`. Prevalence of Low T3 syndrome and its association with severity in patients of Chronic heart failure : A hospital based study Sangeet Saurav , Abhinaba Debnath ,Anupam Singh, Rajendra Jha Department of Medicine , RIMS,Ranchi. Introduction.
Prevalence of Low T3 syndrome and its association with severity in patients of Chronic heart failure : A hospital based study
SangeetSaurav, AbhinabaDebnath,Anupam Singh, RajendraJha
Department of Medicine ,
in patients with acute myocardial infarction and heart
. The principal pathophysiological mechanism underlying low circulating T3 is the reduced enzyme activity of monodeiodinase responsible for converting T4 into T3 inperipheral tissues
This low-T3 syndrome has commonly been interpreted by
the medical community as an euthyroid sick syndrome, an
adaptive compensatory and thus beneficial response that
decreases energy consumption
However new Western studies suggest that Low-T3 syndrome is a strong predictor of death in cardiac patients and might be directly implicated in the poor prognosis of cardiac patients.
This is the first hospital based study to determine prevalence of low T3 syndrome in CHF in India,which is quite high.
Higher prevalence of low T3 syndrome is seen in patients of severe NYHA classes. In these patients,f T3 levels also came out to be positively correlated with LVEF and significantly negatively correlated with LA size and LVEDD.
Further studies must be done in future to consider a trial of low dose thyroxine in patients of CHF with low T3 syndrome