosis?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is invariant chain l.jpg

In the endocytotic pathway, within the endoplasmic reticulum (RER), class II MHC molecules are associated with this, which blocks binding of peptide.

What is Invariant Chain?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide85 l.jpg

Bacterial septic shock develops when bacterial cell wall endotoxins stimulate macrophages to overproduce these inflammatory cytokines.

What are IL-1 and TNF-a?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This is a potent proteolytic enzyme that breaks down fibrin clots in to degradation products l.jpg

This is a potent proteolytic enzyme that breaks down fibrin clots in to degradation products.

What is plasmin?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide87 l.jpg

These strands criss-cross one another to form a clot which serves as barrier to the spread of infection.

What are fibrin strands?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is bradykinin l.jpg

This end product of the kinin system is a potent vasoactive basic peptide that increases vascular permeability, causes vasodilation, induces pain, and induces contraction of smooth muscle.

What is bradykinin?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Prostaglandins are produced by the metabolism of this via the cyclooxygenase pathway l.jpg

Prostaglandins are produced by the metabolism of this via the cyclooxygenase pathway.

What is Arachidonic acid?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This is an immunosuppressive drug commonly used to prevent graft rejection l.jpg

This is an immunosuppressive drug commonly used to prevent graft rejection.

What is cyclosporin A?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide91 l.jpg

This T helper subset is responsible for classical cell mediated functions such as delayed type hypersensitivity.

What is Th1 subset?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide92 l.jpg

The initial activation of both T cells and B cells is thought to take place in this region of the lymphonode.

What is paracortex?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide93 l.jpg

This cytokine is produced by TH1 cells and can induce macrophages to increase MHC class II expression.

What is IFN gamma?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Absence of this receptor in t cells is associated with hyper igm syndrome l.jpg

Absence of this receptor in T cells is associated with hyper IgM syndrome.

What is CD40L?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


These cells reside in the skin and are major antigen presenting cells l.jpg

These cells reside in the skin and are major antigen-presenting cells.

What are Langerhans cells?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


These drugs block h1 and h2 receptors on target cells and is used to treat atopy l.jpg

These drugs block H1 and H2 receptors on target cells and is used to treat atopy.

What are antihistamines?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide97 l.jpg

Also called multi-colony-stimulating factor, this cytokine stimulates growth of precursors of most bone marrow-derived cells.

What is IL-3?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide98 l.jpg

Defects in enzymes involved in nucleotide degradation lead to this SCID which leads to accumulation of nucleotide metabolites.

What is adenosine deaminase

deficiency? OR What is purine nucleotide phosphorylase deficiency?

OR What is ADA deficiency?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Folding of this region of the ig molecule produces a cleft in which binding of antigen occurs l.jpg

Folding of this region of the Ig molecule produces a cleft in which binding of antigen occurs.

What is the hypervariable region?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide100 l.jpg

Digestion of anti-sheep red blood cell (SRBC) antibodies with this enzyme will result in a reagent which will still agglutinate SRBC.

What is pepsin?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide101 l.jpg

This joining rule assures proper VL-JL or VH-DH-JH joining during rearrangement of immunoglobulin genes.

What is the 12/23 joining rule?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


The antigen independent phase of b cell differentiation occurs here l.jpg

The antigen-independent phase of B cell differentiation occurs here.

What is the bone marrow?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


What is the invariant chain l.jpg

The presence of this chain within the endoplasmic reticulum is thought to prevent peptide binding to class II MHC molecules during antigen processing.

What is the invariant chain?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide104 l.jpg

Upon activation of T cells, expression of this ensures that only activated cells will undergo proliferative responses to antigen.

What is IL-2R? OR What is Interleukin-2-receptor? OR What is IL-2 receptor?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Eskimos get these when sitting on the ice too long l.jpg

Eskimos get these when sitting on the ice too long.

What are Polaroids?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Molecular mimicry is one mechanism proposed to account for the development of this l.jpg

Molecular mimicry is one mechanism proposed to account for the development of this.

What is autoimmunity?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide107 l.jpg

Phagocytic activity of macrophages and neutrophils is promoted by interferon gamma and this other cytokine.

What is tumor necrosis factor alpha OR what is TNF alpha OR what is TNFa?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide108 l.jpg

Immunity to bacterial infections is usually mediated by these unless the organism is capable of intracellular growth.

What are antibodies?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


This form of scid is caused by a deficiency in class i or class ii mhc expression l.jpg

This form of SCID is caused by a deficiency in class I or class II MHC expression.

What is Bare lymphocyte syndrome?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Slide110 l.jpg

This is the process by which rearranged genes for heavy and light chains from only one chromosome are expressed.

What is allelic exclusion?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


Lymphocytes migrate from the blood to lymphoid organs through these l.jpg

Lymphocytes migrate from the blood to lymphoid organs through these.

What are HEV OR What are high endothelial venules?

WEILL CORNELL

MEDICAL COLLEGE - QATAR


T h e l.jpg

THE

END

WEILL CORNELL

MEDICAL COLLEGE - QATAR


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